| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T c…
PMID: 26209553
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
OBJECTIVE: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo h…
Control of intestinal homeostasis through crosstalk between natural killer T ce…
PMID: 25988859
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
The human host and the intestinal microbiota co-exist in a mutually beneficial relationship, which contributes to host and microbial metabolism as we…
Keeping bugs in check: The mucus layer as a critical component in maintaining i…
PMID: 25914114
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
In the mammalian gastrointestinal tract the close vicinity of abundant immune effector cells and trillions of commensal microbes requires sophisticat…
The multifaceted role of commensal microbiota in homeostasis and gastrointestin…
PMID: 25759839
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
The gastrointestinal tract houses a complex and diverse community of microbes. In recent years, an increased understanding of the importance of intes…
Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
PMID: 25345825
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities rangi…
Breast milk, microbiota, and intestinal immune homeostasis
PMID: 25310762
Year: 2015
Relationship Type:
Correlation Studies
Score: 5.3
Newborns adjust to the extrauterine environment by developing intestinal immune homeostasis. Appropriate initial bacterial colonization is necessary …
Interplay of nutrients and microbial metabolites in intestinal immune homeostas…
PMID: 25227295
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
The intestinal mucosa is the largest body surface exposed to the environment. While there are common features when comparing immune responses along t…
Anatomical localization of commensal bacteria in immune cell homeostasis and di…
PMID: 24942680
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
The mammalian gastrointestinal (GI) tract is colonized by trillions of beneficial commensal bacteria that are essential for promoting normal intestin…
Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosa…
PMID: 24637794
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Heme oxygenase-1 (HO-1) and its enzymatic by-product carbon monoxide (CO) have emerged as important regulators of acute and chronic inflammation. Mec…
Leukocyte-epithelial interactions and mucosal homeostasis
PMID: 24285670
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Many common inflammatory disorders are characterized by the infiltration of neutrophils across epithelial lined (mucosal) surfaces resulting in disru…
Role of the enteric microbiota in intestinal homeostasis and inflammation
PMID: 24275541
Year: 2014
Relationship Type:
Clinical Research
Score: 5.3
Novel carrier-linked azo prodrugs of 4 and 5-aminosalicylic acids (4-ASA and 5-ASA respectively) using the same drugs as carriers in different permu…
EBV-associated colonic B-cell lymphoma following treatment with infliximab for …
PMID: 24081592
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
IL-15 is a member of the IL-2 family of cytokines whose signaling pathways are a bridge between innate and adaptive immune response. IL-15 is part o…
Dietary inhibitors of histone deacetylases in intestinal immunity and homeostas…
PMID: 23914191
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal epithelial cells (IECs) are integral players in homeostasis of immunity and host defense in the gut and are under influence of the intesti…
Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasi…
PMID: 23760057
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fi…
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe hom…
PMID: 23663779
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
All metazoan guts are subjected to immunologically unique conditions in which an efficient antimicrobial system operates to eliminate pathogens while…
Macrophage biology in development, homeostasis and disease.
PMID: 23619691
Year: Unknown
Relationship Type:
Therapeutic Applications
Score: 5.3
Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in de…
T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis fac…
PMID: 23032984
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
The mammalian intestinal tract is heavily colonized with a dense, complex, and diversified microbial populations. In healthy individuals, an array o…
Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 a…
PMID: 22318539
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
Apoptosis has an essential role in controlling T cell homeostasis, especially during the contraction phase of an immune response. However, its contri…
Mucosal macrophages in intestinal homeostasis and inflammation
PMID: 22025201
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal macrophages are essential for local homeostasis and in keeping a balance between commensal microbiota and the host. However, they also pla…
Intestinal homeostasis and its breakdown in inflammatory bowel disease
PMID: 21677746
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulato…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||