| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Pediatric "PSC-IBD": a descriptive report of associated inflammatory bowel dise…
PMID: 11593125
Year: 2001
Relationship Type:
Therapeutic Applications
Score: 5.3
At the present there are no large-scale epidemiologic data on inflammatory bowel disease (IBD) in the Asia-Pacific region, but several studies have …
Interferon-gamma and interleukin-10 reciprocally regulate endothelial junction …
PMID: 11162203
Year: 2001
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Inflammatory bowel diseases (IBD) are characterised by an intense infiltration of leucocytes that is mediated by adhesion molecules expr…
Therapeutic effects of LK 423, a phthalimido-desmuramyl-dipeptide compound, on …
PMID: 10083986
Year: 1999
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: The sphingolipid sphingomyelin is a constituent in food derived from animals. Digestive breakdown of sphingomyelin results in ceramide, …
Circulating soluble factor-inhibiting natural killer (NK) activity of fresh per…
PMID: 9933422
Year: 1999
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) encompasses several chronic inflammatory disorders leading to the damage of the gastrointestinal tract. The 2 princ…
CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis ro…
PMID: 9649183
Year: 1998
Relationship Type:
Correlation Studies
Score: 5.3
Contractile responses evoked by the 5-HT IB/D receptor agonists, dihydroergotamine, naratriptan and sumatriptan, were compared in canine isolated c…
Increase of circulating gamma/delta T lymphocytes in the peripheral blood of pa…
PMID: 7923890
Year: 1994
Relationship Type:
Mechanism Investigation
Score: 5.3
Curcumin (diferulolylmethane) is an anti-inflammatory phenolic compound found effective in preclinical models of inflammatory bowel diseases (IBD) a…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review
PMID: 39907869
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), remains challenging to manage, with a substantial pr…
Delivery of Transcriptional Factors for Activating Antioxidant Defenses against…
PMID: 36881502
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.0
Oxidative stress caused by the overproduction of reactive oxygen species (ROS) plays an important role in inflammatory bowel disease (IBD). It is wel…
Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metallop…
PMID: 33946534
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
With glucose being the preferred source of energy in activated T cells, targeting glycolysis has become an attractive therapeutic intervention point…
miR-26a attenuates colitis and colitis-associated cancer by targeting the multi…
PMID: 33815939
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Patients with inflammatory bowel disease are at increased risk for colitis-associated colorectal cancer (CAC). Therefore, controlling intestinal infl…
Clinical and Mutation Description of the First Iranian Cohort of Infantile Infl…
PMID: 32633164
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammation is a hallmark in many forms of cancer; with colitis-associated colorectal cancer (CAC) being a progressive intestinal inflammation due …
Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and D…
PMID: 31726729
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.0
Macrophages drive the pathological process of inflammatory bowel diseases (IBD) mostly by secreting proinflammatory cytokines, such as Tnf-α. Recent…
Italian cohort of patients affected by inflammatory bowel disease is characteri…
PMID: 30830399
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND & AIMS: Psychological stress, in early life or adulthood, is a significant risk factor for inflammatory disorders, including inflammatory…
Relationship of clinical symptoms with biomarkers of inflammation in pediatric …
PMID: 27573259
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND: Angiogenesis plays a major role in the pathogenesis of inflammatory bowel disease (IBD). Placental growth factor (PlGF) is a specific re…
Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric…
PMID: 20890221
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.0
The complex pathogenesis of inflammatory bowel disease (IBD) and inflammation induced colon cancer involves a wide range of mediators including cyto…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||