| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Activation of signal transducer and activator of transcription-1 (STAT-1) and d…
PMID: 20345984
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.3
Pouchitis after total rectocolectomy is the most common complication of ulcerative colitis (UC). The immunological mechanisms involved in the genesis…
STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
PMID: 20200543
Year: 2010
Relationship Type:
Therapeutic Applications
Score: 5.3
The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of…
Long-lived colitogenic CD4+ memory T cells residing outside the intestine parti…
PMID: 19786550
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.3
Probiotics have been used to treat human gastrointestinal inflammations including inflammatory bowel disease (IBD). However, the exact mechanisms by…
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytok…
PMID: 19648266
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract. Although the etiology and pathogenesis of IBD remain unknown, …
Clinical study of the relationship between inflammatory bowel diseases and colo…
PMID: 19426393
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.3
Current Western therapies for inflammatory diseases are suboptimal; increasingly, patients are turning to complementary and alternative medicine for…
An antibody to IP-10 is a potent antagonist of cell migration in vitro and in v…
PMID: 19301198
Year: 2009
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Triptolide, the principal active ingredient in the extract of Chinese herb Tripterygium wilfordii Hook , has both anti-inflammatory and …
Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: …
PMID: 19197385
Year: 2009
Relationship Type:
Clinical Research
Score: 5.3
Comment in Gut. 2009 Mar;58(3):323-4. BACKGROUND: Crohn's disease and ulcerative colitis have a complex genetic background. We assessed the ris…
Quantitative gene expression of cytokines in peripheral blood leukocytes stimul…
PMID: 17900510
Year: 2007
Relationship Type:
Therapeutic Applications
Score: 5.3
Lymphocyte homing is mediated by a cascade of adhesive interactions between circulating lymphocytes and specialized endothelial cells comprising hig…
Nutrigenomics applied to an animal model of Inflammatory Bowel Diseases: transc…
PMID: 17574631
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 5.3
Excessive apoptosis induced by enteric microbes leads to epithelial barrier defects. This mechanism has been implicated in the pathogenesis of infla…
Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestin…
PMID: 17466962
Year: 2007
Relationship Type:
Therapeutic Applications
Score: 5.3
The risk for gallstones (GD) in inflammatory bowel diseases and the factors responsible for this complication have not been well established. We stu…
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipo…
PMID: 17255219
Year: 2007
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Crohn's exacerbation and pouchitis are commonly treated with ciprofloxacin and metronidazole. Few studies have shown an advantage of thi…
Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels …
PMID: 17206711
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 5.3
Mice lacking interleukin-7 (IL-7-/- mice) have no signs of autoimmune disease, contrary to other models of lymphopenia. We investigated whether the …
Dissection of the inflammatory bowel disease transcriptome using genome-wide cD…
PMID: 16107186
Year: 2005
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal inflammation is accompanied by excessive production of reactive oxygen and nitrogen metabolites. In order to counteract their harmful eff…
Diarrhea in liver transplant recipients: etiology and management
PMID: 16035068
Year: 2005
Relationship Type:
Mechanism Investigation
Score: 5.3
The pathogenic mechanism and effective treatment of inflammatory bowel disease (IBD) are still unknown. In the present study, we examined the protec…
5-Lipoxygenase modulates colitis through the regulation of adhesion molecule ex…
PMID: 15821759
Year: 2005
Relationship Type:
Mechanism Investigation
Score: 5.3
P-glycoproteins (Pgps) are adenosine triphosphate-binding transporter proteins thought to be associated with multi-drug resistance in mammals and pr…
Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport …
PMID: 15623827
Year: 2005
Relationship Type:
Therapeutic Applications
Score: 5.3
Although the cause of Crohn's disease remains unknown considerable progress has been made in recent years to unravel the pathogenesis of the inflamm…
MDR1 mRNA expressions in peripheral blood mononuclear cells of patients with ul…
PMID: 15102868
Year: 2004
Relationship Type:
Therapeutic Applications
Score: 5.3
The physiologic role of the mu opioid receptor (MOR) in gut nociception, motility, and secretion is well established. To evaluate whether MOR may al…
Interleukin-6 changes tight junction permeability and intracellular phospholipi…
PMID: 12732938
Year: 2003
Relationship Type:
Therapeutic Applications
Score: 5.3
The pathophysiology of inflammatory bowel disease (IBD) involves the production of diverse lipid mediators, namely eicosanoids, lysophospholipids, a…
Manipulation of the bacterial flora in inflammatory bowel disease
PMID: 12617882
Year: 2003
Relationship Type:
Target Validation
Score: 5.3
Inflammatory bowel diseases (IBDs) are chronic debilitating conditions, which impair the patient's quality of life significantly. Among them, Crohn'…
Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccha…
PMID: 12126249
Year: 2002
Relationship Type:
Mechanism Investigation
Score: 5.3
We report a unique case of Turner syndrome associated with acquired von Willebrand disease (AvWD), primary biliary cirrhosis (PBC), and inflammatory…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||