| Target ID: | Tar59 |
|---|---|
| ID: | P22301 |
| Target Name: | Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/P22301 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Exome sequencing identifies novel compound heterozygous mutations of IL-10 rece…
PMID: 22476154
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease is well recognized for a strong genetic involvement in its pathogenesis. Homozygous mutations in interleukin-10 receptor 1…
Targeted delivery of Grem1 and IL-10 separately by mesenchymal stem cells effec…
PMID: 39990215
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Rationale: Inflammatory bowel disease (IBD) is a relapsing and idiopathic disorder. The low therapeutic efficacy of IBD urgently prompts us to seek n…
Phenotype-Led Identification of IL-10 Upregulators in Human CD4(+) T-cells and …
PMID: 39780505
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
Therapeutics promoting the endogenous production of IL-10 have the potential to restore homeostasis in inflammatory disorders such as inflammatory bo…
Transcriptional Responses of Lacticaseibacillus rhamnosus to TNFα, IL-6, IL-8, …
PMID: 39596886
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The interaction between gut microbiota and the host immune system is a complex and understudied field, with cytokines like TNFalpha, IL-6, IL-8, and …
Propionate-producing engineered probiotics ameliorated murine ulcerative coliti…
PMID: 39553425
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic and unspecific inflammatory disorder of the gastrointestinal tract, and current treatment options often…
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerb…
PMID: 39248363
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Amlexanox (ALX) is a small-molecule drug for the treatment of inflammatory, autoimmune, metabolic, and tumor diseases. At present, there are no studi…
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis…
PMID: 37451490
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is an idiopathic intestinal disease characterized by chronic inflammation with unknown etiolo…
IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors …
PMID: 37373041
Year: 2023
Relationship Type:
Correlation Studies
Score: 5.3
Mast cells (MCs) are involved in several immune-related responses, including those in bacterial infections, autoimmune diseases, inflammatory bowel d…
Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowe…
PMID: 37209953
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic inflammatory condition that can cause severe damage to the gastrointestinal tract leading to lower qual…
IL-10 in Mast Cell-Mediated Immune Responses: Anti-Inflammatory and Proinflamma…
PMID: 34067047
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Mast cells (MCs) play critical roles in Th2 immune responses, including the defense against parasitic infections and the initiation of type I allergi…
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived in…
PMID: 33595362
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal barrier dysfunction is a pathogenic hallmark in Crohn's disease (CD). Identifying key players that regulate intestinal barrier may provide…
A Novel Fusion of IL-10 Engineered to Traffic across Intestinal Epithelium to T…
PMID: 33148717
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
IL-10 is a potent anti-inflammatory cytokine capable of suppressing a number of proinflammatory signals associated with intestinal inflammatory disea…
Systemic Molecular Mediators of Inflammation Differentiate Between Crohn's Dise…
PMID: 31241755
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Faecal diversion is associated with improvements in Crohn's disease but not ulcerative colitis, indicating that differing mechan…
Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Thr…
PMID: 30787928
Year: 2019
Relationship Type:
Target Validation
Score: 5.3
The human colonic mucosa contains regulatory type 1-like (Tr1-like, i.e., IL-10-secreting and Foxp3-negative) T cells specific for the gut Clostridiu…
Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ…
PMID: 30431161
Year: 2019
Relationship Type:
Clinical Research
Score: 5.3
Whether human IL-10-producing regulatory T cells ("Tr1") represent a distinct differentiation lineage or an unstable activation stage remains a key u…
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recogn…
PMID: 30068593
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of…
Toll-like receptors 2 and 4 modulate intestinal IL-10 differently in ileum and …
PMID: 29774159
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel diseases are consequence of an intestinal homeostasis breakdown in which innate immune dysregulation is implicated. To…
Adipokine apelin ameliorates chronic colitis in Il-10(-/-) mice by promoting in…
PMID: 29309764
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Both mesenteric adipose tissue (MAT) and lymphatic vessels (LVs) play important roles in the pathogenesis of Crohn's disease (CD), and adipokines hav…
Lactobacillus sakei K17, an inducer of IL-10 expression in antigen-presenting c…
PMID: 27600362
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
To understand the anti-colitic effects of probiotics that up-regulate interleukin (IL)-10 expression in dendritic cells (DCs) and macrophages, we iso…
Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers…
PMID: 27012624
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
The inflammatory process seen in inflammatory bowel disease (IBD) is due to excess production of pro-inflammatory cytokines interleukin-1 (IL-1), IL…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio164514 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio164515 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio164516 | CHEMBL1200348 | Small molecule | SULCONAZOLE NITRATE | 460.77 | C18H16Cl3N3O3S | NEUTRAL | Details |
| bio164517 | CHEMBL495 | Small molecule | ALPROSTADIL | 354.49 | C20H34O5 | ACID | Details |
| bio164518 | CHEMBL4297310 | Small molecule | DORDAVIPRONE | 386.5 | C24H26N4O | NEUTRAL | Details |
| bio164519 | CHEMBL1200574 | Small molecule | SODIUM CHLORIDE | 58.44 | ClNa | -- | Details |
| bio164520 | CHEMBL4650250 | Protein | EFMARODOCOKIN ALFA | -- | -- | -- | Details |
| bio164521 | CHEMBL2108469 | Protein | MUPLESTIM | -- | -- | -- | Details |
| bio164522 | CHEMBL701 | Small molecule | BACLOFEN | 213.66 | C10H12ClNO2 | ZWITTERION | Details |
| bio164523 | CHEMBL2109037 | Protein | ILODECAKIN | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||