| Target ID: | Tar59 |
|---|---|
| ID: | P22301 |
| Target Name: | Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/P22301 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Telmisartan decreases inflammation by modulating TNF-α, IL-10, and RANK/RANKL i…
PMID: 25933964
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Telmisartan is an antihypertensive angiotensin II receptor blocker. This antihypertensive shows antiinflammatory activity. PURPOSE: In th…
Anti-mouse CD52 monoclonal antibody ameliorates iron-deficient anaemia in IL-10…
PMID: 24160470
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated inflammatory disorder that affects millions of people around the world. Lept…
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice…
PMID: 22451924
Year: 2012
Relationship Type:
Correlation Studies
Score: 5.3
To address the role of Tpl2, a MAP3K8 that regulates innate/adaptive immunity and inflammation, in intestinal tumorigenesis, we crossed a Tpl2 KO all…
Selective upregulation of microRNA expression in peripheral blood leukocytes in…
PMID: 22043014
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
IL-10(-/-) mice, an animal model of Th1-mediated inflammatory bowel disease, were screened for the expression of 600 microRNAs (miRNAs) using colonic…
Apoptosis resistance of mucosal lymphocytes and IL-10 deficiency in patients wi…
PMID: 21674705
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Apoptosis resistance of T-cells is considered an abnormality of immune pathways in Crohn's disease (CD). It has been previously shown tha…
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent an…
PMID: 29725003
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND AND AIMS: Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy, since it has many advantages. However, t…
Long-term vitamin D3 supplementation does not prevent colonic inflammation or m…
PMID: 25247786
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.0
Recent clinical trials in patients with inflammatory diseases like multiple sclerosis (MS) or inflammatory bowel disease (IBD) have shown the benefi…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio164514 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio164515 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio164516 | CHEMBL1200348 | Small molecule | SULCONAZOLE NITRATE | 460.77 | C18H16Cl3N3O3S | NEUTRAL | Details |
| bio164517 | CHEMBL495 | Small molecule | ALPROSTADIL | 354.49 | C20H34O5 | ACID | Details |
| bio164518 | CHEMBL4297310 | Small molecule | DORDAVIPRONE | 386.5 | C24H26N4O | NEUTRAL | Details |
| bio164519 | CHEMBL1200574 | Small molecule | SODIUM CHLORIDE | 58.44 | ClNa | -- | Details |
| bio164520 | CHEMBL4650250 | Protein | EFMARODOCOKIN ALFA | -- | -- | -- | Details |
| bio164521 | CHEMBL2108469 | Protein | MUPLESTIM | -- | -- | -- | Details |
| bio164522 | CHEMBL701 | Small molecule | BACLOFEN | 213.66 | C10H12ClNO2 | ZWITTERION | Details |
| bio164523 | CHEMBL2109037 | Protein | ILODECAKIN | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||