| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Ophiopogonis Radix fructan-selenium nanoparticles for dual amelioration of ulce…
PMID: 40118427
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Fructans demonstrate significant potential in preclinical models for treating inflammatory bowel disease and colorectal cancer by modulating gut micr…
Discovery of a selective NLRP3-targeting compound with therapeutic activity in …
PMID: 37498355
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.0
The aberrant activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is known…
Selective IL-23 Inhibition by Risankizumab Modulates the Molecular Profile in t…
PMID: 30032288
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND AND AIMS: We aimed to investigate the underlying mechanism of action of risankizumab, a monoclonal antibody targeting the IL-23 p19 subuni…
Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mic…
PMID: 29375374
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
Purinergic receptors are implicated in the pathogenesis of gastrointestinal disorders and are being explored as potential therapeutic targets. Gut …
Selective inhibition of mucosal serotonin as treatment for IBD?
PMID: 23868328
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND & AIMS: Severe forms of inflammatory bowel disease (IBD) that develop in very young children can be caused by variants in a single gene. …
Altered IgG(4) renal clearance in patients with inflammatory bowel diseases. Ev…
PMID: 10727544
Year: 2000
Relationship Type:
Therapeutic Applications
Score: 5.0
NK cells are a major component of the innate immune system and play an important role in the tissue inflammation associated with autoimmune diseases…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||