| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Im…
PMID: 30612879
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Several large-scale genome-wide association studies genetically linked IRGM to Crohn's disease and other inflammatory disorders in which the IRGM app…
Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy…
PMID: 30351001
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set of client proteins associated with some diseases, including cancer, pri…
Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orp…
PMID: 30134246
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND/AIMS: Retinoid-related orphan receptor gamma t (RORgammat) is a master regulator of T helper 17 cells that plays a pivotal role in the pro…
Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific ant…
PMID: 29183643
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
In T lymphocytes, expression of miR-148a is induced by T-bet and Twist1, and is specific for pro-inflammatory Th1 cells. In these cells, miR-148a inh…
GSK2586184, a JAK1 selective inhibitor, in two patients with ulcerative colitis
PMID: 28790099
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
Tofacitinib, a non-selective Janus kinase (JAK) inhibitor, is effective in inducing clinical and endoscopic remission in patients with active ulcerat…
High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patient…
PMID: 28110099
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers in the intestine in postprandial conditions. In the las…
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a No…
PMID: 27652492
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
As a continuation of previous efforts in mapping functional hot spots on the bile acid scaffold, we here demonstrate that the introduction of a hydro…
Magnetic resonance enterography is feasible and reliable in multicenter clinica…
PMID: 26548868
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Reliable tools for patient selection are critical for clinical drug trials. AIM: To evaluate a consensus-based, standardised magnetic res…
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytoki…
PMID: 24821797
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development …
Selenium and selenoproteins in inflammatory bowel diseases and experimental col…
PMID: 24694793
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Inadequate dietary intake of the essential trace element selenium (Se) is thought to be a risk factor for several chronic diseases associated with ox…
SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid m…
PMID: 24351663
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The principal diagnosis/indication for this assessment is chronic diarrhoea due to bile acid malabsorption (BAM). Diarrhoea can be define…
Molecular imaging of inflammation in inflammatory bowel disease with a clinical…
PMID: 23371306
Year: 2013
Relationship Type:
Target Validation
Score: 5.3
PURPOSE: To develop and test a molecular imaging approach that uses ultrasonography (US) and a clinically translatable dual-targeted (P- and E-select…
Selective Granulocyte and Monocyte Apheresis as a Non-Pharmacological Option fo…
PMID: 22969694
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.3
Ulcerative colitis and Crohn's disease are the two most prevalent inflammatory bowel diseases. In both cases, the medically refractory and steroid-de…
Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tr…
PMID: 22796107
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) which bind estr…
Selective upregulation of microRNA expression in peripheral blood leukocytes in…
PMID: 22043014
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
IL-10(-/-) mice, an animal model of Th1-mediated inflammatory bowel disease, were screened for the expression of 600 microRNAs (miRNAs) using colonic…
Immunomodulatory effects of unselected haematopoietic stem cells autotransplant…
PMID: 21907652
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Autologous haematopoietic stem cells transplantation (HSCT) has been shown to be effective in refractory Crohn's disease. AIM: We analyse…
GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine recept…
PMID: 20582872
Year: 2010
Relationship Type:
Therapeutic Applications
Score: 5.3
GSK-1605786 (CCX-282; Traficet-EN), a selective antagonist of the CC chemokine receptor (CCR9), is being developed by GlaxoSmithKline plc under licen…
Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly …
PMID: 20218619
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.3
The p38alpha mitogen-activated protein (MAP) kinase is a central signaling molecule in many proinflammatory pathways, regulating the cellular respons…
Central effects of selective NK1 and NK3 tachykinin receptor agonists on two mo…
PMID: 12948843
Year: 2003
Relationship Type:
Correlation Studies
Score: 5.3
Based on the assumption that the delivery of ellagic acid to its site of action would show an antiinflammatory activity in inflammatory bowel diseas…
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.2
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||