| bacA |
ARO:3002986 |
153,972 |
peptide antibiotic |
antibiotic target alteration |
undecaprenyl pyrophosphate related proteins |
| tet(38) |
ARO:3000565 |
3 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-33 |
ARO:3001895 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-32 |
ARO:3001894 |
284 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| OXA-21 |
ARO:3001416 |
4 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| PDC-3 |
ARO:3002500 |
1 |
monobactam; carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
PDC beta-lactamase |
| tet(40) |
ARO:3000567 |
2 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-35 |
ARO:3001897 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-30 |
ARO:3001892 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| mphC |
ARO:3000319 |
3 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| mphB |
ARO:3000318 |
572 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| mdtF |
ARO:3000796 |
151,746 |
macrolide antibiotic; fluoroquinolone antibiotic; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| QnrB19 |
ARO:3002734 |
16 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| mdtE |
ARO:3000795 |
151,865 |
macrolide antibiotic; fluoroquinolone antibiotic; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| QnrB20 |
ARO:3002735 |
107 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| mdtC |
ARO:3000794 |
153,099 |
aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| mdtB |
ARO:3000793 |
151,866 |
aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-20 |
ARO:3001882 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| OXA-10 |
ARO:3001405 |
1,256 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| CTX-M-27 |
ARO:3001889 |
3,619 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
CTX-M beta-lactamase |
| mphA |
ARO:3000316 |
24,388 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| OXA-9 |
ARO:3001404 |
119 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| vanT gene in vanG cluster |
ARO:3002972 |
5 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; vanT |
| CTX-M-25 |
ARO:3001887 |
5 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| QnrB17 |
ARO:3002732 |
19 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| CTX-M-24 |
ARO:3001886 |
326 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| mdtA |
ARO:3000792 |
152,077 |
aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-19 |
ARO:3001881 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-17 |
ARO:3001880 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-16 |
ARO:3001879 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| aadA8b |
ARO:3004704 |
56 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| NDM-1 |
ARO:3000589 |
817 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| kdpE |
ARO:3003841 |
151,847 |
aminoglycoside antibiotic |
antibiotic efflux |
kdpDE |
| QnrB38 |
ARO:3002753 |
2 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| leuO |
ARO:3003843 |
152,806 |
nucleoside antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| OXA-24 |
ARO:3001419 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| OXA-23 |
ARO:3001418 |
11 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| gadW |
ARO:3003838 |
88,856 |
macrolide antibiotic; fluoroquinolone antibiotic; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Mrx |
ARO:3003839 |
24,114 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| mdtM |
ARO:3001214 |
131,749 |
fluoroquinolone antibiotic; lincosamide antibiotic; nucleoside antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| AAC(6')-Ib |
ARO:3002546 |
30 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| QnrD1 |
ARO:3002788 |
89 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| AAC(6')-Ib-cr1 |
ARO:3002547 |
24 |
fluoroquinolone antibiotic; aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6'); AAC(6')-Ib-cr |
| QnrD2 |
ARO:3002789 |
1 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| AAC(6')-Ic |
ARO:3002549 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| tet(X4) |
ARO:3004720 |
645 |
glycylcycline; tetracycline antibiotic |
antibiotic inactivation |
tetracycline inactivation enzyme |
| mdtH |
ARO:3001216 |
152,500 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| AAC(6')-Ia |
ARO:3002545 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| QnrB69 |
ARO:3002781 |
2 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| AAC(3)-VIa |
ARO:3002540 |
2,112 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| OXA-140 |
ARO:3001452 |
25 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| EreB |
ARO:3000363 |
19 |
macrolide antibiotic |
antibiotic inactivation |
macrolide esterase |
| EreA |
ARO:3000361 |
66 |
macrolide antibiotic |
antibiotic inactivation |
macrolide esterase |
| AAC(3)-IVa |
ARO:3002539 |
3,123 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| AAC(3)-IIc |
ARO:3002535 |
330 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| QnrB65 |
ARO:3002777 |
1 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| ErmT |
ARO:3000595 |
36 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| AAC(3)-Ic |
ARO:3002531 |
10 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| BRP(MBL) |
ARO:3001205 |
1,226 |
glycopeptide antibiotic |
antibiotic inactivation |
Bleomycin resistant protein |
| AAC(3)-IIb |
ARO:3002534 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| AAC(3)-Ib |
ARO:3002530 |
11 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| OXA-101 |
ARO:3001439 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| AAC(3)-Ia |
ARO:3002528 |
26 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| Escherichia coli PtsI with mutation conferring resistance to fosfomycin |
ARO:3003899 |
10,939 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant ptsI phosphotransferase |
| MCR-3.5 |
ARO:3004505 |
58 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-1.9 |
ARO:3004507 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| KPC-18 |
ARO:3002328 |
5 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| KPC-12 |
ARO:3002322 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| FosA |
ARO:3000149 |
1 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| ACT-38 |
ARO:3003655 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
ACT beta-lactamase |
| CTX-M-166 |
ARO:3003650 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CMY-132 |
ARO:3003652 |
11,791 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| Escherichia coli UhpT with mutation conferring resistance to fosfomycin |
ARO:3003890 |
21,887 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant UhpT |
| QnrVC1 |
ARO:3002799 |
7 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| MexB |
ARO:3000378 |
2 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-163 |
ARO:3003647 |
11 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| Escherichia coli GlpT with mutation conferring resistance to fosfomycin |
ARO:3003889 |
136,431 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant GlpT |
| MexA |
ARO:3000377 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| KPC-6 |
ARO:3002316 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| CTX-M-164 |
ARO:3003648 |
6 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| ErmB |
ARO:3000375 |
3,782 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| KPC-2 |
ARO:3002312 |
762 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| KPC-3 |
ARO:3002313 |
146 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| KPC-4 |
ARO:3002314 |
13 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| OprM |
ARO:3000379 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| QnrS2 |
ARO:3002791 |
483 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| QnrS4 |
ARO:3002793 |
25 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| OXA-484 |
ARO:3003641 |
86 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| QnrS5 |
ARO:3002794 |
1 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| QnrS1 |
ARO:3002790 |
10,761 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| TriA |
ARO:3003679 |
1 |
disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| tet(D) |
ARO:3000168 |
583 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| TEM-148 |
ARO:3001015 |
6 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| tet(C) |
ARO:3000167 |
934 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-195 |
ARO:3005618 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| tet(B) |
ARO:3000166 |
20,477 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-194 |
ARO:3005617 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-189 |
ARO:3005612 |
8 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-I33 |
ARO:3002587 |
9 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| CTX-M-188 |
ARO:3005611 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ib' |
ARO:3003676 |
2 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| CTX-M-191 |
ARO:3005614 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-190 |
ARO:3005613 |
7 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| GES-11 |
ARO:3002340 |
5 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
GES beta-lactamase |
| AAC(6')-29b |
ARO:3002584 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| AAC(6')-31 |
ARO:3002585 |
2 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| tet(A) |
ARO:3000165 |
39,057 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| TEM-145 |
ARO:3001012 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| AAC(6')-Ib9 |
ARO:3002580 |
354 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| AAC(6')-Ib10 |
ARO:3002581 |
690 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| CTX-M-186 |
ARO:3005609 |
23 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ib8 |
ARO:3002579 |
69 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| CTX-M-182 |
ARO:3005605 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| MCR-8.1 |
ARO:3004516 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| TEM-141 |
ARO:3001004 |
13 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-181 |
ARO:3005604 |
6 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| MCR-1.4 |
ARO:3004515 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CTX-M-178 |
ARO:3005601 |
14 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Iai |
ARO:3002575 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| MCR-3.2 |
ARO:3004511 |
16 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| GES-5 |
ARO:3002334 |
14 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
GES beta-lactamase |
| AAC(6')-Ib3 |
ARO:3002576 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| NmcR |
ARO:3003665 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NmcA beta-lactamase |
| AAC(6')-Ib4 |
ARO:3002577 |
9 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| AAC(6')-Ib7 |
ARO:3002578 |
16 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| TEM-143 |
ARO:3001006 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-179 |
ARO:3005602 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| norA |
ARO:3000391 |
1 |
fluoroquinolone antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| GES-1 |
ARO:3002330 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
GES beta-lactamase |
| AAC(6')-Iaf |
ARO:3002574 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| NDM-15 |
ARO:3003663 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-136 |
ARO:3001000 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| KLUC-3 |
ARO:3006929 |
2 |
cephalosporin |
antibiotic inactivation |
KLUC beta-lactamase |
| TEM-171 |
ARO:3001037 |
7 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| dfrA9 |
ARO:3004548 |
3 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| CTX-M-216 |
ARO:3005639 |
18 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-169 |
ARO:3001035 |
62 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-211 |
ARO:3005634 |
9 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| mexP |
ARO:3003698 |
1 |
macrolide antibiotic; carbapenem; tetracycline antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| dfrA6 |
ARO:3004547 |
4 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| mexQ |
ARO:3003699 |
1 |
macrolide antibiotic; carbapenem; tetracycline antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-164 |
ARO:3001030 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MexK |
ARO:3003693 |
1 |
macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| FosA4 |
ARO:3003210 |
185 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| tet(Y) |
ARO:3000182 |
50 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| PER-2 |
ARO:3002364 |
6 |
monobactam; carbapenem; cephalosporin; penam; penem |
antibiotic inactivation |
PER beta-lactamase |
| CMY-111 |
ARO:3002122 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CTX-M-208 |
ARO:3005631 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-168 |
ARO:3001034 |
6 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| tet(M) |
ARO:3000186 |
2,608 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| TEM-166 |
ARO:3001032 |
20 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MexJ |
ARO:3003692 |
1 |
macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| NDM-9 |
ARO:3002359 |
136 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| CTX-M-206 |
ARO:3005629 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| fosA5 |
ARO:3003209 |
39 |
fluoroquinolone antibiotic; aminoglycoside antibiotic; phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| tet(J) |
ARO:3000177 |
2 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| NDM-4 |
ARO:3002355 |
61 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
NDM beta-lactamase |
| CTX-M-200 |
ARO:3005623 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ie-APH(2'')-Ia bifunctional protein |
ARO:3002597 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
aminoglycoside bifunctional resistance protein |
| CTX-M-199 |
ARO:3005622 |
95 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| NDM-6 |
ARO:3002356 |
9 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-163 |
ARO:3001029 |
94 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| NDM-7 |
ARO:3002357 |
250 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| MCR-1.1 |
ARO:3003689 |
3,879 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| OpmH |
ARO:3003682 |
1 |
disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| AAC(6')-IIa |
ARO:3002594 |
10 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| cfrA |
ARO:3003441 |
23 |
lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; oxazolidinone antibiotic; phenicol antibiotic; pleuromutilin antibiotic |
antibiotic target alteration |
Cfr 23S ribosomal RNA methyltransferase |
| CTX-M-198 |
ARO:3005621 |
7 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ian |
ARO:3003200 |
6 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| CTX-M-197 |
ARO:3005620 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-IIc |
ARO:3002596 |
70 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| NDM-3 |
ARO:3002354 |
5 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| tet(H) |
ARO:3000175 |
7 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| TEM-156 |
ARO:3001022 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TriB |
ARO:3003680 |
1 |
disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| tet(E) |
ARO:3000173 |
5 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| TriC |
ARO:3003681 |
1 |
disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-154 |
ARO:3001020 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| SHV-1 |
ARO:3001059 |
148 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| CTX-M-236 |
ARO:3005659 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-198 |
ARO:3001057 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-232 |
ARO:3005655 |
5 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| OXY-1-1 |
ARO:3002389 |
1 |
monobactam; cephalosporin; penam |
antibiotic inactivation |
OXY beta-lactamase |
| tetR |
ARO:3003479 |
20,476 |
tetracycline antibiotic |
antibiotic target alteration; antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| ICR-Mo |
ARO:3004569 |
5 |
peptide antibiotic |
antibiotic target alteration |
intrinsic colistin resistant phosphoethanolamine transferase |
| SFO-1 |
ARO:3006986 |
24 |
carbapenem |
antibiotic inactivation |
SFO beta-lactamase |
| CTX-M-235 |
ARO:3005658 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| BEL-1 |
ARO:3002385 |
2 |
monobactam; cephalosporin; penam |
antibiotic inactivation |
BEL beta-lactamase |
| TEM-191 |
ARO:3001051 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-190 |
ARO:3001050 |
170 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-231 |
ARO:3005654 |
44 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| DHA-14 |
ARO:3002145 |
1 |
cephalosporin; cephamycin |
antibiotic inactivation |
DHA beta-lactamase |
| CTX-M-226 |
ARO:3005649 |
7 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-186 |
ARO:3001046 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| VEB-8 |
ARO:3002377 |
1 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| dfrA32 |
ARO:3004555 |
14 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| DHA-7 |
ARO:3002136 |
4 |
cephalosporin; cephamycin |
antibiotic inactivation |
DHA beta-lactamase |
| VEB-9 |
ARO:3002378 |
2 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| CTX-M-224 |
ARO:3005647 |
5 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-223 |
ARO:3005646 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-176 |
ARO:3001041 |
236 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| tet(W) |
ARO:3000194 |
8 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| DHA-1 |
ARO:3002132 |
1,169 |
cephalosporin; cephamycin |
antibiotic inactivation |
DHA beta-lactamase |
| VEB-5 |
ARO:3002375 |
2 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| CTX-M-220 |
ARO:3005643 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| tet(Q) |
ARO:3000191 |
21 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| TEM-183 |
ARO:3001045 |
5 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-181 |
ARO:3001044 |
14 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| VEB-1 |
ARO:3002370 |
10 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| dfrA27 |
ARO:3004550 |
450 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| tet(32) |
ARO:3000196 |
2 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| tetB(P) |
ARO:3000195 |
1 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| tet(O) |
ARO:3000190 |
4 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| dfrA23 |
ARO:3003019 |
44 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| dfrA19 |
ARO:3003015 |
138 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| Klebsiella pneumoniae KpnG |
ARO:3004588 |
5 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| dfrA21 |
ARO:3003017 |
34 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| Pseudomonas aeruginosa soxR |
ARO:3004107 |
1 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| dfrA10 |
ARO:3003011 |
18 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| dfrA15 |
ARO:3003013 |
328 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| QepA2 |
ARO:3004103 |
212 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| SHV-12 |
ARO:3001071 |
759 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| dfrA16 |
ARO:3003014 |
30 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| Klebsiella pneumoniae KpnE |
ARO:3004580 |
153,528 |
macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| SHV-19 |
ARO:3001077 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| Klebsiella pneumoniae KpnF |
ARO:3004583 |
153,830 |
macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| SHV-11 |
ARO:3001070 |
28 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| Escherichia coli gyrA with mutation conferring resistance to triclosan |
ARO:3004335 |
721 |
disinfecting agents and antiseptics |
antibiotic target alteration |
triclosan resistant gyrA |
| CTX-M-244 |
ARO:3005666 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| FOX-5 |
ARO:3002159 |
13 |
cephalosporin; cephamycin |
antibiotic inactivation |
FOX beta-lactamase |
| CTX-M-240 |
ARO:3005663 |
5 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| MCR-5.1 |
ARO:3004332 |
54 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| Acinetobacter baumannii AbaQ |
ARO:3004574 |
1 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-239 |
ARO:3005662 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| SHV-2A |
ARO:3001061 |
92 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| CTX-M-242 |
ARO:3005665 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| SHV-2 |
ARO:3001060 |
23 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| SHV-8 |
ARO:3001067 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| SHV-7 |
ARO:3001066 |
14 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| CTX-M-238 |
ARO:3005661 |
10 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| Staphylococcus aureus LmrS |
ARO:3004572 |
1 |
macrolide antibiotic; aminoglycoside antibiotic; oxazolidinone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| SHV-5 |
ARO:3001064 |
23 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| DHA-21 |
ARO:3002152 |
1 |
cephalosporin; cephamycin |
antibiotic inactivation |
DHA beta-lactamase |
| CMY-59 |
ARO:3002069 |
26 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| SHV-187 |
ARO:3003154 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| TEM-219 |
ARO:3003157 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics |
ARO:3003390 |
4 |
monobactam; carbapenem; cephalosporin; cephamycin; penam; penem |
reduced permeability to antibiotic |
General Bacterial Porin with reduced permeability to beta-lactams |
| CMY-48 |
ARO:3002059 |
3 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-43 |
ARO:3002054 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| Escherichia coli folP with mutation conferring resistance to sulfonamides |
ARO:3003386 |
69 |
sulfonamide antibiotic |
antibiotic target alteration |
sulfonamide resistant dihydropteroate synthase folP |
| CMY-44 |
ARO:3002055 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| KPC-21 |
ARO:3003145 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| VIM-29 |
ARO:3002299 |
3 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
VIM beta-lactamase |
| Escherichia coli soxR with mutation conferring antibiotic resistance |
ARO:3003381 |
152,476 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CMY-42 |
ARO:3002053 |
891 |
cephalosporin; cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| AAC(6')-Ib-cr6 |
ARO:3005116 |
8,406 |
fluoroquinolone antibiotic; aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6'); AAC(6')-Ib-cr |
| CTX-M-174 |
ARO:3005597 |
28 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ib-cr3 |
ARO:3005112 |
24 |
fluoroquinolone antibiotic; aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6'); AAC(6')-Ib-cr |
| dfr22 |
ARO:3005354 |
6 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| CTX-M-173 |
ARO:3005596 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AAC(6')-Ib-cr5 |
ARO:3005115 |
11 |
fluoroquinolone antibiotic; aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6'); AAC(6')-Ib-cr |
| AAC(6')-Ib-cr4 |
ARO:3005114 |
94 |
fluoroquinolone antibiotic; aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6'); AAC(6')-Ib-cr |
| CTX-M-170 |
ARO:3005593 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| DfrB9 |
ARO:3005350 |
19 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| CTX-M-169 |
ARO:3005592 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CMY-131 |
ARO:3003170 |
12 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-69 |
ARO:3002082 |
3 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| DfrA36 |
ARO:3005348 |
550 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| DfrA37 |
ARO:3005347 |
20 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| CTX-M-157 |
ARO:3003165 |
9 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| DfrA34 |
ARO:3005346 |
17 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| dfrB4 |
ARO:3004498 |
51 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| CARB-53 |
ARO:3005587 |
90 |
penam |
antibiotic inactivation |
CARB beta-lactamase |
| CMY-58 |
ARO:3002072 |
4 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-61 |
ARO:3002074 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-62 |
ARO:3002075 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| TEM-52 |
ARO:3000921 |
196 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| FRI-10 |
ARO:3006227 |
1 |
penam |
antibiotic inactivation |
FRI beta-lactamase |
| ACC-1a |
ARO:3006228 |
13 |
monobactam; cephalosporin; penam |
antibiotic inactivation |
ACC beta-lactamase |
| Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan |
ARO:3004045 |
26 |
disinfecting agents and antiseptics; isoniazid-like antibiotic |
antibiotic target alteration |
antibiotic resistant fabI |
| DHA-27 |
ARO:3006468 |
2 |
cephalosporin; cephamycin |
antibiotic inactivation |
DHA beta-lactamase |
| KPC-49 |
ARO:3005378 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| CMY-174 |
ARO:3006463 |
30 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| Enterobacter cloacae acrA |
ARO:3004042 |
2 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| NDM-29 |
ARO:3005131 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| aadA25 |
ARO:3003197 |
10 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| Escherichia coli acrA |
ARO:3004043 |
153,931 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| VEB-25 |
ARO:3006220 |
2 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| Escherichia coli emrE |
ARO:3004039 |
95,281 |
macrolide antibiotic |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| TEM-40 |
ARO:3000910 |
162 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Pseudomonas aeruginosa emrE |
ARO:3004038 |
1 |
aminoglycoside antibiotic |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| QnrB76 |
ARO:3003188 |
53 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| VEB-17 |
ARO:3006213 |
5 |
monobactam; cephalosporin |
antibiotic inactivation |
VEB beta-lactamase |
| CMY-81 |
ARO:3002094 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| KPC-31 |
ARO:3005362 |
1 |
monobactam; carbapenem; cephalosporin; penam |
antibiotic inactivation |
KPC beta-lactamase |
| TEM-39 |
ARO:3000909 |
16 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| NDM-13 |
ARO:3003182 |
18 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-33 |
ARO:3000903 |
54 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-32 |
ARO:3000902 |
66 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-31 |
ARO:3000901 |
11 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-30 |
ARO:3000900 |
171 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-37 |
ARO:3000907 |
5 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-36 |
ARO:3000906 |
4 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-35 |
ARO:3000905 |
57 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-34 |
ARO:3000904 |
32 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Type B NfxB |
ARO:3004060 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-70 |
ARO:3000936 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-73 |
ARO:3000939 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Pseudomonas aeruginosa CpxR |
ARO:3004054 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Escherichia coli ampC beta-lactamase |
ARO:3004290 |
17,906 |
cephalosporin; penam |
antibiotic inactivation |
ampC-type beta-lactamase |
| TEM-55 |
ARO:3000924 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-54 |
ARO:3000923 |
5 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-57 |
ARO:3000926 |
47 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| OXA-129 |
ARO:3001811 |
3 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| TEM-95 |
ARO:3000962 |
5 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| ANT(3'')-IIa |
ARO:3004089 |
19,644 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| ACT-74 |
ARO:3006268 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
ACT beta-lactamase |
| lnuG |
ARO:3004085 |
387 |
lincosamide antibiotic |
antibiotic inactivation |
lincosamide nucleotidyltransferase (LNU) |
| CMY-173 |
ARO:3005177 |
5 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| nimE |
ARO:3007107 |
1 |
nitroimidazole antibiotic |
antibiotic inactivation |
nitroimidazole reductase |
| TEM-84 |
ARO:3000951 |
24 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MuxC |
ARO:3004075 |
1 |
macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| dfrA35 |
ARO:3005164 |
3 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| MuxB |
ARO:3004074 |
1 |
macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| PmpM |
ARO:3004077 |
1 |
fluoroquinolone antibiotic; aminoglycoside antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
multidrug and toxic compound extrusion (MATE) transporter |
| FosA7.5 |
ARO:3005162 |
1,259 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| MuxA |
ARO:3004073 |
1 |
macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| OpmB |
ARO:3004072 |
1 |
macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-79 |
ARO:3000946 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-120 |
ARO:3000982 |
11 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| vanR gene in vanB cluster |
ARO:3002921 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; vanR |
| AcrF |
ARO:3000502 |
124,210 |
fluoroquinolone antibiotic; cephalosporin; cephamycin; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-122 |
ARO:3000984 |
15 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| mcr-10.1 |
ARO:3007137 |
13 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-145 |
ARO:3005197 |
209 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-141 |
ARO:3005196 |
40 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-171 |
ARO:3005199 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-163 |
ARO:3005193 |
8 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-148 |
ARO:3005192 |
19 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| FosI |
ARO:3007370 |
4 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| FosA8 |
ARO:3007371 |
74 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| CMY-154 |
ARO:3005194 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| TEM-116 |
ARO:3000979 |
57 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| ACT-2 |
ARO:3001822 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
ACT beta-lactamase |
| TEM-110 |
ARO:3000973 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CMY-166 |
ARO:3005189 |
8 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| FosG |
ARO:3007368 |
5 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| CMY-140 |
ARO:3005185 |
3 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-165 |
ARO:3005188 |
7 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| tet(O/W) |
ARO:3007121 |
1 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| CMY-156 |
ARO:3005182 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-146 |
ARO:3005181 |
33 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-162 |
ARO:3005184 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-160 |
ARO:3005183 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| ANT(3'')-IIc |
ARO:3004091 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| TEM-106 |
ARO:3000969 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-105 |
ARO:3000968 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-104 |
ARO:3000967 |
32 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| vanG |
ARO:3002909 |
153,870 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; Van ligase |
| vanH gene in vanB cluster |
ARO:3002943 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanH; glycopeptide resistance gene cluster |
| ErmG |
ARO:3000522 |
4 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| OXA-58 |
ARO:3001611 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| CRP |
ARO:3000518 |
154,054 |
macrolide antibiotic; fluoroquinolone antibiotic; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| emrR |
ARO:3000516 |
153,805 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| TEM-135 |
ARO:3000999 |
552 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| vanS gene in vanB cluster |
ARO:3002932 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanS; glycopeptide resistance gene cluster |
| ACT-24 |
ARO:3001844 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
ACT beta-lactamase |
| TEM-128 |
ARO:3000990 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| ACT-17 |
ARO:3001838 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
ACT beta-lactamase |
| MexR |
ARO:3000506 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem |
antibiotic target alteration; antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-127 |
ARO:3000989 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| mepR |
ARO:3000746 |
3 |
glycylcycline; tetracycline antibiotic |
antibiotic efflux |
multidrug and toxic compound extrusion (MATE) transporter |
| gadX |
ARO:3000508 |
152,069 |
macrolide antibiotic; fluoroquinolone antibiotic; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| vanW gene in vanB cluster |
ARO:3002964 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanW; glycopeptide resistance gene cluster |
| vanW gene in vanG cluster |
ARO:3002965 |
2 |
glycopeptide antibiotic |
antibiotic target alteration |
vanW; glycopeptide resistance gene cluster |
| QnrB10 |
ARO:3002724 |
1,720 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| CTX-M-9 |
ARO:3001872 |
92 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| OXA-95 |
ARO:3001630 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| CTX-M-8 |
ARO:3001871 |
176 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-15 |
ARO:3001878 |
15,594 |
cephalosporin; penam |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-14 |
ARO:3001877 |
4,053 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| vanY gene in vanM cluster |
ARO:3002961 |
2 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| QnrB6 |
ARO:3002720 |
114 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| CTX-M-13 |
ARO:3001876 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-12 |
ARO:3001875 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| QnrB5 |
ARO:3002719 |
282 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| CTX-M-5 |
ARO:3001868 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| QnrB2 |
ARO:3002715 |
6 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| vanY gene in vanG cluster |
ARO:3002959 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| QnrB4 |
ARO:3002718 |
1,168 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime |
ARO:3003807 |
151,095 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| QnrA6 |
ARO:3002712 |
2 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| vanY gene in vanA cluster |
ARO:3002955 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| QnrB1 |
ARO:3002714 |
271 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| vanY gene in vanB cluster |
ARO:3002956 |
5 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| CTX-M-3 |
ARO:3001866 |
385 |
cephalosporin; cephamycin; penam |
antibiotic inactivation |
CTX-M beta-lactamase |
| adeF |
ARO:3000777 |
110 |
fluoroquinolone antibiotic; tetracycline antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| vanX gene in vanB cluster |
ARO:3002950 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanX; glycopeptide resistance gene cluster |
| CTX-M-2 |
ARO:3001865 |
346 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-1 |
ARO:3001864 |
1,822 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| QnrA3 |
ARO:3002709 |
2 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| IMI-2 |
ARO:3001859 |
1 |
carbapenem |
antibiotic inactivation |
IMI beta-lactamase |
| fexA |
ARO:3002704 |
2 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| floR |
ARO:3002705 |
13,945 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| QnrA1 |
ARO:3002707 |
261 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| ANT(4')-Ia |
ARO:3002623 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(4') |
| dfrG |
ARO:3002868 |
1 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| ANT(6)-Ia |
ARO:3002626 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(6) |
| emrK |
ARO:3000206 |
151,591 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| msbA |
ARO:3003950 |
153,966 |
nitroimidazole antibiotic |
antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump |
| dfrA5 |
ARO:3002861 |
2,194 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| OXA-232 |
ARO:3001778 |
55 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| dfrA7 |
ARO:3002862 |
1,479 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| aadA23 |
ARO:3002620 |
819 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| dfrA8 |
ARO:3002863 |
1,690 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| YojI |
ARO:3003952 |
153,417 |
peptide antibiotic |
antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump |
| aadA24 |
ARO:3002621 |
81 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| MexL |
ARO:3003710 |
1 |
macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| aadA6/aadA10 |
ARO:3002622 |
77 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| OXA-162 |
ARO:3001776 |
3 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| dfrA17 |
ARO:3002860 |
16,799 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| MexZ |
ARO:3003709 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| aadA16 |
ARO:3002616 |
425 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| dfrA12 |
ARO:3002858 |
9,806 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| mexN |
ARO:3003705 |
1 |
phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| dfrA14 |
ARO:3002859 |
7,347 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| aadA17 |
ARO:3002617 |
329 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA22 |
ARO:3002619 |
335 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| dfrA1 |
ARO:3002854 |
10,175 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| aadA12 |
ARO:3002612 |
180 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA13 |
ARO:3002613 |
69 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| dfrA24 |
ARO:3002856 |
20 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| aadA15 |
ARO:3002615 |
39 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| dfrA26 |
ARO:3002857 |
1 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| mexM |
ARO:3003704 |
1 |
phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| H-NS |
ARO:3000676 |
153,935 |
macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| aadA11 |
ARO:3002611 |
5 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA5 |
ARO:3002605 |
14,904 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| arr-2 |
ARO:3002847 |
1,491 |
rifamycin antibiotic |
antibiotic inactivation |
rifampin ADP-ribosyltransferase (Arr) |
| arr-3 |
ARO:3002848 |
1,290 |
rifamycin antibiotic |
antibiotic inactivation |
rifampin ADP-ribosyltransferase (Arr) |
| aadA6 |
ARO:3002606 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA7 |
ARO:3002607 |
136 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA8 |
ARO:3002608 |
5 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| APH(3')-IIb |
ARO:3002645 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| OXA-50 |
ARO:3001796 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| LAP-2 |
ARO:3004826 |
359 |
cephalosporin; penam; penem |
antibiotic inactivation |
LAP beta-lactamase |
| APH(3')-IIIa |
ARO:3002647 |
44 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| LAP-1 |
ARO:3004825 |
13 |
cephalosporin; penam; penem |
antibiotic inactivation |
LAP beta-lactamase |
| APH(3')-Ia |
ARO:3002641 |
11,315 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| APH(3')-Ib |
ARO:3002642 |
15 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| NDM-5 |
ARO:3000467 |
5,133 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| APH(3')-IIa |
ARO:3002644 |
1,526 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| OXA-320 |
ARO:3001793 |
4 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| APH(3'')-Ib |
ARO:3002639 |
38,627 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3'') |
| HERA-3 |
ARO:3004818 |
587 |
penam |
antibiotic inactivation |
HERA beta-lactamase |
| OXA-244 |
ARO:3001786 |
335 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| vanW gene in vanI cluster |
ARO:3003724 |
4 |
glycopeptide antibiotic |
antibiotic target alteration |
vanW; glycopeptide resistance gene cluster |
| OXA-181 |
ARO:3001784 |
671 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| linG |
ARO:3002879 |
2,266 |
lincosamide antibiotic |
antibiotic inactivation |
lincosamide nucleotidyltransferase (LNU) |
| OXA-163 |
ARO:3001783 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| FosA3 |
ARO:3002872 |
2,567 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| acrB |
ARO:3000216 |
153,593 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| OXA-204 |
ARO:3001788 |
9 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| FosC2 |
ARO:3002874 |
1 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosC phosphotransferase family |
| OXA-48 |
ARO:3001782 |
825 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| rmtD |
ARO:3002667 |
1 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| Escherichia coli soxS with mutation conferring antibiotic resistance |
ARO:3003511 |
153,925 |
fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic |
ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams |
| rmtF |
ARO:3002666 |
11 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| OXA-392 |
ARO:3001578 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| APH(6)-Id |
ARO:3002660 |
39,247 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(6) |
| Escherichia coli nfsA mutations conferring resistance to nitrofurantoin |
ARO:3003751 |
568 |
nitrofuran antibiotic |
antibiotic target alteration |
antibiotic resistant nfsA |
| mdtG |
ARO:3001329 |
133,398 |
phosphonic acid antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| mefC |
ARO:3003745 |
36 |
macrolide antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| tet(31) |
ARO:3000476 |
16 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| APH(6)-Ic |
ARO:3002659 |
247 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(6) |
| Escherichia coli mdfA |
ARO:3001328 |
148,166 |
tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| APH(3')-VIa |
ARO:3002652 |
147 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| mphE |
ARO:3003741 |
430 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| APH(3')-VIb |
ARO:3002653 |
15 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| SAT-2 |
ARO:3002895 |
5,790 |
nucleoside antibiotic |
antibiotic inactivation |
streptothricin acetyltransferase (SAT) |
| mphG |
ARO:3003742 |
107 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| TolC |
ARO:3000237 |
153,858 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| APH(4)-Ia |
ARO:3002655 |
2,791 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(4) |
| SAT-4 |
ARO:3002897 |
2 |
nucleoside antibiotic |
antibiotic inactivation |
streptothricin acetyltransferase (SAT) |
| ANT(2'')-Ia |
ARO:3000230 |
857 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(2'') |
| IMP-14 |
ARO:3002205 |
2 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| mepA |
ARO:3000026 |
2 |
glycylcycline; tetracycline antibiotic |
antibiotic efflux |
multidrug and toxic compound extrusion (MATE) transporter |
| SHV-173 |
ARO:3001357 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| Erm(49) |
ARO:3004626 |
2 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| QnrS12 |
ARO:3004625 |
1 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| NDM-24 |
ARO:3004867 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| AAC(2')-IIa |
ARO:3004628 |
61 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(2') |
| OXA-405 |
ARO:3001596 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| NDM-26 |
ARO:3004869 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| NDM-21 |
ARO:3004864 |
3 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| catIII |
ARO:3002685 |
2 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| AAC(3)-IIe |
ARO:3004621 |
4,657 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| NDM-20 |
ARO:3004863 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| IMP-11 |
ARO:3002202 |
2 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| QnrS11 |
ARO:3004624 |
10 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| emrA |
ARO:3000027 |
152,268 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| AAC(3)-IId |
ARO:3004623 |
8,391 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| catI |
ARO:3002683 |
6,384 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| NDM-19 |
ARO:3004862 |
4 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| catII |
ARO:3002684 |
6 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| SHV-53 |
ARO:3001110 |
3 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| marA |
ARO:3000263 |
153,310 |
fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux; reduced permeability to antibiotic |
resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams |
| catB8 |
ARO:3002680 |
10 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| AcrE |
ARO:3000499 |
147,618 |
fluoroquinolone antibiotic; cephalosporin; cephamycin; penam |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| ErmF |
ARO:3000498 |
10 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| SCO-1 |
ARO:3004856 |
3 |
cephalosporin; penam; penem |
antibiotic inactivation |
SCO beta-lactamase |
| Pseudomonas aeruginosa catB7 |
ARO:3002679 |
1 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| OKP-B-5 |
ARO:3002438 |
1 |
cephalosporin; penam |
antibiotic inactivation |
OKP beta-lactamase |
| vanB |
ARO:3000013 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; Van ligase |
| emrY |
ARO:3000254 |
150,300 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| catB2 |
ARO:3002675 |
39 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| catB3 |
ARO:3002676 |
1,304 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| SHV-49 |
ARO:3001106 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| CMY-136 |
ARO:3004854 |
604 |
cephalosporin; cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| acrD |
ARO:3000491 |
152,278 |
aminoglycoside antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| msrA |
ARO:3000251 |
3 |
macrolide antibiotic; streptogramin antibiotic; streptogramin B antibiotic |
antibiotic target protection |
msr-type ABC-F protein |
| ErmC |
ARO:3000250 |
9 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| EreD |
ARO:3004608 |
1 |
macrolide antibiotic |
antibiotic inactivation |
macrolide esterase |
| Escherichia coli parE conferring resistance to fluoroquinolones |
ARO:3003316 |
4 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant parE |
| Salmonella serovars parE conferring resistance to fluoroquinolones |
ARO:3003317 |
4 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant parE |
| cepA |
ARO:3003559 |
1 |
cephalosporin |
antibiotic inactivation |
CepA beta-lactamase |
| IMP-38 |
ARO:3002229 |
3 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| mdtP |
ARO:3003550 |
151,418 |
nucleoside antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| dfrA15b |
ARO:3004640 |
24 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| LEN-13 |
ARO:3002463 |
1 |
penam; penem |
antibiotic inactivation |
LEN beta-lactamase |
| qnrE2 |
ARO:3004637 |
3 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| mdtN |
ARO:3003548 |
152,504 |
nucleoside antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| Morganella morganii gyrB conferring resistance to fluoroquinolones |
ARO:3003306 |
234 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrB |
| IMP-26 |
ARO:3002217 |
3 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| qnrE1 |
ARO:3004636 |
3 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| mdtO |
ARO:3003549 |
150,020 |
nucleoside antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| Salmonella serovars gyrB conferring resistance to fluoroquinolones |
ARO:3003307 |
25 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrB |
| IMP-27 |
ARO:3002218 |
2 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| Escherichia coli parC conferring resistance to fluoroquinolones |
ARO:3003308 |
29,969 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant parC |
| cmlA6 |
ARO:3002696 |
367 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin |
ARO:3003785 |
1 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant murA transferase |
| AAC(6')-Il |
ARO:3004635 |
100 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(6') |
| cmlA1 |
ARO:3002693 |
4,467 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| NDM-27 |
ARO:3004870 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| cmlA4 |
ARO:3002694 |
23 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| cmlA5 |
ARO:3002695 |
1,039 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| OXA-4 |
ARO:3001399 |
22 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| eptA |
ARO:3003576 |
153,269 |
peptide antibiotic |
antibiotic target alteration |
pmr phosphoethanolamine transferase |
| ugd |
ARO:3003577 |
128,490 |
peptide antibiotic |
antibiotic target alteration |
pmr phosphoethanolamine transferase |
| PmrF |
ARO:3003578 |
153,149 |
peptide antibiotic |
antibiotic target alteration |
pmr phosphoethanolamine transferase |
| CTX-M-147 |
ARO:3002005 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| Staphylococcus aureus norA |
ARO:3004667 |
1 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| SHV-102 |
ARO:3001151 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| TEM-215 |
ARO:3001392 |
95 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CARB-3 |
ARO:3002242 |
206 |
penam |
antibiotic inactivation |
CARB beta-lactamase |
| Staphylococcus aureus FosB |
ARO:3004661 |
3 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| CTX-M-142 |
ARO:3002000 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-214 |
ARO:3001391 |
69 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-143 |
ARO:3002001 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-213 |
ARO:3001390 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| OXA-2 |
ARO:3001397 |
87 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| OXA-1 |
ARO:3001396 |
9,761 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| catB11 |
ARO:3004660 |
10 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| TEM-217 |
ARO:3001394 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-212 |
ARO:3001389 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-210 |
ARO:3001387 |
21 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| LEN-14 |
ARO:3002477 |
8 |
penam; penem |
antibiotic inactivation |
LEN beta-lactamase |
| catA4 |
ARO:3004657 |
2 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| catII from Escherichia coli K-12 |
ARO:3004656 |
629 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| TEM-209 |
ARO:3001386 |
361 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-207 |
ARO:3001384 |
5 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-206 |
ARO:3001383 |
31 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics |
ARO:3004446 |
153,646 |
cephalosporin; cephamycin; penam |
antibiotic target alteration |
Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics |
| MCR-1.8 |
ARO:3004687 |
2 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-16 |
ARO:3002027 |
31 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| HERA-1 |
ARO:3004448 |
61 |
penam |
antibiotic inactivation |
HERA beta-lactamase |
| CMY-17 |
ARO:3002028 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| MCR-1.12 |
ARO:3004689 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-9.1 |
ARO:3004684 |
231 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-10 |
ARO:3002021 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| tet(W/N/W) |
ARO:3004442 |
1 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| tet(59) |
ARO:3004441 |
3 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| aadS |
ARO:3004683 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(6) |
| OXA-439 |
ARO:3003595 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| MCR-1.7 |
ARO:3004686 |
11 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-12 |
ARO:3002023 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| MCR-1.5 |
ARO:3004685 |
13 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-13 |
ARO:3002024 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| mef(B) |
ARO:3003107 |
660 |
macrolide antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CMY-7 |
ARO:3002018 |
3 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| msrE |
ARO:3003109 |
441 |
macrolide antibiotic; streptogramin antibiotic |
antibiotic target protection |
msr-type ABC-F protein |
| SHV-120 |
ARO:3001167 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| CMY-4 |
ARO:3002015 |
179 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| Erm(42) |
ARO:3003106 |
384 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| CMY-6 |
ARO:3002017 |
103 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| rmtE |
ARO:3004678 |
17 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| CTX-M-153 |
ARO:3002010 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| basS |
ARO:3003583 |
1 |
peptide antibiotic |
antibiotic target alteration; antibiotic efflux |
pmr phosphoethanolamine transferase |
| aphA15 |
ARO:3004675 |
42 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| CMY-2 |
ARO:3002013 |
5,410 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
CMY beta-lactamase |
| emrB |
ARO:3000074 |
153,379 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| basR |
ARO:3003582 |
1 |
peptide antibiotic |
antibiotic target alteration; antibiotic efflux |
pmr phosphoethanolamine transferase |
| Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline |
ARO:3003378 |
153,299 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CMY-32 |
ARO:3002043 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| CMY-33 |
ARO:3002044 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| EC-8 |
ARO:3006881 |
13,412 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| EC-5 |
ARO:3006880 |
16,251 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance |
ARO:3003373 |
1 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic target alteration; antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| EC-18 |
ARO:3006878 |
5,802 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| EC-19 |
ARO:3006879 |
1,830 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin |
ARO:3003369 |
35,211 |
elfamycin antibiotic |
antibiotic target alteration |
elfamycin resistant EF-Tu |
| EC-15 |
ARO:3006876 |
28,123 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| EC-16 |
ARO:3006877 |
72 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| EC-13 |
ARO:3006874 |
5,390 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| VIM-4 |
ARO:3002274 |
9 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
VIM beta-lactamase |
| EC-14 |
ARO:3006875 |
53,244 |
cephalosporin |
antibiotic inactivation |
EC beta-lactamase |
| MCR-4.2 |
ARO:3004694 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-4.5 |
ARO:3004697 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CMY-24 |
ARO:3002035 |
2 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| MCR-3.4 |
ARO:3004691 |
12 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| VIM-1 |
ARO:3002271 |
87 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
VIM beta-lactamase |
| MCR-3.12 |
ARO:3004693 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| VIM-2 |
ARO:3002272 |
1 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
VIM beta-lactamase |
| aadA10 |
ARO:3004692 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| mexY |
ARO:3003033 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Klebsiella pneumoniae OmpK37 |
ARO:3004122 |
3 |
monobactam; carbapenem; cephalosporin; cephamycin; penam; penem |
reduced permeability to antibiotic |
General Bacterial Porin with reduced permeability to beta-lactams |
| MexV |
ARO:3003030 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexW |
ARO:3003031 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| FosA6 |
ARO:3004111 |
30 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| Klebsiella pneumoniae KpnH |
ARO:3004597 |
477 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| FosA7 |
ARO:3004113 |
11 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| SHV-31 |
ARO:3001089 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| SHV-30 |
ARO:3001088 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
SHV beta-lactamase |
| MCR-2.1 |
ARO:3004110 |
17 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| dfrA25 |
ARO:3003020 |
38 |
diaminopyrimidine antibiotic |
antibiotic target replacement |
trimethoprim resistant dihydrofolate reductase dfr |
| MIR-5 |
ARO:3002170 |
1 |
monobactam; cephalosporin |
antibiotic inactivation |
MIR beta-lactamase |
| IMP-70 |
ARO:3005476 |
1 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| cfrC |
ARO:3004146 |
1 |
lincosamide antibiotic; streptogramin antibiotic; oxazolidinone antibiotic; phenicol antibiotic |
antibiotic target alteration |
Cfr 23S ribosomal RNA methyltransferase |
| Escherichia coli gyrA conferring resistance to fluoroquinolones |
ARO:3003294 |
40,276 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrA |
| IMP-64 |
ARO:3005471 |
1 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| IMP-66 |
ARO:3005473 |
2 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| QepA4 |
ARO:3004379 |
482 |
fluoroquinolone antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| MCR-3.1 |
ARO:3004139 |
75 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| IMP-6 |
ARO:3002197 |
59 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| Escherichia coli rpoB mutants conferring resistance to rifampicin |
ARO:3003288 |
148 |
rifamycin antibiotic |
antibiotic target alteration; antibiotic target replacement |
rifamycin-resistant beta-subunit of RNA polymerase (rpoB) |
| IMP-8 |
ARO:3002199 |
2 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| IMP-4 |
ARO:3002195 |
61 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| MOX-9 |
ARO:3002191 |
4 |
cephalosporin; cephamycin; penam |
antibiotic inactivation |
MOX beta-lactamase |
| IMP-1 |
ARO:3002192 |
50 |
carbapenem; cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
IMP beta-lactamase |
| CMY-150 |
ARO:3005016 |
1 |
cephamycin |
antibiotic inactivation |
CMY beta-lactamase |
| qacEdelta1 |
ARO:3005010 |
30,740 |
disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| qacE |
ARO:3005009 |
56 |
disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam |
ARO:3007421 |
9 |
cephalosporin; cephamycin; penam |
antibiotic target alteration |
Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics |
| NDM-40 |
ARO:3007217 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| NDM-41 |
ARO:3007218 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| BLMT |
ARO:3005036 |
2 |
glycopeptide antibiotic |
antibiotic inactivation |
Bleomycin resistant protein |
| NDM-39 |
ARO:3007216 |
8 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| NDM-36 |
ARO:3007213 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| NDM-37 |
ARO:3007214 |
2 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-244 |
ARO:3007453 |
842 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-243 |
ARO:3005273 |
102 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-245 |
ARO:3007454 |
119 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| NDM-35 |
ARO:3007212 |
1 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-247 |
ARO:3007451 |
196 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-240 |
ARO:3005270 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-242 |
ARO:3005272 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| mgrA |
ARO:3000815 |
6 |
fluoroquinolone antibiotic; cephalosporin; penam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-44 |
ARO:3001906 |
8 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| MexT |
ARO:3000814 |
1 |
fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexS |
ARO:3000813 |
1 |
fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-39 |
ARO:3001901 |
11 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| nalC |
ARO:3000818 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-38 |
ARO:3001900 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-236 |
ARO:3005267 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| OXA-932 |
ARO:3006115 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| FosL1 |
ARO:3005024 |
23 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| TEM-238 |
ARO:3005269 |
23 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| NDM-16b |
ARO:3007202 |
4 |
carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| TEM-237 |
ARO:3005268 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-232 |
ARO:3005263 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-231 |
ARO:3005262 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-234 |
ARO:3005265 |
18 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-229 |
ARO:3005260 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MexF |
ARO:3000804 |
1 |
fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexE |
ARO:3000803 |
1 |
fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| OprJ |
ARO:3000802 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexD |
ARO:3000801 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexI |
ARO:3000808 |
1 |
fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexH |
ARO:3000807 |
1 |
fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| MexG |
ARO:3000806 |
1 |
fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-71 |
ARO:3001932 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| LptD |
ARO:3005059 |
4 |
peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic |
antibiotic efflux |
ATP-binding cassette (ABC) antibiotic efflux pump |
| MCR-1.18 |
ARO:3007233 |
13 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| ArnT |
ARO:3005053 |
153,879 |
peptide antibiotic |
antibiotic target alteration |
pmr phosphoethanolamine transferase |
| MCR-4.6 |
ARO:3007231 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-1.27 |
ARO:3007232 |
2 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| CTX-M-67 |
ARO:3001928 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-62 |
ARO:3001923 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-64 |
ARO:3001925 |
157 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-65 |
ARO:3001926 |
1,096 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| arlR |
ARO:3000838 |
1 |
fluoroquinolone antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| CTX-M-61 |
ARO:3001922 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| evgS |
ARO:3000833 |
147,444 |
macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| evgA |
ARO:3000832 |
151,636 |
macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump |
| cpxA |
ARO:3000830 |
153,770 |
aminoglycoside antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| eptB |
ARO:3005047 |
10 |
peptide antibiotic |
antibiotic target alteration |
pmr phosphoethanolamine transferase |
| CrcB |
ARO:3005049 |
1 |
aminoglycoside antibiotic |
antibiotic efflux |
multidrug and toxic compound extrusion (MATE) transporter |
| cmlA9 |
ARO:3005043 |
14 |
phenicol antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| OmpA |
ARO:3005044 |
1 |
peptide antibiotic |
reduced permeability to antibiotic |
General Bacterial Porin with reduced permeability to peptide antibiotics |
| MCR-1.2 |
ARO:3004194 |
22 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| YajC |
ARO:3005040 |
1 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; oxazolidinone antibiotic; glycopeptide antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-55 |
ARO:3001917 |
3,865 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-58 |
ARO:3001919 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| ramA |
ARO:3000823 |
11 |
fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux; reduced permeability to antibiotic |
resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams |
| baeS |
ARO:3000829 |
153,651 |
aminoglycoside antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| baeR |
ARO:3000828 |
153,880 |
aminoglycoside antibiotic; aminocoumarin antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| CTX-M-52 |
ARO:3001914 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| rmtC |
ARO:3000861 |
28 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| rmtB |
ARO:3000860 |
1,848 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| QnrVC4 |
ARO:3002801 |
26 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| CTX-M-90 |
ARO:3001950 |
10 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| PC1 beta-lactamase (blaZ) |
ARO:3000621 |
6 |
penam |
antibiotic inactivation |
BlaZ beta-lactamase |
| qacG |
ARO:3007015 |
483 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| sdrM |
ARO:3007013 |
6 |
fluoroquinolone antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| qacJ |
ARO:3007014 |
1,716 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| sepA |
ARO:3007012 |
4 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| norC |
ARO:3007010 |
2 |
fluoroquinolone antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| OXA-72 |
ARO:3001705 |
2 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| armA |
ARO:3000858 |
252 |
aminoglycoside antibiotic |
antibiotic target alteration |
16S rRNA methyltransferase (G1405) |
| CTX-M-88 |
ARO:3001948 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-82 |
ARO:3001943 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-79 |
ARO:3001940 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| rsmA |
ARO:3005069 |
154,086 |
fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| ParR |
ARO:3005068 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux; reduced permeability to antibiotic |
resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr) |
| cprS |
ARO:3005064 |
1 |
peptide antibiotic |
antibiotic target alteration; antibiotic efflux |
pmr phosphoethanolamine transferase |
| ParS |
ARO:3005067 |
1 |
macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics |
antibiotic efflux; reduced permeability to antibiotic |
resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr) |
| cprR |
ARO:3005063 |
1 |
peptide antibiotic |
antibiotic target alteration; antibiotic efflux |
pmr phosphoethanolamine transferase |
| CTX-M-73 |
ARO:3001934 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-75 |
ARO:3001936 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-12 |
ARO:3000884 |
30 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-115 |
ARO:3001975 |
18 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-10 |
ARO:3000882 |
10 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-9 |
ARO:3000881 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-17 |
ARO:3000888 |
3 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-15 |
ARO:3000886 |
4 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-112 |
ARO:3001972 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| qacL |
ARO:3005098 |
5,899 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| TEM-8 |
ARO:3000880 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MCR-3.19 |
ARO:3007273 |
2 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-3.39 |
ARO:3007271 |
14 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| TEM-6 |
ARO:3000878 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-104 |
ARO:3001963 |
24 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-1 |
ARO:3000873 |
37,544 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| Escherichia coli cyaA with mutation conferring resistance to fosfomycin |
ARO:3003900 |
17,563 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant cya adenylate cyclase |
| TEM-5 |
ARO:3000877 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-101 |
ARO:3001960 |
30 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-4 |
ARO:3000876 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-102 |
ARO:3001961 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-3 |
ARO:3000875 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-2 |
ARO:3000874 |
9 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MCR-3.20 |
ARO:3007266 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| NDM-33 |
ARO:3007023 |
1 |
fluoroquinolone antibiotic; carbapenem; cephalosporin; cephamycin; penam |
antibiotic inactivation |
NDM beta-lactamase |
| MCR-3.24 |
ARO:3007265 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-3.21 |
ARO:3007262 |
3 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| AAC(3)-IIg |
ARO:3005085 |
63 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(3) |
| QnrVC6 |
ARO:3002803 |
5 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| FosA2 |
ARO:3002804 |
37 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| CTX-M-98 |
ARO:3001957 |
7 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-99 |
ARO:3001958 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-138 |
ARO:3001996 |
3 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| aadA2 |
ARO:3002602 |
11,322 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| CTX-M-139 |
ARO:3001997 |
1 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| aadA3 |
ARO:3002603 |
639 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| aadA4 |
ARO:3002604 |
34 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(3'') |
| CTX-M-134 |
ARO:3001992 |
11 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-137 |
ARO:3001994 |
10 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-136 |
ARO:3001995 |
2 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-132 |
ARO:3001991 |
64 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-130 |
ARO:3001989 |
14 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| Salmonella enterica gyrA conferring resistance to fluoroquinolones |
ARO:3003926 |
1 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrA |
| lnuC |
ARO:3002837 |
21 |
lincosamide antibiotic |
antibiotic inactivation |
lincosamide nucleotidyltransferase (LNU) |
| lnuF |
ARO:3002839 |
25 |
lincosamide antibiotic |
antibiotic inactivation |
lincosamide nucleotidyltransferase (LNU) |
| oqxA |
ARO:3003922 |
2,067 |
fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| sul1 |
ARO:3000410 |
30,726 |
sulfonamide antibiotic |
antibiotic target replacement |
sulfonamide resistant sul |
| CTX-M-127 |
ARO:3001986 |
8 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| oqxB |
ARO:3003923 |
2,052 |
fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| lnuA |
ARO:3002835 |
45 |
lincosamide antibiotic |
antibiotic inactivation |
lincosamide nucleotidyltransferase (LNU) |
| TEM-29 |
ARO:3000899 |
6 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-122 |
ARO:3001981 |
4 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| CTX-M-123 |
ARO:3001982 |
98 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| AcrS |
ARO:3000656 |
146,773 |
fluoroquinolone antibiotic; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics |
antibiotic efflux |
resistance-nodulation-cell division (RND) antibiotic efflux pump |
| TEM-28 |
ARO:3000898 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| sul3 |
ARO:3000413 |
6,733 |
sulfonamide antibiotic |
antibiotic target replacement |
sulfonamide resistant sul |
| vgaALC |
ARO:3002830 |
1 |
lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic |
antibiotic target protection |
vga-type ABC-F protein |
| sul2 |
ARO:3000412 |
41,711 |
sulfonamide antibiotic |
antibiotic target replacement |
sulfonamide resistant sul |
| CTX-M-125 |
ARO:3001984 |
24 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-26 |
ARO:3000896 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| CTX-M-121 |
ARO:3001980 |
11 |
cephalosporin |
antibiotic inactivation |
CTX-M beta-lactamase |
| TEM-20 |
ARO:3000891 |
10 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| TEM-19 |
ARO:3000890 |
34 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| MCR-1.32 |
ARO:3007289 |
7 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-2.3 |
ARO:3007284 |
6 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| MCR-5.3 |
ARO:3007282 |
1 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| Erm(52) |
ARO:3007041 |
1 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| MCR-1.26 |
ARO:3007280 |
60 |
peptide antibiotic |
antibiotic target alteration |
MCR phosphoethanolamine transferase |
| EreA2 |
ARO:3002826 |
116 |
macrolide antibiotic |
antibiotic inactivation |
macrolide esterase |