Staphylococcus aureus

金黄色葡萄球菌
Virulence Factors: Temporal Map
VFs in isolation sources
List
Virulence factor Related gene Frequency Genomes statistics VF ID VF function Description
Alpha-hemolysin hly/hla 1.058673 43,566 VF0001 Exotoxin (hly/hla) Alpha-Hemolysin precursor [Alpha-hemolysin (VF0001) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
IcsP (SopA) icsP/sopA 0.0000457 2 VF0122 Exoenzyme (icsP/sopA) outer membrane protease of the OmpP family, involved in cleavage of surface exposed IcsA [IcsP (SopA) (VF0122) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301]
FBPs fbaA 0.0000685 3 VF0243 Adherence (fbp54) fibronectin-bing protein Fbp54 [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180]
Ata ata 0.0000685 3 VF1333 Adherence (ata) trimeric autotransporter adhesin Ata [Ata (VF1333) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU]
TFP pilW 0.0006397 10 VF1334 Adherence (pilP) pilus assembly protein PilP [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU]
CbetaG cgs 0.0064888 17 VF0366 Immune modulation (cgs) cyclic beta 1-2 glucan synthetase [CbetaG (VF0366) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]
Capsule cap8F 13.7271751 43,768 VF0003 Immune modulation (cap8J) type 8 capsular polysaccharide synthesis protein Cap8J [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]
LPS gtrA 0.000457 15 VF0124 Immune modulation (gtrA) bactoprenol-linked glucose translocase/flippase [LPS (VF0124) - Immune modulation (VFC0258)] [Shigella flexneri 2a str. 301]
Beta-hemolysin hlb 1.7873561 43,743 VF0002 Exotoxin (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL]
Hyaluronic acid capsule hasC 0.0020334 87 VF0244 Immune modulation (hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS]
VirB type IV secretion system virB4 0.0000228 1 VF0365 Effector delivery system (virB4) type IV secretion system protein ATPase VirB4 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M]
BvrR-BvrS bvrR 0.0020563 17 VF0368 Regulation (bvrR) response regulator transcription factor [BvrR-BvrS (VF0368) - Regulation (VFC0301)] [Brucella melitensis bv. 1 str. 16M]
T6SS vgrG/tssI 0.0003199 9 VF1337 Effector delivery system (tssF) type VI secretion system baseplate subunit TssF [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU]
CNA cna 0.6637041 15,669 VF0005 Adherence (cna) collagen adhesin precursor [CNA (VF0005) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
TlyC tlyC 0.0000685 3 VF0489 Exoenzyme (tlyC) hemolysin C [TlyC (VF0489) - Exoenzyme (VFC0251)] [Rickettsia typhi str. Wilmington]
Clumping factor clfA 0.940733 25,533 VF0004 Adherence (clfB) Clumping factor B, adhesin [Clumping factor (VF0004) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
LPS lpxD 1.016199 43,749 VF0367 Immune modulation (manCcore) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]
Delta-hemolysin hld 0.9691099 42,393 VF0007 Exotoxin (hld) delta-hemolysin [Delta-hemolysin (VF0007) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
T2SS gspD 0.0001599 5 VF1335 Effector delivery system (gspE1) general secretion pathway protein E [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU]
CT ctxB 0.0000228 1 VF0128 Exotoxin (ctxB) cholera enterotoxin, B subunit [CT (VF0128) - Exotoxin (VFC0235)] [Vibrio cholerae O1 biovar El Tor str. N16961]
Staphopain sspB 2.0131603 43,755 VF0006 Exoenzyme (sspB) staphopain cysteine proteinase SspB [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
VirB/VirD4 type IV secretion system virB3 0.0048437 17 VF0369 Effector delivery system (virB2) type IV secretion system major pilin subunit VirB2 protein homolog [VirB/VirD4 type IV secretion system (VF0369) - Effector delivery system (VFC0086)] [Bartonella henselae str. Houston-1]
ACF acfD 0.0000228 1 VF0127 Others (acfD) accessory colonization factor AcfD [ACF (VF0127) - Others (VFC0346)] [Vibrio cholerae O1 biovar El Tor str. N16961]
Exfoliative toxin etb 0.0261607 1,021 VF0009 Exoenzyme (etb) exfoliative toxin B [Exfoliative toxin (VF0009) - Exoenzyme (VFC0251)] [Staphylococcus aureus]
EbpS ebp 0.9747304 42,433 VF0008 Adherence (ebp) cell surface elastin binding protein [EbpS (VF0008) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
BmaA bmaA 0.0007768 14 VF1339 Adherence (bmaA) autotransporter outer membrane beta-barrel domain-containing protein [BmaA (VF1339) - Adherence (VFC0001)] [Brucella suis 1330]
Sulfolipid-1 biosynthesis and transport papA2 0.0000457 2 VF0803 Immune modulation (papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]
T6SS clpB 0.0001828 7 VF0480 Effector delivery system (hcp1) HcpA-like protein [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
BopD bopD 0.0002056 8 VF0362 Biofilm (bopD) sugar-binding transcriptional regulator, LacI family [BopD (VF0362) - Biofilm (VFC0271)] [Enterococcus faecalis V583]
TraJ AAA92657 0.0000228 1 VF0241 Invasion (AAA92657) unknown protein [TraJ (VF0241) - Invasion (VFC0083)] [Escherichia coli]
Capsule cpsC 0.0019878 62 VF0361 Immune modulation (cpsB/cdsA) phosphatidate cytidylyltransferase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583]
RtxA rtxB 0.0001142 5 VF0482 Exotoxin (rtxE) RTX toxin transporter, ATPase protein [RtxA (VF0482) - Exotoxin (VFC0235)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
FbpA/Fbp68 fbpA/fbp68 0.0000457 2 VF0595 Adherence (fbpA/fbp68) fibronectin-binding protein FbpA [FbpA/Fbp68 (VF0595) - Adherence (VFC0001)] [Clostridium difficile 630]
PhoPQ phoP 0.0001371 6 VF0111 Regulation (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Lateral flagella lfgG 0.0000685 2 VF0474 Motility (lfgG) lateral flagellar basal-body rod protein LfgG [Lateral flagella (VF0474) - Motility (VFC0204)] [Aeromonas salmonicida subsp. salmonicida A449]
Esp esp 0.0000228 1 VF0353 Adherence (esp) Enterococcal surface protein; Esp [Esp (VF0353) - Adherence (VFC0001)] [Enterococcus faecalis str. MMH594]
GroEL groEL 1.0060775 43,758 VF0594 Adherence (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630]
Polar flagella nueA 0.0015308 51 VF0473 Motility (flrA) FleQ protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119]
Sat sat 0.0000228 1 VF0231 Effector delivery system (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073]
AS prgB/asc10 0.0001371 3 VF0352 Adherence (EF0485) aggregation substance [AS (VF0352) - Adherence (VFC0001)] [Enterococcus faecalis V583]
Chu chuW 0.0000914 3 VF0234 Nutritional/Metabolic factor (chuU) heme permease protein ChuU [Chu (VF0234) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli O157:H7 str. EDL933]
Fur fur 0.0000228 1 VF0113 Regulation (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Flp type IV pili flpF 0.0000228 1 VF0476 Adherence (flpF) traffic ATPase [Flp type IV pili (VF0476) - Adherence (VFC0001)] [Aeromonas hydrophila ML09-119]
EfaA efaA 0.0000685 3 VF0354 Adherence (efaA) endocarditis specific antigen [EfaA (VF0354) - Adherence (VFC0001)] [Enterococcus faecalis V583]
RpoS rpoS 0.0000457 2 VF0112 Regulation (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Tsh tsh 0.0000228 1 VF0233 Effector delivery system (tsh) temperature-sensitive protein Tsh [Tsh (VF0233) - Effector delivery system (VFC0086)] [Escherichia coli O25b:H4-ST131]
OmpA ompA 0.0000457 2 VF0236 Invasion (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218]
Exe T2SS exeD 0.0000228 1 VF0478 Effector delivery system (exeD) general secretion pathway protein D [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119]
Flagella eptC 0.0000914 4 VF0114 Motility (ptmA) flagellin modification protein A [Flagella (VF0114) - Motility (VFC0204)] [Campylobacter jejuni subsp. jejuni NCTC 11168]
Cytolysin cylB 0.0001599 2 VF0356 Exotoxin (cylM) CylM; cytolysin subunit modifier [Cytolysin (VF0356) - Exotoxin (VFC0235)] [Enterococcus faecalis str. MMH594]
Hyaluronidase EF0818 0.0000457 1 VF0359 Exoenzyme (EF0818) polysaccharide lyase, family 8 [Hyaluronidase (VF0359) - Exoenzyme (VFC0251)] [Enterococcus faecalis V583]
TTSS (SPI-1 encode) invA 0.0003884 8 VF0116 Effector delivery system (spaS) type III secretion system export apparatus switch protein SpaS [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
SprE sprE 0.0000228 1 VF0358 Exoenzyme (sprE) serine proteinase, V8 family [SprE (VF0358) - Exoenzyme (VFC0251)] [Enterococcus faecalis V583]
Ibes ibeC 0.0000914 4 VF0237 Invasion (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88]
T3SS ascV 0.0000228 1 VF0479 Effector delivery system (ascV) Type III secretion system inner membrane export apparatus protein AscV [T3SS (VF0479) - Effector delivery system (VFC0086)] [Aeromonas salmonicida subsp. salmonicida A449]
TTSS mxiA 0.0000457 2 VF0118 Effector delivery system (virB) transcriptional activator VirB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301]
K1 capsule kpsT 0.0001599 3 VF0239 Invasion (kpsC) Capsule polysaccharide export protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88]
Phospholipase C plc1 0.0000228 1 VF0470 Exotoxin (plc1) phospholipase C [Phospholipase C (VF0470) - Exotoxin (VFC0235)] [Acinetobacter baumannii ACICU]
PNAG pgaB 0.0000228 1 VF0472 Biofilm (pgaB) poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB [PNAG (VF0472) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU]
Salmochelin siderophore iroN 0.0001599 6 VF0230 Nutritional/Metabolic factor (iroN) salmochelin receptor IroN [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073]
CD0873 CD0873 0.0000228 1 VF0593 Adherence (CD0873) ABC transporter substrate-binding protein [CD0873 (VF0593) - Adherence (VFC0001)] [Clostridium difficile 630]
BSH bsh 0.0000457 2 VF0350 Stress survival (bsh) bile salt hydrolase [BSH (VF0350) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e]
V8 protease sspA 1.004958 43,596 VF0023 Exoenzyme (sspA) serine protease; V8 protease; glutamyl endopeptidase [V8 protease (VF0023) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
Capsule cps4D 0.0013252 27 VF0144 Immune modulation (cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]
MARTX rtxB 0.0001599 5 VF0265 Exotoxin (rtxA) RTX toxin RtxA [MARTX (VF0265) - Exotoxin (VFC0235)] [Vibrio cholerae O1 biovar El Tor str. N16961]
PmrAB pmrA 0.0000914 4 VF1355 Regulation (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Hpt hpt 0.0002285 8 VF0264 Nutritional/Metabolic factor (hpt) hexose phosphate transport protein [Hpt (VF0264) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e]
TSST-1 tsst-1 0.0947953 4,089 VF0022 Exotoxin (tsst-1) toxic shock syndrome toxin-1 [TSST-1 (VF0022) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus N315]
Autolysin lytA 0.0000685 3 VF0143 Exoenzyme (cbpD) choline binding protein D [Autolysin (VF0143) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4]
TTSS secreted effectors espY4 0.0000228 1 VF1111 Effector delivery system (espY4) Type III secretion system effector EspY4 [TTSS secreted effectors (VF1111) - Effector delivery system (VFC0086)] [Escherichia coli O55:H7 str. CB9615]
Tbp tbpA 0.0000228 1 VF0267 Nutritional/Metabolic factor (tbpA) transferrin-binding protein 1 precursor [Tbp (VF0267) - Nutritional/Metabolic factor (VFC0272)] [Haemophilus influenzae Rd KW20]
Hyaluronidase hysA 0.0000457 2 VF0146 Exoenzyme (hysA) hyaluronidase [Hyaluronidase (VF0146) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4]
Aureolysin aur 1.0209742 43,750 VF0024 Exoenzyme (aur) zinc metalloproteinase aureolysin [Aureolysin (VF0024) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
Vat vat 0.0000228 1 VF1112 Effector delivery system (vat) vacuolating autotransporter toxin [Vat (VF1112) - Effector delivery system (VFC0086)] [Escherichia coli CFT073]
CBPs pce/cbpE 0.0000228 1 VF0145 Adherence (pce/cbpE) choline binding protein E [CBPs (VF0145) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4]
HxuABC hxuB 0.0000228 1 VF0269 Nutritional/Metabolic factor (hxuB) heme-hemopexin utilization protein B HxuB, two-partner secretion (TPS) pathway TpsB outer membrane pore-forming translocator protein [HxuABC (VF0269) - Nutritional/Metabolic factor (VFC0272)] [Haemophilus influenzae Rd KW20]
HitABC hitC 0.0010738 10 VF0268 Nutritional/Metabolic factor (hitC) iron(III) ABC transporter, ATP-binding protein [HitABC (VF0268) - Nutritional/Metabolic factor (VFC0272)] [Haemophilus influenzae Rd KW20]
IgA1 protease iga 0.0000228 1 VF0147 Immune modulation (iga) G5 domain-containing protein [IgA1 protease (VF0147) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]
Mu-toxin nagJ 0.0000457 1 VF0389 Exoenzyme (nagJ) hyaluronidase [Mu-toxin (VF0389) - Exoenzyme (VFC0251)] [Clostridium perfringens str. 13]
Cya cyaD 0.0003884 8 VF0028 Exotoxin (cyaD) cyclolysin secretion protein [Cya (VF0028) - Exotoxin (VFC0235)] [Bordetella pertussis Tohama I]
Pneumolysin ply 0.0000228 1 VF0149 Exotoxin (ply) pneumolysin [Pneumolysin (VF0149) - Exotoxin (VFC0235)] [Streptococcus pneumoniae TIGR4]
HSI-3 PA2359 0.0000228 1 VF0944 Effector delivery system (PA2359) transcriptional regulator [HSI-3 (VF0944) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1]
HSI-2 tssH 0.0000685 2 VF0943 Effector delivery system (PA1663) transcriptional regulator [HSI-2 (VF0943) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1]
TTSS effectors secreted via both systems slrP 0.0000914 4 VF0948 Effector delivery system (steA) type III secretion system effector SteA (Salmonella translocated effector A) [TTSS effectors secreted via both systems (VF0948) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
TTSS-2 secreted effectors sspH2 0.0002285 7 VF0947 Effector delivery system (sseL) type III secretion system effector SseL, deubiquitinase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
TTSS-1 secreted effectors sopB/sigD 0.0002056 6 VF0949 Effector delivery system (sopD) type III secretion system effector SopD [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
CsrA csrA 0.0000457 2 VF0261 Regulation (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
TTSS secreted effectors espL1 0.0001371 6 VF1110 Effector delivery system (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933]
RelA relA 0.0000457 2 VF0260 Regulation (relA) GTP diphosphokinase [RelA (VF0260) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
Staphylokinase sak 0.7836547 34,039 VF0021 Exoenzyme (sak) Staphylokinase precursor [Staphylokinase (VF0021) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
Capsule capB 0.0001828 6 VF0141 Immune modulation (capB) CapB, involved in Poly-gamma-glutamate synthesis [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis]
LetA/S letA 0.0000228 1 VF0262 Regulation (letA) UvrY/SirA/GacA family response regulator transcription factor [LetA/S (VF0262) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
SE sec 2.2112045 33,152 VF0020 Exotoxin (seh) staphylococcal enterotoxin H precursor [SE (VF0020) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
Lipase lip 2.0633568 43,764 VF0012 Exoenzyme (lip) triacylglycerol lipase precursor [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
Isocitrate lyase icl 0.0010053 18 VF0253 Others (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]
Gamma-hemolysin hlgC 3.7580196 43,764 VF0011 Exotoxin (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
Intercellular adhesion proteins icaR 5.1109715 43,713 VF0014 Biofilm (icaR) ica operon transcriptional regulator IcaR [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2]
BtaE btaE 0.0002742 10 VF1342 Adherence (btaE) Trimeric autotransporter adhesin, YadA-like family protein [BtaE (VF1342) - Adherence (VFC0001)] [Brucella melitensis biovar Abortus 2308]
Shu shuV 0.0001142 4 VF0256 Nutritional/Metabolic factor (shuV) ATP-binding component of hemin transport system [Shu (VF0256) - Nutritional/Metabolic factor (VFC0272)] [Shigella dysenteriae Sd197]
TcdB toxB 0.0000228 1 VF0377 Exotoxin (toxB) toxin B [TcdB (VF0377) - Exotoxin (VFC0235)] [Clostridium difficile 630]
Hyaluronate lyase hysA 1.3490678 43,726 VF0013 Exoenzyme (hysA) hyaluronate lyase precursor [Hyaluronate lyase (VF0013) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
Eap/Map eap/map 1.0544005 43,166 VF0016 Adherence (eap/map) extracellular adherence protein Eap/Map [Eap/Map (VF0016) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
Ymt ymt 0.0000228 1 VF0137 Exotoxin (ymt) murine toxin [Ymt (VF0137) - Exotoxin (VFC0235)] [Yersinia pestis CO92]
SigA sigA/rpoV 1.0008682 43,739 VF0257 Regulation (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]
Yersiniabactin ybtE 0.0005483 11 VF0136 Nutritional/Metabolic factor (irp1) yersiniabactin biosynthetic protein Irp1 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92]
Isd isdA 10.1145586 43,765 VF0015 Nutritional/Metabolic factor (harA) haptoglobin-binding heme uptake protein HarA [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman]
PVL lukS-PV 1.146454 32,328 VF0018 Exotoxin (lukS-PV) Panton-Valentine leukocidin chain S precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
SpA spa 1.369151 43,454 VF0017 Exotoxin (spa) Immunoglobulin G binding protein A precursor [SpA (VF0017) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
SDr sdrE 3.119905 43,438 VF0019 Adherence (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
BmaB/OmaA bmaB/omaA 0.0003884 9 VF1340 Adherence (bmaB/omaA) autotransporter outer membrane beta-barrel domain-containing protein [BmaB/OmaA (VF1340) - Adherence (VFC0001)] [Brucella melitensis bv. 1 str. 16M]
BadA/Vomp badA/vomp/brp 0.0000457 2 VF0371 Adherence (badA/vomp/brp) Surface protein/Bartonella adhesin BadA/VompA/VompC/VompD [BadA/Vomp (VF0371) - Adherence (VFC0001)] [Bartonella henselae str. Houston-1]
LPS kdsA 0.0004113 10 VF0370 Immune modulation (lpxB) lipid-A-disaccharide synthase [LPS (VF0370) - Immune modulation (VFC0258)] [Bartonella henselae str. Houston-1]
BmaC bmaC 0.0007768 10 VF1341 Adherence (bmaC) autotransporter outer membrane beta-barrel domain-containing protein [BmaC (VF1341) - Adherence (VFC0001)] [Brucella suis 1330]
Flagella motB 0.0084765 17 VF0373 Motility (motA) lateral flagellar motor protein MotA [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583]
FnBPs fnbA 2.2341894 43,717 VF0010 Adherence (fnbA) fibronectin-binding protein A [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2]
Ent entF 0.0008682 14 VF0562 Nutritional/Metabolic factor (fepD) iron-enterobactin transporter membrane protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
OatA oatA 0.0002742 10 VF0441 Immune modulation (oatA) peptidoglycan O-acetyltransferase [OatA (VF0441) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e]
LntA lntA 0.0000457 2 VF0440 Immune modulation (lntA) listeria nuclear targeted protein A [LntA (VF0440) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e]
LPS rfbB 0.0000457 2 VF0561 Immune modulation (rfbB) O-antigen export ABC transporter ATP-binding protein RfbB [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
Ybt ybtS 0.0001599 6 VF0564 Nutritional/Metabolic factor (fyuA) yersiniabactin receptor FyuA [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
Sal iroN 0.0001371 5 VF0563 Nutritional/Metabolic factor (iroN) salmochelin receptor IroN [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
TTSS (SPI-2 encode) ssaE 0.0001599 5 VF0321 Effector delivery system (ssaE) chaperone for sseB [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
PgdA pdgA 0.0000457 2 VF0442 Immune modulation (pdgA) Peptidoglycan N-deacetylase [PgdA (VF0442) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e]
Type I fimbriae fimE 0.0001828 7 VF0566 Adherence (fimC) periplasmic chaperone [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
Capsule glf 0.0001599 7 VF0323 Immune modulation (kfiD) UDP-glucose 6-dehydrogenase [Capsule (VF0323) - Immune modulation (VFC0258)] [Campylobacter jejuni subsp. jejuni NCTC 11168]
Lap lap 1.0007083 43,175 VF0444 Adherence (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e]
AcrAB acrA 0.0013252 42 VF0568 Antimicrobial activity/Competitive advantage (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
InlF inlF 0.0000228 1 VF0447 Adherence (inlF) internalin F [InlF (VF0447) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e]
Type 3 fimbriae mrkH 0.0000457 2 VF0567 Biofilm (mrkC) fimbrial biogenesis outer membrane usher protein mrkC precursor [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
LapB lapB 0.0000228 1 VF0446 Adherence (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e]
Hemolysin hlyB 0.0001828 7 VF0207 Exotoxin (hlyB) Hemolysin B [Hemolysin (VF0207) - Exotoxin (VFC0235)] [Escherichia coli O157:H7 str. EDL933]
PrsA2 prsA2 0.0000457 2 VF0449 Post-translational modification (prsA2) post translocation chaperone PrsA2 [PrsA2 (VF0449) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e]
T6SS vgrG/tssI 0.0003884 13 VF0569 Effector delivery system (vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
JlpA jlpA 0.0000228 1 VF0329 Adherence (jlpA) lipoprotein [JlpA (VF0329) - Adherence (VFC0001)] [Campylobacter jejuni subsp. jejuni NCTC 11168]
Capsule KP1_RS17345 1.0136401 43,758 VF0560 Immune modulation (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
Flagella tsr 0.0000685 3 VF0430 Motility (tsr) methyl-accepting chemotaxis protein I [Flagella (VF0430) - Motility (VFC0204)] [Burkholderia pseudomallei K96243]
FupA feoB 0.0001142 5 VF0550 Nutritional/Metabolic factor (feoB) Fe(2+) transporter permease subunit FeoB [FupA (VF0550) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4]
CdpA cdpA 0.0000914 3 VF0432 Regulation (cdpA) cyclic di-GMP phosphodiesterase [CdpA (VF0432) - Regulation (VFC0301)] [Burkholderia pseudomallei K96243]
GGT ggt 0.0002742 10 VF0553 Nutritional/Metabolic factor (ggt) gamma-glutamyltranspeptidase [GGT (VF0553) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4]
Biotin synthesis bioB 0.0001142 5 VF0552 Nutritional/Metabolic factor (bioB) biotin synthase [Biotin synthesis (VF0552) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4]
Quorum-sensing pmlR/bspR1 0.0000228 1 VF0433 Biofilm (pmlR/bspR1) N-acylhomoserine lactone dependent regulatory protein [Quorum-sensing (VF0433) - Biofilm (VFC0271)] [Burkholderia pseudomallei K96243]
Capsule I wzt2 0.0001599 7 VF0436 Immune modulation (wzt2) ATP-binding ABC transporter capsular polysaccharide export protein [Capsule I (VF0436) - Immune modulation (VFC0258)] [Burkholderia pseudomallei K96243]
ESX-1 eccA1 0.0000228 1 VF0315 Effector delivery system (eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]
Dot/Icm T4SS secreted effectors LPG_RS11255 0.0000685 3 VF0798 Effector delivery system (LPG_RS14840) Dot/Icm type IV secretion system effector [Dot/Icm T4SS secreted effectors (VF0798) - Effector delivery system (VFC0086)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
Purine biosynthesis purM 0.0001828 5 VF0559 Nutritional/Metabolic factor (purCD) fusion protein PurC/PurD [Purine biosynthesis (VF0559) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4]
Pyrimidine biosynthesis carB 0.0029702 63 VF0558 Nutritional/Metabolic factor (carA) carbamoyl phosphate synthase small subunit [Pyrimidine biosynthesis (VF0558) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4]
PanC/PanD panC 0.0003427 11 VF0319 Nutritional/Metabolic factor (panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]
InlK inlK 0.0000457 2 VF0439 Immune modulation (inlK) internalin K [InlK (VF0439) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e]
BfmRS bfmS 0.0001828 7 VF0463 Regulation (bfmS) signal transduction histidine kinase [BfmRS (VF0463) - Regulation (VFC0301)] [Acinetobacter baumannii ACICU]
Type 1 fimbriae fimH 0.000297 6 VF0221 Adherence (fimF) FimF protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073]
Petrobactin asbB 0.0000228 1 VF0584 Nutritional/Metabolic factor (asbB) petrobactin biosynthesis protein AsbB [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne]
Cereulide cesC 0.0000914 2 VF0583 Exotoxin (cesC) ABC transporter ATP-binding protein, CesC [Cereulide (VF0583) - Exotoxin (VFC0235)] [Bacillus cereus AH187]
P fimbriae papC 0.0000914 4 VF0220 Adherence (papD) chaperone protein PapD [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073]
Bap bap 0.0000457 2 VF0462 Biofilm (bap) biofilm-associated protein [Bap (VF0462) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU]
Type 1 fimbriae fimH 0.0001599 6 VF0102 Adherence (fimZ) DNA-binding response regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Capsule pseF 0.0010967 28 VF0465 Immune modulation (ACICU_RS00500) phosphomannomutase/phosphoglucomutase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU]
Dr adhesins draC 0.0000457 1 VF0223 Adherence (draC) usher protein DraC [Dr adhesins (VF0223) - Adherence (VFC0001)] [Escherichia coli O75:K5:H- str. IH11128]
Bacillibactin dhbF 0.0000457 2 VF0586 Nutritional/Metabolic factor (dhbF) non-ribosomal peptide synthetase, DhbF [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987]
OmpA ompA 0.0000457 2 VF0464 Immune modulation (ompA) outer membrane protein OmpA [OmpA (VF0464) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU]
Vi antigen tviD 0.0000228 1 VF0101 Immune modulation (tviD) Vi polysaccharide biosynthesis protein TviD [Vi antigen (VF0101) - Immune modulation (VFC0258)] [Salmonella enterica subsp. enterica serovar Typhi str. CT18]
Alpha-Hemolysin hlyA 0.0005483 9 VF0225 Exotoxin (hlyA) Hemolysin A [Alpha-Hemolysin (VF0225) - Exotoxin (VFC0235)] [Escherichia coli CFT073]
Acinetobactin basB 0.0006169 17 VF0467 Nutritional/Metabolic factor (basB) non-ribosomal peptide synthetase with condensation and peptidyl carrier protein domains [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU]
Pef pefB 0.0000228 1 VF0104 Adherence (pefB) plasmid-encoded fimbriae regulatory protein PefB [Pef (VF0104) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
LpeA lpeA 0.0001599 6 VF0346 Invasion (lpeA) lipoprotein promoting cell invasion [LpeA (VF0346) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e]
Agf csgB 0.0000457 2 VF0103 Adherence (csgB) minor curlin subunit precursor, curli nucleator protein CsgB [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
LPS lpxD 0.0002056 6 VF0466 Immune modulation (lpxA) acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU]
F1C fimbriae focC 0.0000228 1 VF0224 Adherence (focC) F1C periplasmic chaperone [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073]
Chu chuX 0.0001142 5 VF0227 Nutritional/Metabolic factor (chuU) heme permease protein ChuU [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073]
MgtB mgtB 0.0000685 3 VF0106 Nutritional/Metabolic factor (mgtB) Mg2+ transport protein [MgtB (VF0106) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
LplA1 lplA1 0.0027189 117 VF0347 Nutritional/Metabolic factor (lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e]
Lpf lpfD 0.0000914 4 VF0105 Adherence (lpfC) long polar fimbrial usher protein LpfC [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Aerobactin iucD 0.0000685 2 VF0229 Nutritional/Metabolic factor (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073]
Rck rck 0.0000228 1 VF0108 Invasion (rck) resistance to complement killing [Rck (VF0108) - Invasion (VFC0083)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Enterobactin entF 0.0012795 29 VF0228 Nutritional/Metabolic factor (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073]
FbpA fbpA 0.0001142 5 VF0349 Adherence (fbpA) fibronectin-binding protein [FbpA (VF0349) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e]
SodCI sodCI 0.0000914 4 VF0109 Stress survival (sodCI) Gifsy-2 prophage: superoxide dismutase precursor (Cu-Zn) [SodCI (VF0109) - Stress survival (VFC0282)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Exolysin exlA 0.0000457 2 VF0582 Effector delivery system (exlA) hemolysin [Exolysin (VF0582) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PA7]
Csu fimbriae csuE 0.0000228 1 VF0461 Biofilm (csuE) Csu pilus tip adhesin CsuE [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU]
EF-Tu tufA 1.0061689 43,764 VF0460 Adherence (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4]
Colibactin clbS 0.0002742 8 VF0573 Exotoxin (clbN) colibactin non-ribosomal peptide synthetase ClbN [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084]
Allantion utilization allB 0.0002742 8 VF0572 Nutritional/Metabolic factor (allB) allantoinase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
MtrCDE mtrD 0.0002056 6 VF0451 Antimicrobial activity/Competitive advantage (mtrD) multiple transferable resistance system protein MtrD [MtrCDE (VF0451) - Antimicrobial activity/Competitive advantage (VFC0325)] [Neisseria meningitidis MC58]
T4SS secreted effectors coxH3 0.0001142 5 VF0696 Effector delivery system (coxH3) Coxiella Dot/Icm type IVB secretion system translocated effector [T4SS secreted effectors (VF0696) - Effector delivery system (VFC0086)] [Coxiella burnetii RSA 493]
KatA katA 1.0139371 43,745 VF0454 Stress survival (katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]
T2SS gspD 0.0000685 2 VF0333 Effector delivery system (gspE) general secretion pathway protein E [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197]
T4SS secreted effectors ricA 0.0095504 18 VF0695 Effector delivery system (bspB) type IV secretion system effector BspB [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M]
MsrAB msrA/B(pilB 0.0003427 14 VF0456 Stress survival (msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]
VAS T6SS vasH 0.0000685 3 VF0335 Effector delivery system (vasH) type VI secretion system regulatory protein VasH [VAS T6SS (VF0335) - Effector delivery system (VFC0086)] [Vibrio cholerae O1 biovar El Tor str. N16961]
AAFs aafC 0.0000228 1 VF0214 Adherence (aafC) aggregative adherence fimbria II usher protein AafC [AAFs (VF0214) - Adherence (VFC0001)] [Escherichia coli O44:H18 042]
MntABC mntC 0.000297 7 VF0455 Stress survival (mntB) Manganese transport system membrane protein MntB [MntABC (VF0455) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]
HSI-1 clpV1 0.0003427 9 VF0334 Effector delivery system (clpV1) type VI secretion system AAA+ family ATPase [HSI-1 (VF0334) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1]
Adhesive fimbriae cfaD/cfaE 0.0000457 2 VF0213 Adherence (cfaD/cfaE) minor pilin and initiator [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A]
T6SS vgrG/tssI 0.0005255 13 VF0579 Effector delivery system (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046]
Type IV pili pilT 0.0000228 1 VF0458 Adherence (pilT) type IV pilus twitching motility protein PilT [Type IV pili (VF0458) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4]
BvgAS bvgS 0.0000457 2 VF0336 Regulation (bvgS) virulence factors two-component system sensor histidine kinase BvgS [BvgAS (VF0336) - Regulation (VFC0301)] [Bordetella pertussis Tohama I]
Dispersin aatC 0.0001599 4 VF0215 Others (aatC) ATP-binding protein AatC [Dispersin (VF0215) - Others (VFC0346)] [Escherichia coli O44:H18 042]
RecN recN 0.0000228 1 VF0457 Stress survival (recN) DNA repair protein RecN [RecN (VF0457) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]
RcsAB rcsB 0.0000685 1 VF0571 Regulation (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
SinH sinH 0.0000685 3 VF0400 Adherence (sinH) intimin-like protein [SinH (VF0400) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ESX-3 eccB3 0.0000228 1 VF0521 Effector delivery system (eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]
Type VII secretion system esaB 16.5570965 43,756 VF0403 Effector delivery system (esaB) type VII secretion system protein EsaB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2]
ECP ykgK/ecpR 0.0001599 5 VF0404 Adherence (ykgK/ecpR) regulator protein EcpR [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933]
AI-2 luxS 0.0000685 3 VF0406 Biofilm (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961]
T3SS1 vscN 0.0000228 1 VF0408 Effector delivery system (vscN) type III secretion system ATPase VscN [T3SS1 (VF0408) - Effector delivery system (VFC0086)] [Vibrio parahaemolyticus RIMD 2210633]
RlrA islet srtC-2/srtC 0.0000457 2 VF0529 Adherence (rrgA) cell wall surface anchor family protein, pilus tip adhesin RrgA [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4]
IgA1 protease iga 0.0000457 2 VF0080 Effector delivery system (iga) IgA-specific serine endopeptidase [IgA1 protease (VF0080) - Effector delivery system (VFC0086)] [Neisseria meningitidis MC58]
Type IV pili fimV 0.0003199 11 VF0082 Adherence (pilR) two-component response regulator PilR [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1]
LPS wbpL 0.0002285 10 VF0085 Immune modulation (wbpM) nucleotide sugar epimerase/dehydratase WbpM [LPS (VF0085) - Immune modulation (VFC0258)] [Pseudomonas aeruginosa PAO1]
SSLs set24 9.9854688 43,723 VF0990 Exotoxin (set19) superantigen-like protein SSL4 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2]
Capsule ctrA 0.0000228 1 VF0079 Immune modulation (ctrA) capsule polysaccharide export outer membrane protein CtrA [Capsule (VF0079) - Immune modulation (VFC0258)] [Neisseria meningitidis MC58]
IlpA IlpA 0.0002513 8 VF0513 Adherence (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016]
MAM7 mam7 0.0000228 1 VF0512 Adherence (mam7) multivalent adhesion molecule MAM7 [MAM7 (VF0512) - Adherence (VFC0001)] [Vibrio parahaemolyticus RIMD 2210633]
HemO cluster ACICU_RS04590 0.0000685 3 VF0636 Nutritional/Metabolic factor (hemO) biliverdin-producing heme oxygenase [HemO cluster (VF0636) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU]
Yst1 T2SS yst1E 0.0000228 1 VF0635 Effector delivery system (yst1E) type II secretion system ATPase GspE [Yst1 T2SS (VF0635) - Effector delivery system (VFC0086)] [Yersinia enterocolitica subsp. enterocolitica 8081]
Flagella fleS/flrB 0.0002742 10 VF0519 Motility (fleN/flhG) MinD-like ATPase [Flagella (VF0519) - Motility (VFC0204)] [Vibrio cholerae O1 biovar El Tor str. N16961]
InlB inlB 0.0000228 1 VF0070 Invasion (inlB) Internalin B [InlB (VF0070) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e]
TTSS cesT 0.0000457 2 VF0191 Effector delivery system (escV) Type III secretion system major export apparatus protein [TTSS (VF0191) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933]
ClpC clpC 1.007951 43,749 VF0072 Stress survival (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e]
Ami ami 0.0000685 3 VF0071 Adherence (ami) autolysin amidase, adhesin [Ami (VF0071) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e]
ClpP clpP 1.0017593 43,762 VF0074 Stress survival (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e]
ClpE clpE 0.0006626 20 VF0073 Stress survival (clpE) ATP-dependent protease [ClpE (VF0073) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e]
Opa opa 0.0000228 1 VF0076 Invasion (opa) outer membrane beta-barrel protein [Opa (VF0076) - Invasion (VFC0083)] [Neisseria meningitidis MC58]
Staphylocoagulase coa 1.0875525 43,681 VF0421 Exoenzyme (coa) staphylocoagulase precursor [Staphylocoagulase (VF0421) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2]
LPS wbtL 0.0012566 31 VF0542 Immune modulation (wbtI) DegT/DnrJ/EryC1/StrS family aminotransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]
VWbp vWbp 1.1007128 43,707 VF0420 Exoenzyme (vWbp) secreted von Willebrand factor-binding protein precursor [VWbp (VF0420) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus str. Newman]
Nitrate reductase narH 0.0063517 201 VF0302 Nutritional/Metabolic factor (narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]
Sbi sbi 1.0147596 43,759 VF0423 Immune modulation (sbi) IgG-binding protein SBI [Sbi (VF0423) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]
AdsA adsA 1.0594727 43,752 VF0422 Immune modulation (adsA) Adenosine synthase A [AdsA (VF0422) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]
Capsule galE 0.0006169 14 VF0543 Immune modulation (galE) UDP-glucose 4-epimerase GalE [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]
SCIN scn 0.8522893 36,906 VF0425 Immune modulation (scn) complement inhibitor SCIN [SCIN (VF0425) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]
CHIPS chp 0.614353 26,639 VF0424 Immune modulation (chp) chemotaxis-inhibiting protein CHIPS [CHIPS (VF0424) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus str. Newman]
KatG katG 0.0000228 1 VF0303 Stress survival (katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]
AhpC ahpC 0.0000914 4 VF0306 Stress survival (ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]
T6SS-1 BPS_RS26875 0.0001371 6 VF0429 Effector delivery system (BPS_RS26875) response regulator VirG [T6SS-1 (VF0429) - Effector delivery system (VFC0086)] [Burkholderia pseudomallei K96243]
Bsa T3SS bsaS 0.0000457 2 VF0428 Effector delivery system (bsaS) ATP synthase [Bsa T3SS (VF0428) - Effector delivery system (VFC0086)] [Burkholderia pseudomallei K96243]
PDIM ddrA 0.0002056 6 VF0309 Immune modulation (Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]
SCI T6SS secreted effectors tae4 0.0000457 1 VF1195 Effector delivery system (tae4) type VI secretion system effector tae4, L,D-endopeptidase [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
LLS llsD 0.0009596 39 VF0410 Exotoxin (llsH) ABC transporter permease protein LlsH [LLS (VF0410) - Exotoxin (VFC0235)] [Listeria innocua SLCC6294]
HBL hblC 0.0000228 1 VF0532 Exotoxin (hblC) Hemolysin BL lytic component L2 [HBL (VF0532) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 14579]
InhA BAS_RS06430 0.0000457 2 VF0536 Exoenzyme (inhA) immune inhibitor A metalloprotease [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne]
Scm scm 0.0000228 1 VF0418 Adherence (scm) collagen adhesin protein Scm [Scm (VF0418) - Adherence (VFC0001)] [Enterococcus faecium DO]
Ebp pili ebpC 0.0000228 1 VF0538 Adherence (ebpC) endocarditis and biofilm-associated pilus major subunit EbpC [Ebp pili (VF0538) - Adherence (VFC0001)] [Enterococcus faecalis V583]
Acm acm 0.0000685 3 VF0419 Adherence (acm) collagen adhesin precursor Acm [Acm (VF0419) - Adherence (VFC0001)] [Enterococcus faecium str. TX2555]
Alginate algU 0.0007997 15 VF0091 Biofilm (algC) phosphomannomutase AlgC [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1]
Pyoverdine pvdD 0.0001371 5 VF0094 Nutritional/Metabolic factor (pvdD) pyoverdine synthetase D [Pyoverdine (VF0094) - Nutritional/Metabolic factor (VFC0272)] [Pseudomonas aeruginosa PAO1]
Pyochelin pchH 0.0001371 5 VF0095 Nutritional/Metabolic factor (pchH) ABC transporter ATP-binding protein [Pyochelin (VF0095) - Nutritional/Metabolic factor (VFC0272)] [Pseudomonas aeruginosa PAO1]
RelA relA 0.0002742 9 VF0287 Regulation (relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]
LOS rffG 0.0023762 44 VF0044 Immune modulation (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20]
KatAB katA 0.0001142 4 VF0168 Stress survival (katA) catalase/(hydro)peroxidase [KatAB (VF0168) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
Lbp lbpA 0.0000228 1 VF0047 Nutritional/Metabolic factor (lbpA) lactoferrin-binding protein A [Lbp (VF0047) - Nutritional/Metabolic factor (VFC0272)] [Neisseria meningitidis MC58]
Tbp tbpA 0.0000228 1 VF0046 Nutritional/Metabolic factor (tbpA) transferrin-binding protein A [Tbp (VF0046) - Nutritional/Metabolic factor (VFC0272)] [Neisseria meningitidis MC58]
SodB sodB 0.0003656 15 VF0169 Stress survival (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
HmbR hmbR 0.0000228 1 VF0048 Nutritional/Metabolic factor (hmbR) hemoglobin receptor [HmbR (VF0048) - Nutritional/Metabolic factor (VFC0272)] [Neisseria meningitidis MC58]
Curli fibers csgA 0.0000914 2 VF1138 Adherence (cgsD) transcriptional regulator CsgD [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131]
PagN pagN 0.0000228 1 VF0968 Invasion (pagN) outer membrane adhesin/invasin protein [PagN (VF0968) - Invasion (VFC0083)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
FeoAB feoB 0.0015993 68 VF0160 Nutritional/Metabolic factor (feoB) ferrous iron transporter B [FeoAB (VF0160) - Nutritional/Metabolic factor (VFC0272)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
Hyaluronidase hylB 0.0000228 1 VF0281 Exoenzyme (hylB) hyaluronidase [Hyaluronidase (VF0281) - Exoenzyme (VFC0251)] [Streptococcus agalactiae NEM316]
P5 protein ompP5 0.0000228 1 VF0041 Adherence (ompP5) outer membrane protein P5 (ompA), human factor H binding protein [P5 protein (VF0041) - Adherence (VFC0001)] [Haemophilus influenzae Rd KW20]
Capsule bexA 0.0000914 3 VF0043 Immune modulation (bcs1') Bcs1' [Capsule (VF0043) - Immune modulation (VFC0258)] [Haemophilus influenzae str. 1007]
Enh loci LPG_RS06765 0.0000457 2 VF0163 Others (LPG_RS06765) saccharopine dehydrogenase NADP-binding domain-containing protein [Enh loci (VF0163) - Others (VFC0346)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
P2 protein ompP2 0.0000228 1 VF0042 Immune modulation (ompP2) outer membrane protein P2 (ompP2), laminin binding protein [P2 protein (VF0042) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20]
MisL misL 0.0000457 2 VF0397 Adherence (misL) putative autotransporter [MisL (VF0397) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Alpha-C protein bca 0.0000228 1 VF0276 Invasion (bca) C protein alpha-antigen [Alpha-C protein (VF0276) - Invasion (VFC0083)] [Streptococcus agalactiae A909]
Type IV pili pilB 0.0000228 1 VF0155 Adherence (pilB) type IV pilus assembly protein PilB [Type IV pili (VF0155) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
LPS bplL 0.0002056 8 VF0033 Immune modulation (bplC) lipopolysaccharide biosynthesis protein [LPS (VF0033) - Immune modulation (VFC0258)] [Bordetella pertussis Tohama I]
Lmb lmb 0.0000228 1 VF0275 Adherence (lmb) laminin-binding surface protein [Lmb (VF0275) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316]
Flagella LPG_RS02380 0.0003199 10 VF0157 Motility (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0157) - Motility (VFC0204)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
RatB ratB 0.0000685 2 VF0399 Adherence (ratB) putative outer membrane protein [RatB (VF0399) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MgtC mgtC 0.0001142 5 VF1365 Nutritional/Metabolic factor (mgtC) Salmonella virulence protein MgtC [MgtC (VF1365) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
TTSS bscN 0.0000914 4 VF0035 Effector delivery system (bscN) ATP synthase in type III secretion system [TTSS (VF0035) - Effector delivery system (VFC0086)] [Bordetella pertussis Tohama I]
ShdA shdA 0.0000457 2 VF0398 Adherence (shdA) AIDA autotransporter-like protein [ShdA (VF0398) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
Hsp60 htpB 0.0010053 32 VF0159 Adherence (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
HMW1/HMW2 hmw2B 0.0000228 1 VF0038 Adherence (hmw2B) two-partner secretion (TPS) pathway TpsB outer membrane pore-forming translocator protein [HMW1/HMW2 (VF0038) - Adherence (VFC0001)] [Haemophilus influenzae str. 12]
Hap hap 0.0000457 2 VF0037 Adherence (hap) adhesion and penetration protein Hap [Hap (VF0037) - Adherence (VFC0001)] [Haemophilus influenzae N187]
Beta-haemolysin/cytolysin cylG 0.0000685 3 VF0279 Exotoxin (cylG) 3-ketoacyl-ACP-reductase CylG [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316]
Hgp hgpC 0.0000457 2 VF0270 Nutritional/Metabolic factor (hgpC) hemoglobin-binding protein [Hgp (VF0270) - Nutritional/Metabolic factor (VFC0272)] [Haemophilus influenzae Rd KW20]
FbpABC fbpC 0.0010967 11 VF0272 Nutritional/Metabolic factor (fbpC) iron(III) ABC transporter, ATP-binding protein [FbpABC (VF0272) - Nutritional/Metabolic factor (VFC0272)] [Neisseria meningitidis MC58]
PsaA psaA 0.0000914 4 VF0151 Nutritional/Metabolic factor (psaA) manganese ABC transporter, manganese-binding adhesion liprotein [PsaA (VF0151) - Nutritional/Metabolic factor (VFC0272)] [Streptococcus pneumoniae TIGR4]
O-antigen galE 0.0002513 10 VF0392 Immune modulation (YE_RS15420) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081]
Capsule GBS_RS06590 0.0000914 4 VF0274 Immune modulation (GBS_RS06590) sugar transferase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316]
Flagella motB 0.0010281 23 VF0394 Motility (fliL) flagellar basal body protein FliL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081]
Flagella motB 0.0003199 8 VF0273 Motility (motB) flagellar motor protein [Flagella (VF0273) - Motility (VFC0204)] [Pseudomonas aeruginosa PAO1]
InlA inlA 0.0000228 1 VF0069 Invasion (inlA) Internalin A [InlA (VF0069) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e]
P60 iap/cwhA 0.0000228 1 VF0068 Invasion (iap/cwhA) P60 extracellular protein, invasion associated protein Iap [P60 (VF0068) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e]
AdeFGH efflux pump adeG 0.0027874 21 VF0504 Biofilm (adeG) cation/multidrug efflux pump [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU]
FdeC fdeC 0.0002285 7 VF0506 Adherence (fdeC) adhesin FdeC [FdeC (VF0506) - Adherence (VFC0001)] [Escherichia coli O45:K1:H7 str. S88]
YapK yapK 0.0000457 2 VF0508 Adherence (yapK) autotransporter protein YapK [YapK (VF0508) - Adherence (VFC0001)] [Yersinia pestis CO92]
YapV yapV 0.0000685 3 VF0507 Adherence (yapV) autotransporter protein YapV [YapV (VF0507) - Adherence (VFC0001)] [Yersinia pestis KIM 10]
YapJ yapJ 0.0000228 1 VF0509 Adherence (yapJ) autotransporter protein YapJ [YapJ (VF0509) - Adherence (VFC0001)] [Yersinia pestis CO92]
Mpl mpl 0.0000228 1 VF0065 Exoenzyme (mpl) Zinc metalloproteinase precursor [Mpl (VF0065) - Exoenzyme (VFC0251)] [Listeria monocytogenes EGD-e]
LPS gluP 0.0002285 9 VF0056 Immune modulation (rfbD) GDP-D-mannose dehydratase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695]
MprAB mprB 0.0002056 8 VF0298 Regulation (mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]
BapA bapA 0.0000457 2 VF0971 Adherence
Mycobactin mbtM 0.0000228 1 VF0299 Nutritional/Metabolic factor (mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]
SiiE siiE 0.0001371 4 VF0970 Adherence (siiE) non-fimbrial adhesin SiiE [SiiE (VF0970) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
TLH tlh 0.0000228 1 VF0610 Exotoxin (tlh) thermolabile hemolysin TLH [TLH (VF0610) - Exotoxin (VFC0235)] [Vibrio parahaemolyticus RIMD 2210633]
SCI (Salmonella centrisome island)/SPI-6 T6SS STM0267 0.0002742 6 VF0974 Effector delivery system
TTSS secreted effectors exoU 0.0000685 3 VF0853 Effector delivery system (exoT) type III secretion system effector ExoT, ADP ribosyltransferase activity and GTPase-activating protein activity [TTSS secreted effectors (VF0853) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1]
Eps T2SS VC0395_RS15460 0.0000228 1 VF0613 Effector delivery system (VC0395_RS15460) ExeA family protein [Eps T2SS (VF0613) - Effector delivery system (VFC0086)] [Vibrio cholerae O395]
VPS vpsG 0.0000457 2 VF0615 Biofilm (vpsG) exopolysaccharide biosynthesis acetyltransferase VpsG [VPS (VF0615) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961]
TTSS secreted effectors ipaH 0.0000228 1 VF0978 Effector delivery system (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301]
Urease ureG 1.0136401 43,726 VF0050 Stress survival (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695]
LPS rfbC 0.0004798 17 VF0171 Immune modulation (LPG_RS03775) NAD-dependent epimerase/dehydratase family protein [LPS (VF0171) - Immune modulation (VFC0258)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
CcmC ccmE 0.0003656 9 VF0292 Nutritional/Metabolic factor (ccmC) cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE [CcmC (VF0292) - Nutritional/Metabolic factor (VFC0272)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
EspC espC 0.0000457 1 VF0173 Effector delivery system (espC) Type III secretion system secreted protein, serine protease [EspC (VF0173) - Effector delivery system (VFC0086)] [Escherichia coli O127:H6 str. E2348/69]
Flagella flaA 0.0000914 4 VF0051 Motility (pdxA) 4-hydroxythreonine-4-phosphate dehydrogenase [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695]