Research Article Details

Article ID: A12478
PMID: 30430519
Source: Tunis Med
Title: Estimation of the prevalence of obstructive sleep apnea in non alcoholic fatty liver disease.
Abstract: INTRODUCTION: The prevalence of non alcoholic fatty liver disease is increasing in parallel with the epidemic of obesity and metabolic syndrome. Recent data have shown frequent association between non alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea. AIM: To estimate the prevalence of sleep disorders, to search an obstructive sleep apnea syndrome by conducting a ventilator polygraphy and to search the particularities of obstructive sleep apnea when its exists, in patients with NAFLD. METHODS: A prospective study, conducted over a period of 6 months, including patients followed for non-alcoholic fatty liver disease. We performed in all patients a Berlin questionnaire that assesses the risk of obstructive sleep apnea syndrome, an Epworth score that estimates the degree of daytime sleepiness and a ventilator polygraphy. RESULTS: We collected 37 patients. The mean age was 50,41±13,7 years. The sex ratio (M/F) was 0,42. Type 2 diabetes mellitus, arterial hypertension or dyslipidemia were recorded respectively in 37,8%, 40,5% and  37,8% of cases. Snoring was noted in 75,7%  of cases and excessive daytime sleepiness in 34,2% of cases. Obesity was observed in 73% and metabolic syndrome in 43,2% of cases. The Berlin Questionnaire was positive in 64,9% of cases. The average score of Epworth scale was 9,22±4,02 and 43,2% of patients had a score> 10. Ventilatorypolygraphy was positive in 13 cases (35,1%) with a mean AHI of  7,02±10,08.In these patients, obstructive sleep apnea was mild, moderate and severe in respectively 61,5%, 15,4% and 23,1% of cases. In univariate analysis, subjects with positive ventilator polygraphy had a significantly higher waist circumference (118,00 versus 109,58, p=0,05). Arterial hypertension was significantly associated with increased daytime sleepiness (p=0,018). In multivariate analysis, the only independent variable associated with excessive daytime sleepiness was arterial hypertension (OR=5,33 p=0,021). CONCLUSION: In our study, the prevalence of obstructive sleep apnea syndrome is high in patients with non alcoholic fatty liver disease. The only independent variable associated with excessive daytime sleepiness was arterial hypertension.
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Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs

Target ID Target Name GENE Action Class UniProtKB ID Entry Name

Diseases ID DO ID Disease Name Definition Class
I13 3146 Lipid metabolism disorder An inherited metabolic disorder that involves the creation and degradation of lipids. http://en.wikipedia.org/wiki/Lipid_metabolism disease of metabolism/ inherited metabolic disorder Details
I12 10763 Hypertension An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease Details
I05 9352 Type 2 diabetes mellitus A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus Details
I14 9970 Obesity An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition Details

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D328 Serine Chemical drug DB00133 SRR Improve insulin resistance Under clinical trials Details
D094 Cysteamine Chemical drug DB00847 GSS stimulant Renal drug Under clinical trials Details
D095 Cysteamine bitartrate Chemical drug DB00847 -- -- Under clinical trials Details