Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D001 | Acarbose | Chemical drug | DB00284 | MGAM inhibitor;AMY2A inhibitor; AMY2B inhibitor; GAA inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D002 | Acetaminophen | Chemical drug | DB00316 | PTGES3 inhibitor; TRPV1 activator | Antipyretic drug; non-narcotic analgesic | Under clinical trials | Details |
| D003 | Acipimox | Chemical drug | DB09055 | ADA inhibitor; TAG modulator | Hypolipidemic drug | Under clinical trials | Details |
| D005 | Aldafermin | Biological drug | DB16086 | FGF19 analog | Anti-fibrosis | Under clinical trials | Details |
| D006 | Allopurinol | Chemical drug | DB00437 | XO inhibitor | -- | Under clinical trials | Details |
| D007 | Alpha-lipoic acid | Chemical drug | DB00166 | LIPT1 | Antioxidant drug | Under clinical trials | Details |
| D008 | Alpha-tocopherol | Chemical drug | DB00163 | NR1I2; ALOX5; DGKA | -- | Under clinical trials | Details |
| D009 | ALS-L1023 | Chemical drug | -- | PPARA / Angiogenesis | Anti-inflammatory | Under clinical trials | Details |
| D010 | Amoxicillin | Chemical drug | DB01060 | -- | -- | Under clinical trials | Details |
| D011 | Anthocyanin | Chemical drug | -- | -- | Anti-inflammatory | Failed in clinical trials | Details |
| D012 | Apararenone | Chemical drug | DB15024 | Aldosterone receptor | Improve insulin resistance | Under clinical trials | Details |
| D013 | Aramchol | Chemical drug | DB11860 | SCD-1 | Enhance lipid metabolism | Under clinical trials | Details |
| D014 | ARI-3037MO | Biological drug | -- | GPR109A receptor agonist; GPR109B receptor agonist; Nicotinic acid analog | -- | Under clinical trials | Details |
| D015 | ARO-HSD | Biological drug | -- | HSD17B13 inhibitor | Hepatoprotectants | Under clinical trials | Details |
| D016 | Artichoke | Biological extract | DB10638 | -- | -- | Under clinical trials | Details |
| D017 | ASP9831 | Miscellany | -- | PDE4 inhibitor | -- | Under clinical trials | Details |
| D018 | Aspirin | Chemical drug | DB00945 | AKR1C1 inhibitor; PCNA downregulator | Enhance lipid metabolism | Under clinical trials | Details |
| D019 | Astaxanthin | Chemical drug | DB06543 | -- | -- | Under clinical trials | Details |
| D020 | Atorvastatin | Chemical drug | DB01076 | DPP4 inhibitor; AHR agonist; HDAC2 inhibitor; NR1I3 ligand | Enhance lipid metabolism | Under clinical trials | Details |
| D021 | AXA1125 | Combinatory | -- | -- | -- | Under clinical trials | Details |
| D022 | AXA1957 | Miscellany | -- | -- | Hepatoprotectants | Under clinical trials | Details |
| D023 | AZD4017 | Chemical drug | DB14875 | 11B-HSD1 inhibitor | -- | Under clinical trials | Details |
| D024 | AZD4076 | Biological drug | -- | miR-103 antagonist;miR-107 antagonist | -- | Under clinical trials | Details |
| D025 | Azithromycin | Chemical drug | DB00207 | -- | -- | Under clinical trials | Details |
| D026 | Bacillus coagulans | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D027 | Bayberry Juice | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D028 | Belapectin | Chemical drug | DB15125 | Gelactin-3 inhibitor; LGALS3 inhibitor | Anti-fibrosis | Failed in clinical trials | Details |
| D029 | Berberine | Chemical drug | DB04115 | AMPK activator | Improve insulin resistance | Under clinical trials | Details |
| D030 | Bergamot | Biological drug | DB14335 | -- | Enhance lipid metabolism | Under clinical trials | Details |
| D031 | Besifovir | Chemical drug | DB15671 | DNA-directed DNA polymerase; Hepatitis B virus replication | -- | Under clinical trials | Details |
| D032 | Betaine | Chemical drug | DB06756 | DNMTs stimulant | Improve insulin resistance | Under clinical trials | Details |
| D033 | Bezafibrate | Chemical drug | DB01393 | PPARA agonist; PPARD agonist; PPARG agonist; NR1I2 partial agonist | Improve insulin resistance; Anti-inflammatory | Under clinical trials | Details |
| D034 | BFKB8488A | Biological drug | -- | KLB inhibitor; Type 1 FGFR antagonist | -- | Under clinical trials | Details |
| D035 | Bhunimba kshara | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D036 | BI 1467335 | Chemical drug | -- | AOC3 activator | -- | Failed in clinical trials | Details |
| D037 | Bifidobacterium longum | Biological drug | DB14222 | -- | -- | Under clinical trials | Details |
| D038 | Biguanide | Chemical drug | DB13100 | -- | -- | Under clinical trials | Details |
| D039 | Bio-25 | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D040 | BIO89-100 | Biological drug | -- | FGF21 analog | Improve insulin resistance; Enhance lipid metabolism | Under clinical trials | Details |
| D041 | BioE-1115 | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D042 | BioFemale | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D043 | Bismuth subcitrate | Chemical drug | DB09275 | -- | -- | Under clinical trials | Details |
| D044 | Black cumin | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D045 | BLD-0409 | Miscellany | -- | ENPP2 inhibitor; ATX inhibitor | Anti-fibrosis | Under clinical trials | Details |
| D046 | Pegbelfermin | Biological drug | DB15365 | FGF21 analog | Improve insulin resistance; Enhance lipid metabolism; Anti-fibrosis | Under clinical trials | Details |
| D047 | BMS-986251 | Chemical drug | -- | RORGt inverse agonist | -- | Failed in clinical trials | Details |
| D048 | BMS-986263 | Biological drug | -- | HSP inhibitor | -- | Under clinical trials | Details |
| D049 | Bovine Colostrum | Supplement | -- | -- | -- | Under clinical trials | Details |
| D050 | Branched-chain amino acids | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D051 | Brewed chicory leaf | Herbal medicine | -- | -- | -- | Under clinical trials | Details |