Research Article Details

Article ID: A12949
PMID: 30213101
Source: Int J Mol Sci
Title: NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation.
Abstract: In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or "alarmin", which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.
DOI: 10.3390/ijms19092732