Research Article Details
| Article ID: | A16960 |
| PMID: | 28073424 |
| Source: | Zhonghua Gan Zang Bing Za Zhi |
| Title: | [NACHT-LRR-PYD-containing proteins 3 inflammasome and nonalcoholic fatty liver disease]. |
| Abstract: | NACHT-LRR-PYD-containing proteins 3 (NLRP3) inflammasome regulates the maturation and secretion of proinflammatory cytokines including interleukin-1β and interleukin-18, as well as immune and inflammatory response, through the activation of cysteine aspartate specific protease-1. Inflammatory response caused by the activation of NLRP3 inflammasome may participate in the development and progression of nonalcoholic fatty liver disease (NAFLD). Therefore, exploration of the role of NLRP3 inflammasome in NAFLD is important for the understanding of the pathogenesis of NAFLD and discovery of new therapeutic targets. |
| DOI: | 10.3760/cma.j.issn.1007-3418.2016.12.019 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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