Research Article Details

Article ID: A17349
PMID: 27831641
Source: Eur Rev Med Pharmacol Sci
Title: Metabolic syndrome is a risk factor for nonalcoholic fatty liver disease: evidence from a confirmatory factor analysis and structural equation modeling.
Abstract: OBJECTIVE: It has been demonstrated that nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome (MS). This study used confirmatory factor analysis (CFA) and structural equation modeling (SEM) to characterize the relationship between MS and NAFLD. PATIENTS AND METHODS: A cross-sectional study was performed on 3440 NAFLD patients. Of the 3440 subjects, 1160 were diagnosed with MS. BMI, SBP, DBP, UN, Scr, UA, FPG, Fructosamine, TC, TG, lipoprotein alpha, HDL-C, LDL-C, ALT, AST, TP, albumin, globulins, TB, DB, ALP and GGT were measured. CFA was used to identify a latent structure of NAFLD and MS, respectively. SEM approach was used to analyze the latent relationship between MS and NAFLD. RESULTS: Second-order CFA revealed that the observed variables for NAFLD could be loaded onto seven latent factors, which were further loaded together onto an unobserved NAFLD factor. CFA of MS showed that overweight, hyperglycemia, dyslipidemia, and hypertension clustered together under a single latent factor of MS. In both MS and NAFLD models, hypertension showed higher factor loading than other factors. Factor models of MS and NAFLD showed a good fit to the data. As a latent factor, MS was significantly associated with increased risk of NAFLD. CONCLUSIONS: MS may be a risk factor of NAFLD. MS and its components may play important roles in the development of NAFLD.
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Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs

Target ID Target Name GENE Action Class UniProtKB ID Entry Name

Diseases ID DO ID Disease Name Definition Class
I13 3146 Lipid metabolism disorder An inherited metabolic disorder that involves the creation and degradation of lipids. http://en.wikipedia.org/wiki/Lipid_metabolism disease of metabolism/ inherited metabolic disorder Details
I12 10763 Hypertension An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease Details
I05 9352 Type 2 diabetes mellitus A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus Details
I14 9970 Obesity An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition Details

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D328 Serine Chemical drug DB00133 SRR Improve insulin resistance Under clinical trials Details
D316 S-adenosyl-L-methionine Chemical drug DB00118 GNMT cofactor Antiviral Under clinical trials Details
D094 Cysteamine Chemical drug DB00847 GSS stimulant Renal drug Under clinical trials Details
D095 Cysteamine bitartrate Chemical drug DB00847 -- -- Under clinical trials Details