Research Article Details
| Article ID: | A18708 |
| PMID: | 26988666 |
| Source: | Cancer Discov |
| Title: | CD4+ T Cell Loss Drives NAFLD Progression to Hepatocellular Carcinoma. |
| Abstract: | Dysregulated lipid metabolism in NAFLD promotes hepatocarcinogenesis via loss of CD4(+) T cells. |
| DOI: | 10.1158/2159-8290.CD-RW2016-046 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
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