Research Article Details
| Article ID: | A19183 |
| PMID: | 29190058 |
| Source: | Duodecim |
| Title: | Diagnosis of nonalcoholic fatty liver disease (NAFLD). |
| Abstract: | Nonalcoholic fatty liver disease (NAFLD) increases mortality from liver and heart disease and is the most important cause of hepatocellular carcinoma (HCC), which is rapidly becoming more common. Those having an increased fibrosis risk, cirrhosis or HCC should be identified amongst those with simple steatosis. Liver enzymes should always be determined at the yearly follow-up of patients with type 2 diabetes and those with the metabolic syndrome. Fatty liver should lead to an assessment of the risk of fibrosis by using a simple fibrosis test and to the referral of patients at risk by a specialist for diagnosis and treatment of NASH and fibrosis. NASH can only be diagnosed using a liver biopsy. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S03 | Anti-fibrosis | fibrosis | Angiotensin Receptor Blocker (ARB); CCR2/CCR5 antagonist; Thyroid receptor β agonist; PEGylated human FGF21 analogue; Monoclonal antibody to lysyl oxidase-like 2 (LOXL2); Galectin-3 inhibitor; FGF19 variant | Losartan; Cenicriviroc; VK-2809; MGL-3196; Pegbelfermin; Simtuzumab; GR-MD-02; NGM282 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|