| Abstract: | OBJECTIVE: To determine the prevalence of non-alcoholic fatty liver disease (NAFLD) and associated risk factors in a group of managers from the Community of Madrid. METHODS: Retrospective cross-sectional study of 1838 workers (78.5% male) who underwent medical examination between January 1, 2010 and December 31, 2010 as part of a worker health surveillance program. Data were collected from medical records, laboratory results, anthropometric measurements and hepatic ultrasound. RESULTS: The prevalence of NAFLD was 44.0%: 54.0% in men and 7.3% in women (p<0.001). In both sexes, NAFLD was associated with increasing age, higher weight, shorter stature, higher body mass index, waist circumference and metabolic syndrome, as well as higher levels of uric acid and blood glucose. In the multivariate logistic regression analysis, the risk of NAFLD risk was associated with an abdominal circumference ≥ 102cm for men and ≥ 88cm in women (OR=5.2; 95%CI 3.8-7.1 ), age ≥ 40 years (OR : 3.0; 95%CI 2.3-4.0), triglycerides ≥ 150mg/dl (OR=2.1; 95%CI 1.5-2.8), HDL cholesterol <45mg/dl in women and <40mg/dl in men (OR=1.6; 95%CI 1.1-2.2), and total cholesterol >200/dl mg (OR=1.4; 95%CI 1.0-1.9). CONCLUSIONS: NAFLD prevalence is notably different among sexes and is associated with hypertriglyceridemia, hypercholesterolemia, low HDL cholesterol, abdominal obesity and metabolic syndrome. Screening programs for NAFLD in worker medical surveillance programs could be of interest in occupational medicine. |
