Research Article Details
| Article ID: | A22693 |
| PMID: | 25842663 |
| Source: | Eksp Klin Gastroenterol |
| Title: | [Prevalence of nonalcoholic fatty liver disease in young patients with abdominal obesity and hypertension]. |
| Abstract: | THE AIM: To estimate the incidence of nonalcoholic fatty liver disease and the factors of cardiovascular risk in young patients with abdominal obesity and hypertension compared to persons with isolated forms of these diseases. MATERIALS AND METHODS: Studied 127 patients aged 18-44 years with presence of abdominal obesity and/or hypertension. The factors of cardiovascular risk were evaluated. Laboratory examination included the determination of parameters of lipid metabolism, glucose and uric acid. The liver ultrasound was processed. In 61.3% of young patients with abdominal obesity and hypertension identified laboratory and instrumental signs of nonalcoholic fatty liver disease. In patients with abdominal obesity and hypertension were more prevalent family history of hypertension, smoking, dyslipidemia, mainly due to triglycerides, as well as higher levels of fasting glucose. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |
| I13 | 3146 | Lipid metabolism disorder | An inherited metabolic disorder that involves the creation and degradation of lipids. http://en.wikipedia.org/wiki/Lipid_metabolism | disease of metabolism/ inherited metabolic disorder | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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