Research Article Details
| Article ID: | A22809 |
| PMID: | 26202297 |
| Source: | Hepatol Int |
| Title: | Non-alcoholic fatty liver disease-related hepatocellular carcinoma: a sleeping tiger in the Asia Pacific. |
| Abstract: | The epidemiology of hepatocellular carcinoma (HCC) in the Asia Pacific will undergo significant change over the next few decades as the prevalence of viral hepatitis declines and the burden of metabolic diseases increases. As the Asia Pacific embraces continued affluence, obesity and diabetes rates are burgeoning, becoming increasingly important to the incidence of HCC. Obesity and diabetes are established risk factors for HCC, either as substrates for non-alcoholic fatty liver disease (NAFLD) or as independent carcinogens themselves. This review summarises the epidemiological data on changing HCC trends in the Asia Pacific, particularly as it pertains to the emerging problem of NAFLD-related HCC. |
| DOI: | 10.1007/s12072-013-9453-0 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
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| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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