Research Article Details
Article ID: | A24681 |
PMID: | 22613376 |
Source: | Zhonghua Liu Xing Bing Xue Za Zhi |
Title: | [Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease]. |
Abstract: | OBJECTIVE: To examine the relationships between the level of serum visfatin and obesity, nonalcoholic fatty liver disease (NAFLD) in children and adolescents. METHODS: Serum visfatin levels of 106 obese children/adolescents (including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones, 15 moderate-to-severe ones) with another 69 lean children/adolescents as their controls, were examined by indirect sandwich ELISA. RESULTS: When comparing the serum visfatin levels, there was no significant difference noticed between the obese group (1.71±0.37) ng/ml and the lean group (1.75±0.37) ng/ml (P=0.455). With the severity of NAFLD, the serum visfatin level showed an elevation in obese children and adolescents [obese without NAFLD (1.59±0.36) ng/ml, obese with mild NAFLD (1.74±0.36) ng/ml, obese with moderate-to-severe NAFLD (1.97±0.36) ng/ml, P<0.05]. In the obese group, serum visfatin levels seemed to be related to age (β=-0.326, P=0.000), alanine aminotransferase (ALT) (β=0.286, P=0.004) and the degree of NAFLD (β=0.246, P=0.014). CONCLUSION: The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent. |
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Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
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Diseases ID | DO ID | Disease Name | Definition | Class | |
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I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
---|---|---|---|---|---|---|---|
D240 | Nicotinamide | Chemical drug | DB02701 | PARP inhibitor | Metabolic disorder drug | Under clinical trials | Details |
D328 | Serine | Chemical drug | DB00133 | SRR | Improve insulin resistance | Under clinical trials | Details |
D199 | L-alanine | Chemical drug | DB00160 | KYNU | -- | Failed in clinical trials | Details |