Research Article Details
| Article ID: | A02624 |
| PMID: | 34305351 |
| Source: | J Clin Exp Hepatol |
| Title: | SARS-CoV-2 infection in Liver Transplant recipients - Immunosuppression is the silver lining? |
| Abstract: | Introduction: COVID-19 is associated with higher mortality among patients who have comorbidities. However, data related to COVID-19 among post liver transplant recipients is scarce and evolving. Methods: Adult Indian patients who had undergone liver transplantation at our centre since 2006 and were under regular follow-up, were contacted either telephonically or on email. Data was recorded related to symptoms & diagnosis of COVID-19, need for hospitalization, and need for ICU stay and mortality. Results: 81 (3.71%) of the 2182 adult Liver transplant (LT) recipients on regular follow-up reported SARS-CoV-2 infection between 1st April 2020 and 31st May 2021. Mean age was 51.3(±9.8) years, and 74(91.4%) were males. 35(43.2%) patients had one or more comorbidities. 21(25.9%) patients were transplanted less than 1 year ago. 44 (54.3%) patients had mild disease only while 23(28.4%) patients had severe COVID-19 disease. Out of 81 patients 14 patients died and overall mortality was 17.3%. Conclusion: Uncomplicated liver transplant recipients without comorbidities who acquire SARS-CoV-2 don't have poor outcome. |
| DOI: | 10.1016/j.jceh.2021.07.005 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D579 | Emfilermin | Miscellany | -- | adipocytes | Enhance lipid metabolism | Under investigation | Details |
| D094 | Cysteamine | Chemical drug | DB00847 | GSS stimulant | Renal drug | Under clinical trials | Details |
| D095 | Cysteamine bitartrate | Chemical drug | DB00847 | -- | -- | Under clinical trials | Details |