Research Article Details
| Article ID: | A27621 |
| PMID: | 17900249 |
| Source: | Liver Int |
| Title: | Clinicopathological improvement of non-alcoholic steatohepatitis associated with weight loss during a 14-year follow-up period. |
| Abstract: | A 44-year-old woman was admitted to our hospital for investigation of persistently abnormal liver function tests. She was mildly obese and hypertensive, but not alcoholic. Laboratory studies showed high levels of aminotransferases, total cholesterol, triglycerides, hyaluronic acid and an abnormally low adiponectin level. Viral markers were negative and autoimmune liver disease was excluded. Laparoscopic and histopathological examinations were compatible with non-alcoholic steatohepatitis (NASH), grade 1, stage 2. The patient developed diabetes 2 years after the first examination, and weight management was provided. She was admitted again to our hospital 14 years later. Her body weight had since decreased by 12 kg and laboratory studies disclosed high triglycerides, normalization of aminotransferases and adiponectin in parallel with body weight loss. Laparoscopic and histopathological examinations were compatible with NASH, grade 1, stage 0, indicating improvement relative to the first admission. We report on a case of NASH with reduction of body weight within a period of 14 years, associated with clinicopathological improvement. |
| DOI: | 10.1111/j.1478-3231.2007.01574.x |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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