Research Article Details
| Article ID: | A28280 |
| PMID: | 15823438 |
| Source: | Gastroenterol Clin North Am |
| Title: | Hepatic complications of obesity. |
| Abstract: | Obesity increases the risk and severity of liver disease. The most common form of liver disease that occurs in obesity is NAFLD. A better understanding of the basic disease mechanisms and natural histories ofNAFLD is needed to guide management and treatment of obese patients and others with this disorder. Large, prospective, randomized, controlled treatment trials also are needed. Ideally, such studies will focus on well-defined patient subsets and monitor the impact of therapy on clinically relevant endpoints, such as liver-related morbidity and mortality. |
| DOI: | 10.1016/j.gtc.2004.12.012 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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