Research Article Details
| Article ID: | A33781 |
| PMID: | 25168747 |
| Source: | Bioorg Med Chem Lett |
| Title: | NaSH in the construction of thiophene ring fused with N-heterocycles: a rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis. |
| Abstract: | A facile construction of a thiophene ring fused with N-heterocycles has been achieved via the reaction of NaSH with 2-chloro-3-alkynyl quinoxalines/pyrazines leading to novel 2-substituted thieno[2,3-b]pyrazine/quinoxaline derivatives as potential inducers of apoptosis. Some of them showed encouraging pharmacological properties when tested in zebrafish. |
| DOI: | 10.1016/j.bmcl.2014.07.096 |
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