Research Article Details
| Article ID: | A36403 |
| PMID: | 18278938 |
| Source: | J Org Chem |
| Title: | Synthesis of cyclic thioethers through tandem C(sp3)-S and C(sp2)-S bond formations from alpha,beta'-dichloro vinyl ketones. |
| Abstract: | The synthesis of 5- to 8-memebered cyclic thioethers 4 has been achieved through a simple two-step sequence. The present methodology utilizes the facile Friedel-Crafts acylation of terminal alkynes 1 with acid chlorides 2 followed by tandem C(sp(3))-S and C(sp(2))-S bond formations with NaSH.xH(2)O. |
| DOI: | 10.1021/jo702457t |
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