Research Article Details
| Article ID: | A38011 |
| PMID: | 12510275 |
| Source: | Chem Commun (Camb) |
| Title: | Cathodically activated nucleophilic aromatic substitution of hydrogen: a novel electrochemical mechanism. |
| Abstract: | Cathodically activated nucleophilic aromatic substitution of hydrogen (SNArH) is reported for the first time; the 1,3,5-trinitrobenzene radical anion reacts with the nucleophile N-methylformamide leading to high yields of the sigma H-complex radical anion; this intermediate can be easily oxidised electrochemically by means of a three-electron mechanism giving rise to the nucleophilic aromatic substitution product (NASH product) in good yield. |
| DOI: | 10.1039/b207168a |
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