Research Article Details

Article ID: A44085
PMID: 29867233
Source: Nat Med
Title: Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates.
Abstract:
DOI: 10.1038/s41591-018-0062-2

Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs
S17 Genetic therapy Genetic approaches; genetherapy; Gene therapy HSD17B13 inhibitor; PNPLA3-rs7 38409 (I148M) variant inhibitor; PNPLA3 expression down-regulator INI-678; Momelotinib Details
S13 Anti-apoptosis hepatocyte apoptosis; hepatic autophagy; apoptosis Pan-caspase inhibitor Emricasan Details

Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T10 Caspase-1 CASP1 inhibitor Enzyme P29466 CASP1_HUMAN Details
T20 Fatty acid synthase FASN inhibitor Enzyme P49327 FAS_HUMAN Details

Diseases ID DO ID Disease Name Definition Class

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress