Research Article Details
| Article ID: | A49014 |
| PMID: | 21329483 |
| Source: | Scand J Urol Nephrol |
| Title: | Management of diuretic treatment: a challenge in the obese patient. |
| Abstract: | The obesity epidemic is a major health concern. The diagnosis of acute illness and fluid imbalance in the obese patient is complicated by a wide range of comorbidities such as cardiovascular disease, obesity hypoventilation syndrome, non-alcoholic steatohepatitis and lymphoedema. Thus, obesity warrants particularly careful clinical and biochemical assessment owing to its resemblance to fluid retention. Dosing of diuretics is difficult in these patients. The blood urea:creatinine ratio should be widely used to detect emerging cardiovascular and renal complications. This report presents an obese patient with congestive heart failure due to a myocardial infarction, who subsequently was overdosed with diuretics. His prerenal acute renal failure resolved when diuretics were stopped and the high urea:creatinine ratio was diagnostic. |
| DOI: | 10.3109/00365599.2011.552435 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |