| Abstract: | Purpose - to assess the probability of occurrence of the main cardiovascular events in the patients after revascularization interventions with a combined course of a stable coronary heart disease and non-alcoholic steatohepatitis (NASH) by indicators of fibrogenesis. 164 patients with stable coronary heart disease were observed, including: 54 patients with NASH (a main group); 110 patients without NASH (a comparison group). All patients underwent general clinical examination, electrocardiography, coronary angiography, echocardiography, assessment of liver function, markers of fibrosis and long-term prognosis by the Kaplan-Meier method. It was found that the patients with stable coronary heart disease, combined with NASH, are characterized by the fibrosis progression, that is characterized by a significantly high value of fibrogenesis markers. The presence of NASH in patients with stable coronary heart disease causes a worsening of the disease and forms a negative prognosis in such patients in a two-year term. The prognosis of the patients who underwent coronary artery stenting depends on the course of non-alcoholic fatty liver disease and is the most prognostically unfavorable against the combination of the FIB-4 index ≥2.0 and NASH. |
