Research Article Details
| Article ID: | A05223 |
| PMID: | 33333240 |
| Source: | Respir Physiol Neurobiol |
| Title: | Functional foods from the tropics to relieve chronic normobaric hypoxia. |
| Abstract: | Functional foods with antioxidant and anti-inflammatory properties are regarded as a complementary therapy to improve chronic diseases such as obesity and inflammatory bowel disease (IBD). Obesity is a chronic low-grade inflammatory state leading to organ damage with increased risk of common diseases including cardiovascular and metabolic disease, non-alcoholic fatty liver disease, osteoarthritis and some cancers. IBD is a chronic intestinal inflammation categorised as Crohn's disease and ulcerative colitis depending on the location of inflammation. These inflammatory states are characterised by normobaric hypoxia in adipose and intestinal tissues, respectively. Tropical foods especially from Australia and South America are discussed in this review to show their potential in attenuation of these chronic diseases. The phytochemicals from these foods have antioxidant and anti-inflammatory activities to reduce chronic normobaric hypoxia in the tissues. These health benefits of the tropical foods are relevant not only for health economy but also in providing a global solution by improving the sustainability of their cultivation and assisting the local economies. |
| DOI: | 10.1016/j.resp.2020.103599 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I11 | 5295 | Intestinal disease | A gastrointestinal system disease that is located_in the intestine. http://en.wikipedia.org/wiki/Human_gastrointestinal_tract | disease of anatomical entity/gastrointestinal system disease | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |