Research Article Details
| Article ID: | A09816 |
| PMID: | 31599742 |
| Source: | Am J Gastroenterol |
| Title: | The Impact of Obesity and Type 2 Diabetes on Chronic Liver Disease. |
| Abstract: | The growing global epidemic of obesity and type 2 diabetes mellitus (T2DM) has led to the increasing prevalence of nonalcoholic fatty liver disease. In addition, the presence of obesity and T2DM has been shown to increase the likelihood of adverse outcomes in patients with chronic liver disease. In a study by Harris et al., a combination of obesity and T2DM was associated with an increased risk for higher liver stiffness, as measured by transient elastography. It is possible that public health and clinical intervention targeting these components of metabolic syndrome can lead to improved outcomes of subjects with nonalcoholic fatty liver disease and other chronic liver diseases. |
| DOI: | 10.14309/ajg.0000000000000433 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D080 | Citrulline | Chemical drug | DB00155 | -- | -- | Under clinical trials | Details |
| D094 | Cysteamine | Chemical drug | DB00847 | GSS stimulant | Renal drug | Under clinical trials | Details |
| D095 | Cysteamine bitartrate | Chemical drug | DB00847 | -- | -- | Under clinical trials | Details |