Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A45575 | 23813872 | Hepatology | High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. | 2013 | Details |
| A45623 | 23599638 | World J Gastroenterol | Alcohol consumption and fatty liver disease. | 2013 | Details |
| A45634 | 23512597 | Obesity (Silver Spring) | Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats. | 2013 | Details |
| A45641 | 23493541 | Adv Nutr | Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism. | 2013 | Details |
| A45642 | 23493538 | Adv Nutr | Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. | 2013 | Details |
| A45662 | 23401290 | Hepatology | Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease. | 2013 | Details |
| A45684 | 23295629 | Food Chem Toxicol | Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation. | 2013 | Details |
| A45709 | 23161873 | Endocrinology | The role of the carbohydrate response element-binding protein in male fructose-fed rats. | 2012 | Details |
| A45726 | 23053554 | Am J Clin Nutr | Mitigating factors and metabolic mechanisms in fructose-induced nonalcoholic fatty liver disease: the next challenge. | 2012 | Details |
| A45729 | 23035112 | J Biol Chem | Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. | 2012 | Details |
| A45854 | 22371574 | Proc Natl Acad Sci U S A | Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. | 2012 | Details |
| A45908 | 22144172 | Genes Nutr | Nutrigenomics of hepatic steatosis in a feline model: effect of monosodium glutamate, fructose, and Trans-fat feeding. | 2011 | Details |
| A45960 | 21841000 | J Biol Chem | L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. | 2011 | Details |
| A45965 | 21807932 | JPEN J Parenter Enteral Nutr | Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. | 2011 | Details |
| A45999 | 21661508 | Diabetes Self Manag | High-fructose corn syrup. What's all the fuss about? | 2011 | Details |
| A46037 | 21472743 | Hepatology | Two solutions in search of a problem. | 2011 | Details |
| A46064 | 21338637 | J Hepatol | Non-alcoholic fatty liver disease and fructose: bad for us, better for mice. | 2011 | Details |
| A46136 | 20814895 | Hepatology | Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis. | 2010 | Details |
| A46221 | 20211973 | Endocrinology | Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet. | 2010 | Details |
| A46306 | 19616615 | Free Radic Biol Med | SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. | 2009 | Details |
| A46311 | 19581556 | Arch Pediatr Adolesc Med | Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study. | 2009 | Details |
| A46336 | 19463838 | Toxicol Appl Pharmacol | Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity. | 2009 | Details |
| A46345 | 19403641 | Am J Clin Nutr | Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. | 2009 | Details |
| A46452 | 18542010 | Curr Opin Clin Nutr Metab Care | Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease. | 2008 | Details |
| A46889 | 11296700 | Semin Liver Dis | Animal models of steatosis. | 2001 | Details |
| A47087 | 26493454 | BMC Syst Biol | Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes. | 2015 | Details |
| A47249 | 21423135 | Lab Invest | Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. | 2011 | Details |
| A47296 | 18541827 | Arch Intern Med | Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. | 2008 | Details |
| A47658 | 34135298 | J Pediatr Gastroenterol Nutr | A Diet High in Fat and Fructose Induces Early Hepatic Mitochondrial Aging. | 2021 | Details |
| A47778 | 32065514 | Clin Pharmacol Drug Dev | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study. | 2020 | Details |
| A47796 | 31735070 | Curr Eye Res | Diet Mimicking "Fast Food" Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration. | 2019 | Details |
| A47939 | 28708468 | J Med Food | A Botanical Composition from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis for Body Weight Management. | 2017 | Details |
| A48065 | 27278026 | J Med Ultrason (2001) | Real-time tissue elastography (RTE) for noninvasive evaluation of fibrosis in liver diseases in children in comparison to liver biopsy. | 2014 | Details |
| A48067 | 25213859 | J Biol Chem | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. | 2014 | Details |
| A48446 | 10553793 | JAMA | Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. | 1999 | Details |
| A48507 | 35123128 | Mol Metab | Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis. | 2022 | Details |
| A48567 | 33917706 | Pharmaceutics | Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model. | 2021 | Details |
| A48812 | 27774805 | Orv Hetil | [Fructose and fructose intolerance]. | 2016 | Details |
| A48972 | 22721876 | Nutrition | Caffeine attenuates metabolic syndrome in diet-induced obese rats. | 2012 | Details |
| A48997 | 21999649 | Paediatr Drugs | Medical management of chronic liver diseases in children (part I): focus on curable or potentially curable diseases. | 2011 | Details |
| A49175 | 15489566 | Eur J Gastroenterol Hepatol | Mitochondrial injury in steatohepatitis. | 2004 | Details |
| A49234 | 35813333 | Ann Transl Med | Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice. | 2022 | Details |
| A49352 | 35780841 | Life Sci | Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q/tumor necrosis factor-related protein-3 and ATP citrate lyase. | 2022 | Details |
| A49355 | 35779864 | Drug Metab Dispos | Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease. | 2022 | Details |
| A49430 | 35751193 | Comput Biol Med | Exploring the possible molecular targeting mechanism of Saussurea involucrata in the treatment of COVID-19 based on bioinformatics and network pharmacology. | 2022 | Details |
| A49465 | 35743870 | Life (Basel) | The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population-A Review. | 2022 | Details |
| A49467 | 35743821 | Life (Basel) | Neonatal Oral Administration of Chrysin Prevents Long-Term Development of Non-Alcoholic Fatty Liver Disease in a Sexually Dimorphic Manner in Fructose Nurtured Sprague Dawley Rats. | 2022 | Details |
| A49489 | 35739588 | Genome Med | Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease. | 2022 | Details |
| A49520 | 35728768 | Free Radic Biol Med | Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2. | 2022 | Details |
| A49521 | 35728124 | Diabetes Metab Res Rev | Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity. | 2022 | Details |
| A49544 | 35720181 | Oxid Med Cell Longev | Chrysin Attenuates Fructose-Induced Nonalcoholic Fatty Liver in Rats via Antioxidant and Anti-Inflammatory Effects: The Role of Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis. | 2022 | Details |
| A49562 | 35713152 | J Cell Mol Med | Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway. | 2022 | Details |
| A49577 | 35708630 | J Med Food | Nil-Surin Rice Bran Hydrolysates Improve Lipid Metabolism and Hepatic Steatosis by Regulating Secretion of Adipokines and Expression of Lipid-Metabolism Genes. | 2022 | Details |
| A49609 | 35692676 | J Clin Biochem Nutr | Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat. | 2022 | Details |
| A49615 | 35691075 | Phytomedicine | Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. | 2022 | Details |
| A49637 | 35683997 | Nutrients | Mega-Dose Vitamin C Ameliorates Nonalcoholic Fatty Liver Disease in a Mouse Fast-Food Diet Model. | 2022 | Details |
| A49683 | 35672152 | Pharm Biol | Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats. | 2022 | Details |
| A49727 | 35656562 | Diabetes Metab J | Lifestyle Interventions for Non-Obese Patients Both with, and at Risk, of Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A49739 | 35654114 | Metabolism | GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease. | 2022 | Details |
| A49746 | 35651514 | Front Nutr | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet. | 2022 | Details |
| A49767 | 35643859 | Lab Invest | A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis. | 2022 | Details |
| A49770 | 35643287 | J Nutr Biochem | Opisthorchis viverrini infection induces metabolic disturbances in hamsters fed with high fat/high fructose diets: Implications for liver and kidney pathologies. | 2022 | Details |
| A49775 | 35642168 | Sichuan Da Xue Xue Bao Yi Xue Ban | [Research Progress in High-Sugar Diet and Inflammatory Diseases]. | 2022 | Details |
| A49839 | 35624762 | Antioxidants (Basel) | Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice. | 2022 | Details |
| A49841 | 35624731 | Antioxidants (Basel) | Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis. | 2022 | Details |
| A49883 | 35609854 | J Nutr Biochem | Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes. | 2022 | Details |
| A49931 | 35590219 | Med (N Y) | Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial. | 2021 | Details |
| A50068 | 35537139 | Food Funct | Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress. | 2022 | Details |
| A50078 | 35535064 | J Clin Exp Hepatol | Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs. | 2021 | Details |
| A50092 | 35531334 | Front Cell Infect Microbiol | Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice via Gut Microbiota. | 2022 | Details |
| A50160 | 35499800 | Biol Trace Elem Res | Selenium-Enriched Probiotic Alleviates Western Diet-Induced Non-alcoholic Fatty Liver Disease in Rats via Modulation of Autophagy Through AMPK/SIRT-1 Pathway. | 2022 | Details |
| A50177 | 35489641 | Ann Hepatol | Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease. | 2022 | Details |
| A50259 | 35451807 | Curr Med Sci | Efficacy of Sitagliptin on Nonalcoholic Fatty Liver Disease in High-fat-diet-fed Diabetic Mice. | 2022 | Details |
| A50274 | 35447548 | Biomed Pharmacother | Downregulation of hepatic fat accumulation, inflammation and fibrosis by nerolidol in purpose built western-diet-induced multiple-hit pathogenesis of NASH animal model. | 2022 | Details |
| A50306 | 35437549 | Food Funct | L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats. | 2022 | Details |
| A50372 | 35413401 | Biochim Biophys Acta Mol Basis Dis | The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression. | 2022 | Details |
| A50576 | 35334784 | Nutrients | Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review. | 2022 | Details |
| A50627 | 35322435 | J Food Biochem | Chia seeds and chemical-elicited sprouts supplementation ameliorates insulin resistance, dyslipidemia, and hepatic steatosis in obese rats. | 2022 | Details |
| A50643 | 35317606 | Thyroid | Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis. | 2022 | Details |
| A50703 | 35294499 | PLoS One | Steatosis is involved in the progression of kidney disease in a high-fat-diet-induced non-alcoholic steatohepatitis mouse model. | 2022 | Details |
| A50725 | 35286786 | Z Naturforsch C J Biosci | Establishment and metabonomics analysis of nonalcoholic fatty liver disease model in golden hamster. | 2022 | Details |
| A50756 | 35276968 | Nutrients | Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model. | 2022 | Details |
| A50810 | 35218717 | Eur J Pharmacol | HA-20 prevents hepatocyte steatosis in metabolic-associated fatty liver disease via regulating Ca2+ relative signalling pathways. | 2022 | Details |
| A50850 | 34984708 | Hepatology | Letter to the editor: The multiple mechanisms of fructose disrupt gut-liver axis and metabolic regulation. | 2022 | Details |
| A50890 | 34271222 | Mol Metab | Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease. | 2021 | Details |
| A50911 | 33731774 | Acta Pharmacol Sin | Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease. | 2021 | Details |
| A51146 | 35477568 | Cell Death Discov | Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis. | 2022 | Details |
| A51152 | 35460276 | Hepatology | Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. | 2022 | Details |
| A51153 | 35458210 | Nutrients | The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults. | 2022 | Details |
| A51386 | 30887836 | Bioanalysis | Development and validation of a quantitative ultra performance LC® hydrophilic interaction liquid chromatography MS/MS method to measure fructose and sorbitol in human plasma. | 2019 | Details |
| A51409 | 35749827 | Phytomedicine | Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway. | 2022 | Details |
| A51434 | 35421426 | J Hepatol | Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice. | 2022 | Details |
| A51637 | 35453816 | Biology (Basel) | High-Fructose Diet Increases Renal ChREBPβ Expression, Leading to Intrarenal Fat Accumulation in a Rat Model with Metabolic Syndrome. | 2022 | Details |
| A51713 | 34687058 | J Inherit Metab Dis | Fructose-1,6-bisphosphatase deficiency causes fatty liver disease and requires long-term hepatic follow-up. | 2021 | Details |
| A51731 | 34510498 | Hepatology | Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals. | 2021 | Details |
| A51760 | 34303283 | Tissue Cell | CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress. | 2021 | Details |
| A51762 | 34302121 | Int J Obes (Lond) | Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. | 2021 | Details |
| A51955 | 32917715 | Sci Adv | Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis. | 2020 | Details |
| A52012 | 32303571 | Dis Model Mech | A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction. | 2020 | Details |
| A52079 | 31577934 | Cell Metab | Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. | 2019 | Details |