Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A06855 | 32720691 | Hum Mol Genet | Insights into genetic variants associated with NASH-fibrosis from metabolite profiling. | 2020 | Details |
| A06862 | 32718371 | Br J Nutr | Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway. | 2020 | Details |
| A06863 | 32718364 | Br J Nutr | Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice. | 2020 | Details |
| A06868 | 32717288 | J Hepatol | Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A06873 | 32715385 | Arch Pharm Res | Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. | 2020 | Details |
| A06874 | 32715106 | Biochem Biophys Rep | Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress. | 2020 | Details |
| A06877 | 32712601 | Aging (Albany NY) | Decreased autophagy and fuel switching occur in a senescent hepatic cell model system. | 2020 | Details |
| A06880 | 32712045 | Asian J Surg | Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice. | 2020 | Details |
| A06890 | 32708036 | Nutrients | The Importance of the Fatty Acid Transporter L-Carnitine in Non-Alcoholic Fatty Liver Disease (NAFLD). | 2020 | Details |
| A06906 | 32702444 | Life Sci | A tRNA-derived fragment (tRF-3001b) aggravates the development of nonalcoholic fatty liver disease by inhibiting autophagy. | 2020 | Details |
| A06909 | 32700545 | Biol Res Nurs | Oral Probiotic Bifidobacterium Longum Supplementation Improves Metabolic Parameters and Alters the Expression of the Renin-Angiotensin System in Obese Mice Liver. | 2020 | Details |
| A06919 | 32698042 | Cell Mol Gastroenterol Hepatol | Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes. | 2020 | Details |
| A06930 | 32694843 | Nat Metab | Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. | 2019 | Details |
| A06934 | 32694515 | Sci Rep | The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice. | 2020 | Details |
| A06951 | 32688339 | Endocr Connect | FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation. | 2020 | Details |
| A06955 | 32687428 | Autophagy | Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation. | 2020 | Details |
| A06962 | 32685690 | Hepatoma Res | Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma. | 2020 | Details |
| A06971 | 32683094 | Ann Hepatol | Cerebral hemodynamics in the non-alcoholic fatty liver. | 2020 | Details |
| A06972 | 32682086 | Ann Hepatol | Hepatic transcriptome signature correlated with HOMA-IR explains early nonalcoholic fatty liver disease pathogenesis. | 2020 | Details |
| A06975 | 32680977 | Aging (Albany NY) | Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK/PPARγ pathway. | 2020 | Details |
| A06976 | 32679761 | Biomolecules | Untargeted Profiling of Bile Acids and Lysophospholipids Identifies the Lipid Signature Associated with Glycemic Outcome in an Obese Non-Diabetic Clinical Cohort. | 2020 | Details |
| A06977 | 32679195 | Arch Biochem Biophys | (-)-Epicatechin and the comorbidities of obesity. | 2020 | Details |
| A06978 | 32679144 | Life Sci | Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease. | 2020 | Details |
| A06996 | 32666969 | Food Funct | Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. | 2020 | Details |
| A06999 | 32666604 | FASEB J | Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. | 2020 | Details |
| A07001 | 32664383 | Antioxidants (Basel) | The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications. | 2020 | Details |
| A07004 | 32663612 | Ann Hepatol | Mediterranean-like mix of fatty acids induces cellular protection on lipid-overloaded hepatocytes from western diet fed mice. | 2020 | Details |
| A07015 | 32657010 | Obesity (Silver Spring) | Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. | 2020 | Details |
| A07016 | 32655764 | Oxid Med Cell Longev | Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation. | 2020 | Details |
| A07022 | 32654591 | Biosci Biotechnol Biochem | Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid. | 2020 | Details |
| A07033 | 32650421 | Cells | Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07034 | 32650222 | Nutr Res | Distinct utilization of biotin in and between adipose and brain during aging is associated with a lipogenic shift in Wistar rat brain. | 2020 | Details |
| A07040 | 32647367 | Eur J Clin Nutr | The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. | 2020 | Details |
| A07050 | 32641615 | J Oleo Sci | Basil Essential Oil and Its Nanoemulsion Mitigate Non Alcoholic Steatohepatitis in Rat Model with Special Reference to Gut Microbiota. | 2020 | Details |
| A07051 | 32640454 | Pharmacology | Molecular Study on the Potential Protective Effects of Bee Venom against Fructose-Induced Nonalcoholic Steatohepatitis in Rats. | 2020 | Details |
| A07059 | 32638492 | Aging Cell | Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. | 2020 | Details |
| A07060 | 32638417 | Aliment Pharmacol Ther | Review article: the impact of liver-directed therapies on the atherogenic risk profile in non-alcoholic steatohepatitis. | 2020 | Details |
| A07073 | 32631515 | Bioorg Med Chem Lett | Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. | 2020 | Details |
| A07078 | 32630596 | Int J Mol Sci | SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway. | 2020 | Details |
| A07095 | 32623698 | Cell Biol Toxicol | Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ. | 2020 | Details |
| A07099 | 32622843 | Metabolism | Defects in High Density Lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of Hepatocyte Nuclear Factor 4A. | 2020 | Details |
| A07101 | 32622088 | Biochim Biophys Acta Mol Cell Biol Lipids | The "discovery" of lipid droplets: A brief history of organelles hidden in plain sight. | 2020 | Details |
| A07107 | 32621046 | Cardiovasc Drugs Ther | Prolonged-release pirfenidone prevents obesity-induced cardiac steatosis and fibrosis in a mouse NASH model. | 2021 | Details |
| A07109 | 32620521 | Dig Liver Dis | Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration. | 2020 | Details |
| A07116 | 32617026 | Hepat Med | Effect of Oral Administration of Weissella confusa on Fecal and Plasma Ethanol Concentrations, Lipids and Glucose Metabolism in Wistar Rats Fed High Fructose and Fat Diet. | 2020 | Details |
| A07121 | 32614078 | J Food Sci | Relationship between structure and efficacy of sea cucumber saponins echinoside A and its derivatives on hemolytic activity and prevention of nonalcoholic fatty liver disease. | 2020 | Details |
| A07133 | 32607888 | Methods Mol Biol | In Vivo Investigation of High-Fat Diet-Induced Hepatic Lipid Dysfunctions. | 2020 | Details |
| A07152 | 32598715 | Ter Arkh | [Evaluation of the effectiveness of differentiated therapy of non-alcoholic fatty liver disease]. | 2020 | Details |
| A07171 | 32593710 | Life Sci | Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: Role of endoplasmic reticulum stress and fibrogenic pathways. | 2020 | Details |
| A07196 | 32586422 | Reprod Fertil Dev | Ovulation mitigates fatty liver associated with reproductive suppression and oxidative stress in Damaraland mole-rats (Fukomys damarensis). | 2020 | Details |
| A07197 | 32586350 | BMC Genomics | Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease. | 2020 | Details |
| A07199 | 32585242 | Life Sci | IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. | 2020 | Details |
| A07212 | 32580141 | EBioMedicine | Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans. | 2020 | Details |
| A07213 | 32579995 | Toxicol Lett | Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease. | 2020 | Details |
| A07215 | 32579743 | Mol Nutr Food Res | Fat-Shaped Microbiota Affects Lipid Metabolism, Liver Steatosis, and Intestinal Homeostasis in Mice Fed a Low-Protein Diet. | 2020 | Details |
| A07223 | 32576050 | Gut Microbes | Sex-specific maternal calcium requirements for the prevention of nonalcoholic fatty liver disease by altering the intestinal microbiota and lipid metabolism in the high-fat-diet-fed offspring mice. | 2020 | Details |
| A07224 | 32576036 | Endocr Pract | ROLE OF ANDROGEN IN LIVER FAT CONTENT IN WOMEN: METABOLICALLY ADVANTAGEOUS OR DISADVANTAGEOUS? | 2020 | Details |
| A07225 | 32575640 | Molecules | Effect of Carotenoids from Phaeodactylum tricornutum on Palmitate-Treated HepG2 Cells. | 2020 | Details |
| A07229 | 32573635 | Food Funct | Studying the effects of sea cucumber ovum powder on nonalcoholic fatty liver disease by proteomics techniques in a rat model. | 2020 | Details |
| A07230 | 32573567 | Food Funct | Bifidobacterium adolescentis and Lactobacillus rhamnosus alleviate non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet through modulation of different gut microbiota-dependent pathways. | 2020 | Details |
| A07251 | 32566547 | Can J Gastroenterol Hepatol | Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model. | 2020 | Details |
| A07260 | 32562818 | Pharmacol Res | ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis. | 2020 | Details |
| A07261 | 32562600 | Immunity | Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis. | 2020 | Details |
| A07266 | 32561790 | Sci Rep | The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07278 | 32557804 | Hepatology | Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation. | 2021 | Details |
| A07287 | 32554245 | Biomed Pharmacother | 1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. | 2020 | Details |
| A07298 | 32550887 | Exp Ther Med | Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity. | 2020 | Details |
| A07304 | 32546802 | Sci Rep | Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A07305 | 32546794 | Nat Commun | Hepatic HuR modulates lipid homeostasis in response to high-fat diet. | 2020 | Details |
| A07311 | 32544504 | Eur J Pharmacol | Vitexin ameliorates chronic stress plub high fat diet-induced nonalcoholic fatty liver disease by inhibiting inflammation. | 2020 | Details |
| A07328 | 32535386 | Biomed Pharmacother | HCBP6 deficiency exacerbates glucose and lipid metabolism disorders in non-alcoholic fatty liver mice. | 2020 | Details |
| A07340 | 32531370 | Int J Biol Macromol | The protective effects of walnut green husk polysaccharide on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in high fructose-induced mice. | 2020 | Details |
| A07348 | 32529694 | Mol Nutr Food Res | Resveratrol Alleviates Endoplasmic Reticulum Stress-Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin. | 2020 | Details |
| A07352 | 32528465 | Front Immunol | Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD. | 2020 | Details |
| A07353 | 32527258 | Lipids Health Dis | Lipoprotein A, combined with alanine aminotransferase and aspartate aminotransferase, contributes to predicting the occurrence of NASH: a cross-sectional study. | 2020 | Details |
| A07361 | 32526482 | Cell Mol Gastroenterol Hepatol | Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07367 | 32524150 | Naunyn Schmiedebergs Arch Pharmacol | Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin/CMKLR1 signalling pathway and Treg/Th17 ratio. | 2020 | Details |
| A07375 | 32522273 | Trials | Traditional Chinese medicine Lingguizhugan decoction treating non-alcoholic fatty liver disease with spleen-yang deficiency pattern: Study protocol for a multicenter randomized controlled trial. | 2020 | Details |
| A07378 | 32521450 | Biomed Pharmacother | Chinese herbal medicine mixture 919 syrup alleviates nonalcoholic fatty liver disease in rats by inhibiting the NF-κB pathway. | 2020 | Details |
| A07381 | 32519629 | J Dev Orig Health Dis | Hepatic lipid metabolism in adult rats using early weaning models: sex-related differences. | 2020 | Details |
| A07406 | 32513303 | Stem Cell Res Ther | Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy. | 2020 | Details |
| A07408 | 32512581 | PLoS One | Polysaccharides isolated from Cordyceps Sinensis contribute to the progression of NASH by modifying the gut microbiota in mice fed a high-fat diet. | 2020 | Details |
| A07424 | 32505776 | Clin Chim Acta | Intestinal microbiota-farnesoid X receptor axis in metabolic diseases. | 2020 | Details |
| A07428 | 32503411 | Mol Med | The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD). | 2020 | Details |
| A07430 | 32502637 | Pharmacol Res | Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies. | 2020 | Details |
| A07460 | 32486341 | Cancers (Basel) | Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma. | 2020 | Details |
| A07475 | 32481590 | Cells | Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation. | 2020 | Details |
| A07481 | 32477116 | Front Pharmacol | Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application. | 2020 | Details |
| A07486 | 32476787 | World J Gastroenterol | Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. | 2020 | Details |
| A07487 | 32476782 | World J Gastroenterol | Natural products that target macrophages in treating non-alcoholic steatohepatitis. | 2020 | Details |
| A07493 | 32475638 | Biochem Biophys Res Commun | Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice. | 2020 | Details |
| A07495 | 32475129 | Am J Physiol Gastrointest Liver Physiol | Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease. | 2020 | Details |
| A07496 | 32473093 | Mol Cell | Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. | 2020 | Details |
| A07508 | 32466275 | Nutrients | Blackcurrant (Ribes nigrum) Extract Prevents Dyslipidemia and Hepatic Steatosis in Ovariectomized Rats. | 2020 | Details |
| A07511 | 32463334 | Am J Physiol Gastrointest Liver Physiol | Lipid droplets disrupt mechanosensing in human hepatocytes. | 2020 | Details |
| A07515 | 32461046 | Clin Chim Acta | Emerging role of Insig-1 in lipid metabolism and lipid disorders. | 2020 | Details |
| A07520 | 32460375 | J Food Sci | Effects of polar compounds in fried palm oil on liver lipid metabolism in C57 mice. | 2020 | Details |
| A07521 | 32460191 | Biomed Pharmacother | Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats. | 2020 | Details |
| A07525 | 32455208 | ACS Omega | Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats. | 2020 | Details |