Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A25845 | 21401612 | J Pharm Pharmacol | Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis. | 2011 | Details |
| A25868 | 21374988 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | [Influence of genipin and vitamin E on UCP2 and other correlation factors in non-alcoholic fatty liver disease]. | 2010 | Details |
| A25884 | 21354232 | J Hepatol | Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. | 2011 | Details |
| A25888 | 21351214 | Inflamm Bowel Dis | Changing shape of disease: nonalcoholic fatty liver disease in Crohn's disease-a case series and review of the literature. | 2011 | Details |
| A25897 | 21346097 | J Nutr | PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. | 2011 | Details |
| A25925 | 21320636 | Int Immunopharmacol | Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. | 2011 | Details |
| A25961 | 21261727 | J Gastroenterol Hepatol | Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model. | 2011 | Details |
| A25976 | 21246004 | World J Gastroenterol | Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. | 2011 | Details |
| A25988 | 21233280 | Am J Physiol Gastrointest Liver Physiol | Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. | 2011 | Details |
| A25991 | 21228496 | J Nutr Sci Vitaminol (Tokyo) | Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD). | 2010 | Details |
| A26004 | 21218508 | Diabetes Metab Res Rev | Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia. | 2011 | Details |
| A26027 | 21190824 | J Nutr Biochem | A mouse model for nonalcoholic steatohepatitis. | 2010 | Details |
| A26038 | 21180596 | Therap Adv Gastroenterol | Treatment options for nonalcoholic fatty liver disease. | 2010 | Details |
| A26044 | 21168460 | J Hepatol | Early interplay of intra-hepatic iron and insulin resistance in children with non-alcoholic fatty liver disease. | 2010 | Details |
| A26056 | 21157426 | Int J Obes (Lond) | Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism. | 2010 | Details |
| A26061 | 21150132 | Drug Metab Pharmacokinet | Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress. | 2010 | Details |
| A26123 | 21057163 | Ann Hepatol | G308A polymorphism of TNF-alpha gene is associated with insulin resistance and histological changes in non alcoholic fatty liver disease patients. | 2011 | Details |
| A26128 | 21054517 | J Gastroenterol Hepatol | Sophocarpine alleviates non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A26169 | 20965162 | Eur J Pharmacol | The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats. | 2010 | Details |
| A26173 | 20960378 | Semin Liver Dis | Novel insights into the pathophysiology of nonalcoholic fatty liver disease. | 2010 | Details |
| A26182 | 20943080 | Zhonghua Gan Zang Bing Za Zhi | [The role of heme oxygenase-1 in non-alcoholic steatohepatitis]. | 2010 | Details |
| A26184 | 20942739 | Scand J Clin Lab Invest | Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease. | 2010 | Details |
| A26199 | 20923528 | J Diabetes | Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance. | 2009 | Details |
| A26208 | 20887718 | Clin Chim Acta | Pro-inflammatory and atherogenic circulating factors in non-alcoholic fatty liver disease associated to metabolic syndrome. | 2010 | Details |
| A26240 | 20847296 | J Lipid Res | Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice. | 2010 | Details |
| A26275 | 20801631 | J Nutr Biochem | An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. | 2010 | Details |
| A26276 | 20801629 | J Nutr Biochem | Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice. | 2010 | Details |
| A26290 | 20720266 | Ann Hepatol | Visceral adipose tissue visfatin in nonalcoholic fatty liver disease. | 2010 | Details |
| A26298 | 20687969 | Br J Nutr | The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. | 2010 | Details |
| A26318 | 20655714 | J Nutr Biochem | Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. | 2010 | Details |
| A26319 | 20655124 | J Hepatol | Down-regulation of SREBP-1c is associated with the development of burned-out NASH. | 2010 | Details |
| A26321 | 20653983 | Lipids Health Dis | Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats. | 2010 | Details |
| A26342 | 20625647 | Arq Bras Endocrinol Metabol | Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus. | 2010 | Details |
| A26369 | 20579864 | J Nutr Biochem | Serum adipocyte-specific fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects. | 2010 | Details |
| A26380 | 20560816 | Scand J Gastroenterol | A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis. | 2010 | Details |
| A26403 | 20509914 | BMC Gastroenterol | Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | 2010 | Details |
| A26417 | 20492333 | J Gastroenterol Hepatol | Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. | 2010 | Details |
| A26426 | 20473736 | Chin J Integr Med | Effect of Xuezhikang Capsule on serum tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia. | 2010 | Details |
| A26430 | 20471811 | Exp Toxicol Pathol | Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. | 2010 | Details |
| A26434 | 20462650 | J Hepatol | Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice. | 2010 | Details |
| A26450 | 20460908 | Dig Dis | The role of cytokines in non-alcoholic fatty liver disease. | 2010 | Details |
| A26466 | 20435456 | J Nutr Biochem | Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. | 2011 | Details |
| A26480 | 20413174 | J Hepatol | Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. | 2010 | Details |
| A26488 | 20402835 | J Dig Dis | Dynamic expression of hepatic thioredoxin mRNA in rats with non-alcoholic fatty liver disease. | 2010 | Details |
| A26490 | 20400911 | J Pediatr Gastroenterol Nutr | Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. | 2010 | Details |
| A26513 | 20371430 | Adv Med Sci | Tumor necrosis factor alpha and its soluble receptors in obese children with NAFLD. | 2010 | Details |
| A26520 | 20370672 | Curr Pharm Des | Pre-B cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disorders. | 2010 | Details |
| A26522 | 20370670 | Curr Pharm Des | Retinol-binding protein 4 and new adipocytokines in nonalcoholic fatty liver disease. | 2010 | Details |
| A26553 | 20216561 | Eur J Clin Nutr | Dietary and physical activity patterns in children with fatty liver. | 2010 | Details |
| A26575 | 20182586 | Am J Transl Res | Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells. | 2010 | Details |
| A26593 | 20138495 | J Nutr Biochem | Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis. | 2010 | Details |
| A26615 | 20088867 | Liver Int | The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. | 2010 | Details |
| A26636 | 20043871 | Biochem Biophys Res Commun | Tumor necrosis factor-alpha accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease. | 2009 | Details |
| A26682 | 19958640 | Zhonghua Gan Zang Bing Za Zhi | [Role of JNK signal transduction pathway in nonalcoholic fatty liver disease]. | 2009 | Details |
| A26704 | 19929783 | Curr Med Chem | Branched-chain amino acids and pigment epithelium-derived factor: novel therapeutic agents for hepatitis c virus-associated insulin resistance. | 2009 | Details |
| A26713 | 19914374 | Free Radic Biol Med | Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. | 2009 | Details |
| A26782 | 19793175 | J Gastroenterol Hepatol | Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice. | 2009 | Details |
| A26784 | 19788607 | J Gastroenterol Hepatol | Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. | 2009 | Details |
| A26802 | 19753129 | Mediators Inflamm | Adipokines in nonalcoholic steatohepatitis: from pathogenesis to implications in diagnosis and therapy. | 2009 | Details |
| A26822 | 19713474 | Am J Physiol Gastrointest Liver Physiol | Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. | 2009 | Details |
| A26824 | 19710104 | Innate Immun | Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis. | 2009 | Details |
| A26852 | 19651758 | Drug Metab Dispos | Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. | 2009 | Details |
| A26856 | 19637776 | Acta Gastroenterol Belg | Tumor necrosis factor--alpha gene promoter polymorphisms in Chinese patients with nonalcoholic fatty liver diseases. | 2009 | Details |
| A26859 | 19637282 | Hepatology | Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. | 2009 | Details |
| A26861 | 19629467 | Immunogenetics | sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. | 2009 | Details |
| A26863 | 19626358 | Eur J Nutr | Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. | 2009 | Details |
| A26870 | 19609863 | Histol Histopathol | Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD). | 2009 | Details |
| A26961 | 19459046 | Dig Dis Sci | Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats. | 2009 | Details |
| A26967 | 19446916 | J Hepatol | Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. | 2009 | Details |
| A26981 | 19416647 | Biochim Biophys Acta | Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of d-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet. | 2009 | Details |
| A27000 | 19370776 | World J Gastroenterol | Olive oil consumption and non-alcoholic fatty liver disease. | 2009 | Details |
| A27009 | 19360015 | Obesity (Silver Spring) | Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. | 2009 | Details |
| A27013 | 19355912 | Curr Mol Med | Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. | 2009 | Details |
| A27023 | 21495339 | Rev Med Chir Soc Med Nat Iasi | [Adipocytokines and nonalcoholic steatohepatitis]. | 2011 | Details |
| A27027 | 19321579 | J Nutr | Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. | 2009 | Details |
| A27067 | 19226377 | J Gastroenterol Hepatol | Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. | 2008 | Details |
| A27137 | 19115316 | Hepatology | VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. | 2009 | Details |
| A27140 | 19105201 | Hepatology | Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. | 2009 | Details |
| A27165 | 19056644 | J Nutr | Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. | 2008 | Details |
| A27175 | 19034968 | World J Gastroenterol | Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. | 2008 | Details |
| A27222 | 18956292 | Semin Liver Dis | Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. | 2008 | Details |
| A27245 | 18852641 | J Pediatr Gastroenterol Nutr | Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. | 2008 | Details |
| A27256 | 18823438 | J Gastroenterol Hepatol | Marked elevation of serum mitochondrion-derived markers in mild models of non-alcoholic steatohepatitis in rats. | 2008 | Details |
| A27273 | 18782455 | BMC Gastroenterol | Resveratrol inhibits nonalcoholic fatty liver disease in rats. | 2008 | Details |
| A27288 | 18752326 | Hepatology | Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. | 2008 | Details |
| A27296 | 18710430 | Liver Int | Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation. | 2008 | Details |
| A27313 | 18664346 | Zhong Xi Yi Jie He Xue Bao | [Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial]. | 2008 | Details |
| A27320 | 18648737 | J Gastroenterol | Liver diseases and metabolic syndrome. | 2008 | Details |
| A27357 | 18565022 | J Gastroenterol Hepatol | Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people. | 2008 | Details |
| A27384 | 18501344 | Eur J Pharmacol | Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. | 2008 | Details |
| A27399 | 18469261 | Am J Clin Nutr | Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. | 2008 | Details |
| A27410 | 18445359 | Curr Diab Rep | Genes and nonalcoholic fatty liver disease. | 2008 | Details |
| A27416 | 18422963 | J Gastroenterol Hepatol | Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis. | 2008 | Details |
| A27418 | 18421281 | Obesity (Silver Spring) | Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. | 2008 | Details |
| A27459 | 18346305 | Br J Nutr | Dietary single cell protein reduces fatty liver in obese Zucker rats. | 2008 | Details |
| A27485 | 18302012 | Inflammation | Effects of traditional chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis. | 2008 | Details |
| A27502 | 18251167 | Hepatogastroenterology | Risk factors associated with non-alcoholic fatty liver disease in Chinese patients and the role of tumor necrosis factor-alpha. | 2008 | Details |
| A27509 | 18239590 | Obesity (Silver Spring) | ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats. | 2007 | Details |
| A27522 | 18198478 | J Toxicol Sci | Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. | 2007 | Details |
| A27537 | 18171348 | J Gastroenterol Hepatol | PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. | 2008 | Details |