Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A07531 | 32454173 | J Ethnopharmacol | An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity. | 2020 | Details |
| A07542 | 32450149 | Gastroenterology | Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122. | 2020 | Details |
| A07548 | 32446270 | Br J Pharmacol | Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway. | 2020 | Details |
| A07552 | 32445754 | Toxicol Appl Pharmacol | Adipose tissue-liver crosstalk during pathologic changes caused by vinyl chloride metabolites in mice. | 2020 | Details |
| A07556 | 32444289 | Semin Cell Dev Biol | Hepatic lipid droplet homeostasis and fatty liver disease. | 2020 | Details |
| A07559 | 32443660 | Nutrients | Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. | 2020 | Details |
| A07560 | 32443556 | Nutrients | Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice. | 2020 | Details |
| A07574 | 32439267 | Clin Nutr | Theaphenon E prevents fatty liver disease and increases CD4+ T cell survival in mice fed a high-fat diet. | 2020 | Details |
| A07588 | 32434697 | Transl Res | Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis. | 2020 | Details |
| A07600 | 32429478 | Cells | Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH. | 2020 | Details |
| A07613 | 32420361 | Biomed Res Int | Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation. | 2020 | Details |
| A07617 | 32419060 | Biochem Genet | Suppression of miR-30a-3p Attenuates Hepatic Steatosis in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A07620 | 32417373 | Life Sci | CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A07647 | 32410294 | J Cell Mol Med | Magnesium isoglycyrrhizinate prevents the nonalcoholic hepatic steatosis via regulating energy homeostasis. | 2020 | Details |
| A07652 | 32408171 | iScience | High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation. | 2020 | Details |
| A07655 | 32407372 | PLoS One | Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice. | 2020 | Details |
| A07664 | 32404278 | Biochim Biophys Acta Mol Cell Biol Lipids | Niacin increases diet-induced hepatic steatosis in B6129 mice. | 2020 | Details |
| A07669 | 32401929 | Braz J Med Biol Res | A Brazilian regional basic diet-induced chronic malnutrition drives liver inflammation with higher ApoA-I activity in C57BL6J mice. | 2020 | Details |
| A07676 | 32396530 | J Clin Invest | Nonalcoholic fatty liver disease in CLOCK mutant mice. | 2020 | Details |
| A07690 | 32390388 | Clin Lab | Plasma miR-513a-5p as a Potential Biomarker for Diagnosis of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients. | 2020 | Details |
| A07695 | 32389004 | Ann Palliat Med | Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate excessive TG accumulation in hepatocytes. | 2020 | Details |
| A07696 | 32388251 | J Nutr Biochem | Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane. | 2020 | Details |
| A07697 | 32388250 | J Nutr Biochem | Targeting the gut microbiota with resveratrol: a demonstration of novel evidence for the management of hepatic steatosis. | 2020 | Details |
| A07698 | 32387861 | Biomed Pharmacother | 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. | 2020 | Details |
| A07703 | 32385406 | Sci Rep | Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. | 2020 | Details |
| A07704 | 32384593 | Nutrients | Beyond Body Weight-Loss: Dietary Strategies Targeting Intrahepatic Fat in NAFLD. | 2020 | Details |
| A07706 | 32383865 | J Agric Food Chem | Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet. | 2020 | Details |
| A07714 | 32380876 | J Med Food | Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07719 | 32376415 | J Hepatol | Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. | 2020 | Details |
| A07739 | 32369776 | J Endocrinol | Oxygen therapy alleviates hepatic steatosis by inhibiting hypoxia-inducible factor-2α. | 2020 | Details |
| A07746 | 32366600 | J Pharmacol Exp Ther | Ezetimibe Markedly Reduces Hepatic Triglycerides and Cholesterol in Rats Fed on Fish Oil by Increasing the Expression of Cholesterol Efflux Transporters. | 2020 | Details |
| A07793 | 32353385 | Toxicol Appl Pharmacol | Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. | 2020 | Details |
| A07822 | 32344934 | J Clin Med | Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial. | 2020 | Details |
| A07836 | 32339374 | Liver Int | Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD. | 2020 | Details |
| A07861 | 32331258 | Nutrients | Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07864 | 32330603 | J Hepatol | Epitranscriptomics in liver disease: Basic concepts and therapeutic potential. | 2020 | Details |
| A07870 | 32329085 | Hepatology | The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. | 2020 | Details |
| A07881 | 32324591 | Aging (Albany NY) | Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy. | 2020 | Details |
| A07906 | 32315893 | Nutr Res | Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity. | 2020 | Details |
| A07907 | 32315005 | Food Funct | Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms. | 2020 | Details |
| A07909 | 32314395 | Lipids | High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice. | 2020 | Details |
| A07920 | 32309365 | Ann Transl Med | Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation. | 2020 | Details |
| A07936 | 32305523 | Life Sci | Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A07938 | 32304952 | Environ Pollut | Exposure to 2,3,3',4,4',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice. | 2020 | Details |
| A07955 | 32300166 | Sci Rep | Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity. | 2020 | Details |
| A07958 | 32299444 | Lipids Health Dis | MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line. | 2020 | Details |
| A07961 | 32298755 | Mol Cell Endocrinol | The offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease. | 2020 | Details |
| A07964 | 32297339 | Hepatology | Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation. | 2020 | Details |
| A07966 | 32296880 | J Mol Med (Berl) | HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD. | 2020 | Details |
| A07969 | 32294235 | Eur J Clin Invest | Macrophages in the pathophysiology of NAFLD: The role of sex differences. | 2020 | Details |
| A07974 | 32292967 | Food Funct | DHA substitution overcomes high-fat diet-induced disturbance in the circadian rhythm of lipid metabolism. | 2020 | Details |
| A07980 | 32290942 | Wei Sheng Yan Jiu | [Effects of lycopene on metabolism of glycolipid and inflammation in non-alcoholic fatty liver disease rats]. | 2020 | Details |
| A07981 | 32290895 | J Dev Orig Health Dis | Excessive early-life cholesterol exposure may have later-life consequences for nonalcoholic fatty liver disease. | 2020 | Details |
| A07982 | 32290656 | J Agric Food Chem | Zinc Supplementation Alleviates Lipid and Glucose Metabolic Disorders Induced by a High-Fat Diet. | 2020 | Details |
| A07984 | 32290381 | Int J Environ Res Public Health | Sex Hormone-Dependent Physiology and Diseases of Liver. | 2020 | Details |
| A07985 | 32289885 | Cell Biochem Funct | Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice. | 2020 | Details |
| A07987 | 32289432 | Life Sci | High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. | 2020 | Details |
| A07993 | 32285676 | J Med Chem | Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07996 | 32284046 | Lipids Health Dis | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease. | 2020 | Details |
| A07997 | 32284043 | Lipids Health Dis | Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. | 2020 | Details |
| A08000 | 32283406 | Environ Pollut | Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. | 2020 | Details |
| A08002 | 32283070 | Chem Biol Interact | Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor. | 2020 | Details |
| A08004 | 32282030 | Br Med Bull | Obeticholic acid-a new therapy in PBC and NASH. | 2020 | Details |
| A08017 | 32279997 | Biochem Biophys Res Commun | Potential use of C-phycocyanin in non-alcoholic fatty liver disease. | 2020 | Details |
| A08018 | 32279995 | Biochem Biophys Res Commun | LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. | 2020 | Details |
| A08038 | 32272865 | Adipocyte | MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice. | 2020 | Details |
| A08041 | 32272794 | Animals (Basel) | Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry. | 2020 | Details |
| A08055 | 32267269 | Food Funct | A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice. | 2020 | Details |
| A08059 | 32265720 | Front Pharmacol | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. | 2020 | Details |
| A08075 | 32257815 | Mol Genet Metab Rep | Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. | 2020 | Details |
| A08085 | 32253259 | Gut | LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover. | 2020 | Details |
| A08088 | 32252024 | J Endocrinol | miR-188 promotes liver steatosis and insulin resistance via the autophagy pathway. | 2020 | Details |
| A08091 | 32250592 | Anal Chem | Double Derivatization Strategy for High-Sensitivity and High-Coverage Localization of Double Bonds in Free Fatty Acids by Mass Spectrometry. | 2020 | Details |
| A08092 | 32250344 | J Clin Invest | Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. | 2020 | Details |
| A08096 | 32246926 | Exp Mol Pathol | Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model. | 2020 | Details |
| A08101 | 32245586 | Chin J Nat Med | Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice. | 2020 | Details |
| A08102 | 32245585 | Chin J Nat Med | Fatty liver diseases, mechanisms, and potential therapeutic plant medicines. | 2020 | Details |
| A08107 | 32244304 | Cells | Role and Mechanisms of Mitophagy in Liver Diseases. | 2020 | Details |
| A08108 | 32244266 | Int J Mol Sci | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. | 2020 | Details |
| A08114 | 32242391 | J Tradit Chin Med | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B / pyrin domain-containing protein 3 pathway. | 2020 | Details |
| A08116 | 32240928 | Phytomedicine | Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense. | 2020 | Details |
| A08125 | 32239031 | Chem Commun (Camb) | Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD). | 2020 | Details |
| A08138 | 32231762 | World J Hepatol | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. | 2020 | Details |
| A08145 | 32229588 | J Lipid Res | The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. | 2020 | Details |
| A08149 | 32228319 | Am J Physiol Endocrinol Metab | Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease. | 2020 | Details |
| A08150 | 32228300 | Gut Microbes | Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood. | 2020 | Details |
| A08151 | 32226996 | Food Funct | The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet. | 2020 | Details |
| A08171 | 32219261 | Food Funct | The protective mechanisms of macroalgae Laminaria japonica consumption against lipid metabolism disorders in high-fat diet-induced hyperlipidemic rats. | 2020 | Details |
| A08181 | 32217100 | Biochem Pharmacol | Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin. | 2020 | Details |
| A08192 | 32212193 | Cell Biochem Funct | Knockdown of long non-coding RNA Gm10804 suppresses disorders of hepatic glucose and lipid metabolism in diabetes with non-alcoholic fatty liver disease. | 2020 | Details |
| A08205 | 32205994 | World J Gastroenterol | Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism. | 2020 | Details |
| A08207 | 32205261 | J Ethnopharmacol | Schaftoside alleviates HFD-induced hepatic lipid accumulation in mice via upregulating farnesoid X receptor. | 2020 | Details |
| A08223 | 32194141 | Immunol Lett | MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. | 2020 | Details |
| A08228 | 32192487 | Cell Commun Signal | FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced lipotoxicity. | 2020 | Details |
| A08231 | 32192216 | Int J Mol Sci | PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. | 2020 | Details |
| A08243 | 32190149 | Arch Med Sci | Identification of key pathways and genes in nonalcoholic fatty liver disease using bioinformatics analysis. | 2020 | Details |
| A08253 | 32187572 | Environ Int | Long-term environmental exposure to microcystins increases the risk of nonalcoholic fatty liver disease in humans: A combined fisher-based investigation and murine model study. | 2020 | Details |
| A08256 | 32185691 | Indian J Gastroenterol | The predictive value of the hepatorenal index for detection of impaired glucose metabolism in patients with non-alcoholic fatty liver disease. | 2020 | Details |
| A08260 | 32184638 | Diabetes Metab Syndr Obes | Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study. | 2020 | Details |
| A08264 | 32181656 | J Agric Food Chem | Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1. | 2020 | Details |