Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A17382 | 27813192 | Clin Exp Pharmacol Physiol | Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. | 2017 | Details |
| A17397 | 27636730 | Nat Rev Endocrinol | PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. | 2016 | Details |
| A17399 | 27806304 | Cell Rep | Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. | 2016 | Details |
| A17429 | 27788706 | Zhonghua Gan Zang Bing Za Zhi | [Effects of celecoxib on expression of PPARγ and NF-κB in type 2 diabetes rats with non-alcoholic steatohepatitis]. | 2016 | Details |
| A17442 | 27784782 | J Biol Chem | Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17445 | 27653239 | Hepatol Res | Rosuvastatin limits the activation of hepatic stellate cells in diet-induced obese mice. | 2016 | Details |
| A17471 | 27773935 | Acta Pharmacol Sin | Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. | 2016 | Details |
| A17481 | 27490779 | Biomed Pharmacother | Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. | 2016 | Details |
| A17488 | 27768909 | J Nutr Biochem | High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. | 2016 | Details |
| A17491 | 27765690 | Gastroenterology | Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes. | 2016 | Details |
| A17503 | 27267260 | Br Poult Sci | Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens. | 2016 | Details |
| A17506 | 27098507 | Diabetes Metab J | Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice. | 2016 | Details |
| A17512 | 27762456 | Phytother Res | Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model. | 2016 | Details |
| A17518 | 27760195 | PLoS One | Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. | 2016 | Details |
| A17527 | 27738106 | J Biol Chem | Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17601 | 27723468 | J Nutr Biochem | Soy isoflavones (Glycine max) ameliorate hypertriglyceridemia and hepatic steatosis in high fat-fed ovariectomized Wistar rats (an experimental model of postmenopausal obesity). | 2016 | Details |
| A17645 | 27692168 | Med Hypotheses | Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor? | 2016 | Details |
| A17687 | 27658772 | Gastroenterology | Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. | 2016 | Details |
| A17731 | 27632923 | Nutr Res | Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. | 2016 | Details |
| A17790 | 27589792 | Nutrients | Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. | 2016 | Details |
| A17835 | 27547913 | J Gastroenterol Hepatol | Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B. | 2017 | Details |
| A17839 | 27545964 | Sci Rep | Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice. | 2016 | Details |
| A17877 | 27506745 | Metabolism | Lipid phenotypes in patients with nonalcoholic fatty liver disease. | 2016 | Details |
| A17901 | 27487733 | Food Funct | Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A17912 | 27482784 | Eur J Gastroenterol Hepatol | Prevalence of hepatic steatosis in apparently healthy medical students: a transient elastography study on the basis of a controlled attenuation parameter. | 2016 | Details |
| A17923 | 27475255 | Biochim Biophys Acta | Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice. | 2016 | Details |
| A17932 | 27470139 | Sci Rep | Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice. | 2016 | Details |
| A17936 | 27468193 | World J Gastroenterol | Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. | 2016 | Details |
| A17937 | 27466003 | Sci Rep | Characterization of long non-coding RNA transcriptome in high-energy diet induced nonalcoholic steatohepatitis minipigs. | 2016 | Details |
| A17956 | 27455252 | Int J Mol Sci | Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR). | 2016 | Details |
| A17964 | 27446914 | Front Cell Dev Biol | In vitro Modulation of the LPS-Induced Proinflammatory Profile of Hepatocytes and Macrophages- Approaches for Intervention in Obesity? | 2016 | Details |
| A17978 | 27439437 | J Proteome Res | Proteome Dynamics Reveals Pro-Inflammatory Remodeling of Plasma Proteome in a Mouse Model of NAFLD. | 2016 | Details |
| A17992 | 27431935 | Int J Mol Med | Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. | 2016 | Details |
| A18023 | 27406999 | Sci Rep | CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications. | 2016 | Details |
| A18027 | 27405060 | J Hepatol | Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors. | 2016 | Details |
| A18069 | 27372863 | Med Hypotheses | Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance. | 2016 | Details |
| A18091 | 27354540 | Physiol Rep | Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet. | 2016 | Details |
| A18105 | 27349145 | Eur J Pharmacol | Effects of the new thiazolidine derivative LPSF/GQ-02 on hepatic lipid metabolism pathways in non-alcoholic fatty liver disease (NAFLD). | 2016 | Details |
| A18108 | 27348013 | Biomolecules | Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. | 2016 | Details |
| A18164 | 27311796 | Food Chem Toxicol | NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice. | 2016 | Details |
| A18174 | 27308945 | Stem Cells Dev | Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha. | 2016 | Details |
| A18222 | 27276701 | Liver Int | Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? | 2016 | Details |
| A18232 | 27270405 | Lipids | Free Fatty Acids Increase Intracellular Lipid Accumulation and Oxidative Stress by Modulating PPARα and SREBP-1c in L-02 Cells. | 2016 | Details |
| A18247 | 27265384 | Life Sci | Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. | 2016 | Details |
| A18249 | 27264075 | Mol Cell Endocrinol | Zinc alpha2 glycoprotein alleviates palmitic acid-induced intracellular lipid accumulation in hepatocytes. | 2016 | Details |
| A18259 | 27260465 | J Nutr Biochem | A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway. | 2016 | Details |
| A18317 | 27216550 | J Cell Physiol | Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR-α Knockout Mice. | 2016 | Details |
| A18327 | 27207512 | Diabetes | Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes. | 2016 | Details |
| A18341 | 27196572 | Gut | Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism. | 2016 | Details |
| A18356 | 27184920 | Sci Rep | Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer. | 2016 | Details |
| A18362 | 27181889 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | [Roles of MicroRNA-21 in the Pathogenesis of Insulin Resistance and Diabetic Mellitus-induced Non-alcoholic Fatty Liver Disease]. | 2016 | Details |
| A18389 | 27167736 | PLoS One | Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease. | 2016 | Details |
| A18406 | 27152979 | J Med Food | Water Extract of Dolichos lablab Attenuates Hepatic Lipid Accumulation in a Cellular Nonalcoholic Fatty Liver Disease Model. | 2016 | Details |
| A18423 | 27145114 | Mol Nutr Food Res | Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obese mice. | 2016 | Details |
| A18431 | 27142736 | J Nutr Biochem | Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoE(shl) mice deficient in apolipoprotein E expression. | 2016 | Details |
| A18449 | 27128907 | Int J Mol Sci | PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease. | 2016 | Details |
| A18452 | 27125895 | AAPS J | Dual Outcomes of Rosiglitazone Treatment on Fatty Liver. | 2016 | Details |
| A18460 | 27117865 | Lipids | Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias. | 2016 | Details |
| A18538 | 27063275 | Clin Liver Dis | Emerging Therapies for Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18577 | 27051590 | BBA Clin | Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. | 2016 | Details |
| A18599 | 27040342 | Yakugaku Zasshi | [Drug-induced Nonalcoholic Steatohepatitis]. | 2016 | Details |
| A18651 | 27015186 | Medicine (Baltimore) | Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients. | 2016 | Details |
| A18654 | 27012627 | J Nutr Biochem | Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | 2016 | Details |
| A18678 | 27002005 | Gut | Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. | 2016 | Details |
| A18686 | 26997950 | Gastroenterol Res Pract | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18739 | 26977393 | Mol Metab | Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. | 2016 | Details |
| A18760 | 26965314 | Lipids Health Dis | Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review. | 2016 | Details |
| A18762 | 26962021 | Biochim Biophys Acta | Nuclear receptors and nonalcoholic fatty liver disease. | 2016 | Details |
| A18787 | 26941577 | Int J Med Sci | Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18791 | 26937141 | World J Gastroenterol | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | Details |
| A18820 | 26921863 | J Affect Disord | Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. | 2016 | Details |
| A18880 | 26889237 | Exp Ther Med | Effects of a combination of puerarin, baicalin and berberine on the expression of proliferator-activated receptor-γ and insulin receptor in a rat model of nonalcoholic fatty liver disease. | 2015 | Details |
| A18909 | 26874076 | Gastroenterology | Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. | 2016 | Details |
| A18910 | 26873633 | Biochim Biophys Acta | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Details |
| A18915 | 26871756 | Can J Physiol Pharmacol | The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. | 2015 | Details |
| A18919 | 26870934 | Semin Liver Dis | Nuclear Receptor Modulation for the Treatment of Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18940 | 26858440 | Proc Natl Acad Sci U S A | Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. | 2016 | Details |
| A18972 | 26842974 | J Chin Med Assoc | Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats. | 2016 | Details |
| A18976 | 26838599 | Gut | Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. | 2016 | Details |
| A18977 | 26838182 | Food Funct | Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice. | 2016 | Details |
| A18998 | 26826574 | Redox Biol | Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance. | 2016 | Details |
| A19001 | 26825546 | Eur J Pharmacol | Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose induced NASH in rats: Modulation of gene expression. | 2016 | Details |
| A19009 | 26820774 | Biochim Biophys Acta | Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice. | 2016 | Details |
| A19043 | 26806698 | J Pharm Pharmacol | Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice. | 2016 | Details |
| A19055 | 26797396 | Am J Physiol Gastrointest Liver Physiol | Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice. | 2016 | Details |
| A19073 | 26783552 | Cell Mol Gastroenterol Hepatol | Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. | 2015 | Details |
| A19077 | 26778339 | Clin Nutr | The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis. | 2015 | Details |
| A19078 | 26775807 | Sci Rep | Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency. | 2016 | Details |
| A19093 | 26770926 | Clin Mol Hepatol | Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study. | 2015 | Details |
| A19096 | 26770322 | Int J Clin Exp Med | Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway. | 2015 | Details |
| A19112 | 26756202 | Diabet Med | Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. | 2016 | Details |
| A19116 | 26754585 | Endocrinol Metab (Seoul) | The Relationship between 10-Year Cardiovascular Risk Calculated Using the Pooled Cohort Equation and the Severity of Non-Alcoholic Fatty Liver Disease. | 2016 | Details |
| A19117 | 26753695 | Naunyn Schmiedebergs Arch Pharmacol | Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis. | 2016 | Details |
| A19139 | 26732252 | Sci Rep | Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. | 2016 | Details |
| A19153 | 26725908 | Liver Int | Iron and the liver. | 2016 | Details |
| A19197 | 26711682 | Dig Liver Dis | Celiac disease-related hepatic injury: Insights into associated conditions and underlying pathomechanisms. | 2015 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19214 | 26698665 | Free Radic Biol Med | Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development. | 2015 | Details |
| A19223 | 26695085 | J Gastroenterol Hepatol | Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats. | 2016 | Details |
| A19235 | 26681923 | Int J Biol Sci | A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. | 2015 | Details |