Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Tumor necrosis factor1477 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A27551 | 18081738 | Aliment Pharmacol Ther | Adipokines and cytokines in non-alcoholic fatty liver disease. | 2007 | Details |
| A27560 | 18066656 | Inflammation | The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2007 | Details |
| A27561 | 18062158 | Praxis (Bern 1994) | [Non-alcoholic steatohepatitis--a new epidemic]. | 2007 | Details |
| A27565 | 18056890 | Diabetes Care | Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects. | 2007 | Details |
| A27582 | 18000721 | Obes Surg | Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A27586 | 17986629 | Am J Physiol Endocrinol Metab | Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet. | 2007 | Details |
| A27595 | 17953248 | Obes Surg | Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease. | 2007 | Details |
| A27597 | 17950097 | Metabolism | Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line. | 2007 | Details |
| A27608 | 17914984 | J Gastroenterol Hepatol | Preventive role of genistein in an experimental non-alcoholic steatohepatitis model. | 2007 | Details |
| A27641 | 17823431 | Am J Clin Nutr | Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake. | 2007 | Details |
| A27650 | 17761893 | J Endocrinol | Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. | 2007 | Details |
| A27662 | 17567459 | J Gastroenterol Hepatol | Role of mitochondria in non-alcoholic fatty liver disease. | 2007 | Details |
| A27676 | 17691915 | Curr Drug Discov Technol | Current treatment strategies for non-alcoholic fatty liver disease (NAFLD). | 2007 | Details |
| A27706 | 17608262 | Obes Surg | IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients. | 2007 | Details |
| A27757 | 17509993 | Am J Clin Pathol | Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. | 2007 | Details |
| A27774 | 17476695 | Hepatology | Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. | 2007 | Details |
| A27786 | 17452309 | Orv Hetil | [Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. | 2007 | Details |
| A27789 | 17444848 | J Gastroenterol Hepatol | Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis. | 2007 | Details |
| A27805 | 17395331 | J Hepatol | Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. | 2007 | Details |
| A27815 | 17376039 | J Gastroenterol Hepatol | Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: comprehensive study of clinical and immunohistochemical findings in younger Asian patients. | 2007 | Details |
| A27828 | 17331172 | Alcohol Clin Exp Res | Serum intercellular adhesion molecule-1 in patients with nonalcoholic steatohepatitis: comparison with alcoholic hepatitis. | 2007 | Details |
| A27841 | 17295176 | Semin Liver Dis | Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. | 2007 | Details |
| A27865 | 17210084 | BMC Cardiovasc Disord | The effects of second-hand smoke on biological processes important in atherogenesis. | 2007 | Details |
| A27870 | 17201732 | Clin Exp Pharmacol Physiol | Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease. | 2007 | Details |
| A27933 | 16958667 | J Gastroenterol Hepatol | Mitochondrial glutathione: hepatocellular survival-death switch. | 2006 | Details |
| A27956 | 16904946 | Clin Gastroenterol Hepatol | Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease. | 2006 | Details |
| A27964 | 16865780 | World J Gastroenterol | Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. | 2006 | Details |
| A27968 | 16845716 | J Zhejiang Univ Sci B | Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats. | 2006 | Details |
| A27974 | 16825325 | Gut | Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease. | 2006 | Details |
| A27984 | 16796890 | Zhonghua Yi Xue Za Zhi | [Therapeutic effects of insulin-sensitizing drugs on nonalcoholic fatty liver disease: experiment with rats]. | 2006 | Details |
| A28039 | 16624332 | Life Sci | High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. | 2006 | Details |
| A28041 | 16618517 | J Hepatol | Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. | 2006 | Details |
| A28044 | 16610015 | World J Gastroenterol | Treatment of nonalcoholic fatty liver disease. | 2006 | Details |
| A28054 | 16564703 | Cytokine | Increased production of IL-1alpha and TNF-alpha in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease. | 2006 | Details |
| A28087 | 16479931 | Zhong Yao Cai | [TNF-alpha gene expression of NAFLD rat intervened by the extracts of Rizoma Polygoni Cuspidati]. | 2005 | Details |
| A28101 | 16420507 | Liver Int | Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis. | 2006 | Details |
| A28121 | 16374858 | Hepatology | JNK1 but not JNK2 promotes the development of steatohepatitis in mice. | 2006 | Details |
| A28126 | 16356442 | J Pediatr | Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. | 2005 | Details |
| A28142 | 16270401 | World J Gastroenterol | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients? | 2005 | Details |
| A28181 | 16225467 | Aliment Pharmacol Ther | Review article: type 2 diabetes and chronic liver disease in the Verona diabetes study. | 2005 | Details |
| A28189 | 16201116 | Hepatogastroenterology | Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis. | 2005 | Details |
| A28190 | 16198624 | Hepatol Res | Lessons from animal models of NASH. | 2005 | Details |
| A28192 | 16198621 | Hepatol Res | Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases. | 2005 | Details |
| A28256 | 15942443 | J Clin Gastroenterol | Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. | 2005 | Details |
| A28282 | 15818153 | Curr Opin Gastroenterol | Alcohol and the liver. | 2005 | Details |
| A28318 | 15700216 | Z Gastroenterol | The relationship between apoptosis and non-alcoholic fatty liver disease: an evolutionary cornerstone turned pathogenic. | 2005 | Details |
| A28333 | 15623825 | J Nutr | Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. | 2005 | Details |
| A28365 | 15464239 | J Hepatol | Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. | 2004 | Details |
| A28379 | 15331067 | Clin Liver Dis | Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. | 2004 | Details |
| A28395 | 15239102 | Hepatology | Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. | 2004 | Details |
| A28396 | 15239085 | Hepatology | Beyond insulin resistance in NASH: TNF-alpha or adiponectin? | 2004 | Details |
| A28426 | 15046183 | Dig Liver Dis | Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship? | 2004 | Details |
| A28434 | 14975757 | Biochem Biophys Res Commun | Acarbose attenuates experimental non-alcoholic steatohepatitis. | 2004 | Details |
| A28481 | 12730884 | Gastroenterology | Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. | 2003 | Details |
| A28494 | 12540784 | Hepatology | Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. | 2003 | Details |
| A28515 | 12406438 | Best Pract Res Clin Gastroenterol | Pathogenesis of steatohepatitis. | 2002 | Details |
| A28548 | 11584365 | Hepatology | Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. | 2001 | Details |
| A28571 | 10418175 | Zhonghua Yi Xue Za Zhi (Taipei) | Interleukin-8 and alcoholic liver disease. | 1999 | Details |
| A28580 | 8738722 | J Hepatol | Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. | 1996 | Details |
| A28645 | 35192632 | PLoS One | Ipragliflozin attenuates non-alcoholic steatohepatitis development in an animal model. | 2022 | Details |
| A28774 | 35024320 | Acta Pharm Sin B | A small molecule UPR modulator for diabetes identified by high throughput screening. | 2021 | Details |
| A28973 | 34757037 | J Genet Genomics | Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies. | 2021 | Details |
| A29175 | 34470535 | Hum Exp Toxicol | Effect of curcumin on the non-alcoholic steatohepatitis via inhibiting the M1 polarization of macrophages. | 2021 | Details |
| A29280 | 34305946 | Front Immunol | The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. | 2021 | Details |
| A29394 | 34149876 | Exp Ther Med | Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A29494 | 33987382 | Ann Transl Med | The effects of S-nitrosylation-induced PPARγ/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis. | 2021 | Details |
| A29742 | 33590776 | Gut Microbes | The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases. | 2022 | Details |
| A29820 | 33447518 | J Clin Transl Hepatol | A 3D Human Liver Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30027 | 33102487 | Front Cell Dev Biol | Distinct Factors Secreted by Adipose Stromal Cells Protect the Endothelium From Barrier Dysfunction and Apoptosis. | 2020 | Details |
| A30453 | 32425782 | Front Pharmacol | Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats. | 2020 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A30670 | 32021639 | Nutr Metab (Lond) | Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. | 2020 | Details |
| A30701 | 31940797 | Int J Mol Sci | Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases. | 2020 | Details |
| A30893 | 31610032 | Hepatology | Yes-Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A31102 | 31222801 | Hepatology | Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | 2019 | Details |
| A31384 | 30675167 | Stem Cells Int | Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats. | 2018 | Details |
| A31662 | 30084733 | J Neurotrauma | Dietary Green Tea Extract Prior to Spinal Cord Injury Prevents Hepatic Iron Overload but Does Not Improve Chronic Hepatic and Spinal Cord Pathology in Rats. | 2018 | Details |
| A31682 | 30048033 | Hepatol Res | Homocysteine supplementation ameliorates steatohepatitis induced by a choline-deficient diet in mice. | 2018 | Details |
| A32261 | 28831287 | Evid Based Complement Alternat Med | Extracts of Salvia-Nelumbinis Naturalis Ameliorate Nonalcoholic Steatohepatitis via Inhibiting Gut-Derived Endotoxin Mediated TLR4/NF-κB Activation. | 2017 | Details |
| A32308 | 28740538 | Evid Based Complement Alternat Med | Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. | 2017 | Details |
| A32341 | 28680450 | Evid Based Complement Alternat Med | An ErChen and YinChen Decoction Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis in Rats by Regulating JNK1 Signaling Pathway. | 2017 | Details |
| A32468 | 28365916 | Dig Dis Sci | Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. | 2017 | Details |
| A32537 | 28167852 | Mediators Inflamm | Salvia-Nelumbinis Naturalis Formula Improved Inflammation in LPS Stressed Macrophages via Upregulating MicroRNA-152. | 2017 | Details |
| A32563 | 28109017 | J Gastroenterol Hepatol | Clostridium butyricum B1 alleviates high-fat diet-induced steatohepatitis in mice via enterohepatic immunoregulation. | 2017 | Details |
| A32582 | 28066964 | Hepatol Res | Mechanisms of the prevention and inhibition of the progression and development of non-alcoholic steatohepatitis by genetic and pharmacological decoy receptor 3 supplementation. | 2017 | Details |
| A32700 | 27747583 | Rheumatol Ther | Randomized Crossover Comparison of Injection Site Pain with 40 mg/0.4 or 0.8 mL Formulations of Adalimumab in Patients with Rheumatoid Arthritis. | 2016 | Details |
| A32785 | 27477940 | Gastroenterology | Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia. | 2016 | Details |
| A32838 | 27315400 | Mol Med Rep | Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. | 2016 | Details |
| A32956 | 26992446 | Hepatol Res | Non-alcoholic steatohepatitis-associated hepatic fibrosis and hepatocellular carcinoma in a combined mouse model of genetic modification and dietary challenge. | 2016 | Details |
| A33018 | 26856696 | J Neuroinflammation | Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. | 2016 | Details |
| A33049 | 26791024 | Arch Dermatol Res | Hydrogen sulfide diminishes the levels of thymic stromal lymphopoietin in activated mast cells. | 2016 | Details |
| A33232 | 26408955 | Clin Immunol | Misoprostol modulates cytokine expression through a cAMP pathway: Potential therapeutic implication for liver disease. | 2015 | Details |
| A33696 | 25385666 | Ir J Med Sci | Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect? | 2014 | Details |
| A33799 | 25132496 | Cancer Cell | ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. | 2014 | Details |
| A33818 | 25082518 | Cancer Chemother Pharmacol | Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model. | 2014 | Details |
| A33844 | 25036371 | J Neurotrauma | Spinal cord injury causes chronic liver pathology in rats. | 2014 | Details |
| A34035 | 24582082 | Dig Liver Dis | Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice. | 2014 | Details |
| A34076 | 24471744 | J Pharm Pharmacol | Bupropion effects on high-fat diet-induced steatohepatitis and endothelial dysfunction in rats: role of tumour necrosis factor-alpha. | 2014 | Details |
| A34154 | 24303091 | World J Hepatol | Increased bone mineral density in patients with non-alcoholic steatohepatitis. | 2013 | Details |
| A34197 | 24156694 | J Toxicol Environ Health A | Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions. | 2013 | Details |