Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A19249 | 26674248 | BBA Clin | Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. | 2015 | Details |
| A19258 | 26669188 | Zhen Ci Yan Jiu | [Effects of Electroacupunctrue Combined with Dietary Control on Peroxisome Proliferator-activa- ted Receptor-α, and Liver Fatty Acid-binding Protein Levels in Non-alcoholic Fatty Liver Disease Rats]. | 2015 | Details |
| A19260 | 26668503 | World J Gastroenterol | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease. | 2015 | Details |
| A19323 | 26629547 | EBioMedicine | Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals. | 2015 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19398 | 26592314 | Proc Nutr Soc | Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms. | 2015 | Details |
| A19411 | 26583037 | Nutr Metab (Lond) | High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. | 2015 | Details |
| A19433 | 26571089 | J Ethnopharmacol | Li-Gan-Shi-Liu-Ba-Wei-San improves non-alcoholic fatty liver disease through enhancing lipid oxidation and alleviating oxidation stress. | 2015 | Details |
| A19441 | 26567565 | Biochemistry (Mosc) | Molecular Mechanisms of Latent Inflammation in Metabolic Syndrome. Possible Role of Sirtuins and Peroxisome Proliferator-Activated Receptor Type γ. | 2015 | Details |
| A19491 | 26524364 | Zhonghua Gan Zang Bing Za Zhi | [Effects of fenofibrate on hepatocyte apoptosis in nonalcoholic fatty liver]. | 2015 | Details |
| A19522 | 26511621 | Cardiovasc Diabetol | Combined influence of nonalcoholic fatty liver and body size phenotypes on diabetes risk. | 2015 | Details |
| A19526 | 26509584 | Appl Physiol Nutr Metab | Aerobic interval exercise improves parameters of nonalcoholic fatty liver disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. | 2015 | Details |
| A19537 | 26502898 | Chem Biol Drug Des | Synthesis of Naphthyl-, Quinolin- and Anthracenyl Analogues of Clofibric Acid as PPARα Agonists. | 2015 | Details |
| A19562 | 26485433 | PLoS One | 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. | 2015 | Details |
| A19564 | 26483372 | Georgian Med News | [C677T AND A1298C ALLELE POLYMORPHISM GENE OF METHYLENETETRAHYDRAFOLATEREDUCTASE IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES]. | 2015 | Details |
| A19573 | 28962484 | Toxicol Rep | Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat. | 2015 | Details |
| A19579 | 26473919 | Nutrients | Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress. | 2015 | Details |
| A19608 | 26460614 | PLoS One | Nonalcoholic Fatty Liver Disease: Correlation of the Liver Parenchyma Fatty Acid with Intravoxel Incoherent Motion MR Imaging-An Experimental Study in a Rat Model. | 2015 | Details |
| A19625 | 26449539 | BMC Genomics | The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. | 2015 | Details |
| A19644 | 26441241 | Endocrinology | SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development. | 2015 | Details |
| A19647 | 26438694 | Dis Model Mech | Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats. | 2015 | Details |
| A19649 | 26438035 | BMC Complement Altern Med | Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. | 2015 | Details |
| A19679 | 26418083 | PLoS One | Diet-Quality Scores and Prevalence of Nonalcoholic Fatty Liver Disease: A Population Study Using Proton-Magnetic Resonance Spectroscopy. | 2015 | Details |
| A19741 | 26379885 | Int J Clin Exp Med | Physical training improves body weight and energy balance but does not protect against hepatic steatosis in obese mice. | 2015 | Details |
| A19758 | 26375281 | PLoS One | Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver. | 2015 | Details |
| A19769 | 26363221 | Mol Cell Endocrinol | AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1. | 2015 | Details |
| A19776 | 26356709 | Medicine (Baltimore) | Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. | 2015 | Details |
| A19780 | 26355313 | Georgian Med News | PRO12ALA POLYMORPHISM ASSOCIATION OF PPAR-γ GENE WITH BIOCHEMICAL PARAMETERS OF THE BLOOD IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES. | 2015 | Details |
| A19803 | 26340970 | Eur J Endocrinol | Increased prevalence of polycystic ovary syndrome in premenopausal women with nonalcoholic fatty liver disease. | 2015 | Details |
| A19807 | 26338827 | Gut | Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. | 2015 | Details |
| A19816 | 26330104 | Sci Rep | Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease. | 2015 | Details |
| A19833 | 26317347 | PLoS One | Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis. | 2015 | Details |
| A19872 | 26292849 | Br J Pharmacol | Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes. | 2015 | Details |
| A19927 | 26260846 | Biochim Biophys Acta | 14-3-3β and γ differentially regulate peroxisome proliferator activated receptor γ2 transactivation and hepatic lipid metabolism. | 2015 | Details |
| A19943 | 26251667 | Nutr Metab (Lond) | Exercise training improves liver steatosis in mice. | 2015 | Details |
| A19950 | 26246323 | J Nutr | Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats. | 2015 | Details |
| A19953 | 26242978 | Lipids Health Dis | Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats. | 2015 | Details |
| A19969 | 26234231 | Intern Med | Hepatocellular Carcinoma in a Patient with Polycystic Liver Disease. | 2015 | Details |
| A19981 | 26228038 | Lipids Health Dis | Effect of a high fat, high sucrose diet on the promotion of non-alcoholic fatty liver disease in male rats: the ameliorative role of three natural compounds. | 2015 | Details |
| A19991 | 26221176 | Evid Based Complement Alternat Med | Intervening TNF-α via PPARγ with Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A20041 | 26194065 | Cytokine | PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. | 2015 | Details |
| A20042 | 26193881 | Lipids Health Dis | Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice. | 2015 | Details |
| A20053 | 26190035 | Hepatol Res | Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling. | 2015 | Details |
| A20071 | 26176317 | J Agric Food Chem | Fermented Rhus verniciflua Stokes Extract Exerts an Antihepatic Lipogenic Effect in Oleic-Acid-Induced HepG2 Cells via Upregulation of AMP-Activated Protein Kinase. | 2015 | Details |
| A20100 | 26155043 | J Clin Exp Hepatol | The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20118 | 26143342 | Dig Dis Sci | Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20137 | 26133486 | Int J Mol Med | Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model. | 2015 | Details |
| A20169 | 26113985 | Open Heart | Capsaicin may have important potential for promoting vascular and metabolic health. | 2015 | Details |
| A20170 | 26113868 | Evid Based Complement Alternat Med | Effects on Liver Lipid Metabolism of the Naturally Occurring Dietary Flavone Luteolin-7-glucoside. | 2015 | Details |
| A20175 | 26108973 | Eur J Clin Invest | Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD. | 2015 | Details |
| A20177 | 26108652 | Indian J Gastroenterol | Serum ferritin levels predict histological severity in patients with nonalcoholic fatty liver disease in India. | 2015 | Details |
| A20186 | 26098879 | PLoS One | Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. | 2015 | Details |
| A20201 | 26087253 | PLoS One | Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age. | 2015 | Details |
| A20255 | 26061453 | J Med Food | Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets. | 2015 | Details |
| A20268 | 26052390 | World J Hepatol | Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease. | 2015 | Details |
| A20309 | 26035752 | Int J Mol Sci | Effect of Chronic Pioglitazone Treatment on Hepatic Gene Expression Profile in Obese C57BL/6J Mice. | 2015 | Details |
| A20321 | 28210688 | Cell Mol Gastroenterol Hepatol | Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences. | 2015 | Details |
| A20324 | 26028044 | Curr Drug Targets | Natural Products on Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A20352 | 26019041 | Ann Hepatol | Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model. | 2016 | Details |
| A20355 | 26018806 | Mol Med | Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20369 | 26008803 | Diab Vasc Dis Res | Non-alcoholic fatty liver disease associated with increased arterial stiffness in subjects with normal glucose tolerance, but not pre-diabetes and diabetes. | 2015 | Details |
| A20389 | 25998209 | Hepatology | Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. | 2015 | Details |
| A20418 | 25979856 | Eur J Pharmacol | An experimental study on amelioration of dyslipidemia-induced atherosclesis by Clematichinenoside through regulating Peroxisome proliferator-activated receptor-α mediated apolipoprotein A-I, A-II and C-III. | 2015 | Details |
| A20426 | 25974206 | Sci Rep | Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice. | 2015 | Details |
| A20430 | 25972092 | Biol Pharm Bull | Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice. | 2015 | Details |
| A20510 | 25915743 | Nutr Diabetes | Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. | 2015 | Details |
| A20536 | 25905490 | PLoS One | Higher estimated net endogenous Acid production may be associated with increased prevalence of nonalcoholic Fatty liver disease in chinese adults in Hong Kong. | 2015 | Details |
| A20545 | 25896720 | Pharmacology | Fenofibrate treatment attenuated chronic endoplasmic reticulum stress in the liver of nonalcoholic fatty liver disease mice. | 2015 | Details |
| A20546 | 25896250 | Mol Ther | Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. | 2015 | Details |
| A20564 | 25881230 | BMC Gastroenterol | Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model. | 2015 | Details |
| A20565 | 25880979 | Zhonghua Gan Zang Bing Za Zhi | [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. | 2015 | Details |
| A20604 | 25859289 | Clin Epigenetics | Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. | 2015 | Details |
| A20623 | 25848461 | World J Hepatol | Non-alcoholic fatty liver disease and psoriasis: So far, so near. | 2015 | Details |
| A20643 | 25837920 | J Pharmacol Sci | Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats. | 2014 | Details |
| A20655 | 25827944 | J Physiol Biochem | Liver delipidating effect of a combination of resveratrol and quercetin in rats fed an obesogenic diet. | 2015 | Details |
| A20671 | 25816034 | Medicine (Baltimore) | Nonalcoholic fatty liver disease as a risk factor of arterial stiffness measured by the cardioankle vascular index. | 2015 | Details |
| A20711 | 25788185 | Hepatol Int | A novel 2-step approach combining the NAFLD fibrosis score and liver stiffness measurement for predicting advanced fibrosis. | 2014 | Details |
| A20717 | 25780284 | World J Gastroenterol | Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors. | 2015 | Details |
| A20728 | 25773177 | Am J Pathol | PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation. | 2015 | Details |
| A20748 | 25757271 | Yao Xue Xue Bao | [Recent advances in curcumin and its derivatives for treatment of liver diseases]. | 2014 | Details |
| A20763 | 25748419 | Life Sci | Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice. | 2015 | Details |
| A20784 | 25736301 | Biochim Biophys Acta | Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. | 2015 | Details |
| A20810 | 25717238 | World J Gastroenterol | Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats. | 2015 | Details |
| A20832 | 25706109 | Curr Drug Targets | Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism. | 2015 | Details |
| A20835 | 25703085 | J Hepatol | PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. | 2015 | Details |
| A20838 | 25701781 | Biochem Biophys Res Commun | Protective effects of aerobic swimming training on high-fat diet induced nonalcoholic fatty liver disease: regulation of lipid metabolism via PANDER-AKT pathway. | 2015 | Details |
| A20845 | 25690590 | Curr Atheroscler Rep | FXR agonists as therapeutic agents for non-alcoholic fatty liver disease. | 2015 | Details |
| A20876 | 25671200 | J Exerc Nutrition Biochem | Effect of aerobic exercise training on non-alcoholic fatty liver disease induced by a high fat diet in C57BL/6 mice. | 2014 | Details |
| A20888 | 25661699 | Int Immunopharmacol | Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats. | 2015 | Details |
| A20920 | 25645621 | Biochim Biophys Acta | PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro. | 2015 | Details |
| A20935 | 25632188 | World J Gastroenterol | Factors associated with significant liver fibrosis assessed using transient elastography in general population. | 2015 | Details |
| A20936 | 25632182 | World J Gastroenterol | Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease. | 2015 | Details |
| A20974 | 25608776 | Ann Gastroenterol | Value of 3 Tesla diffusion-weighted magnetic resonance imaging for assessing liver fibrosis. | 2020 | Details |
| A20980 | 25605057 | Int J Mol Med | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Details |
| A20981 | 25604802 | Expert Opin Investig Drugs | Early investigational drugs targeting PPAR-α for the treatment of metabolic disease. | 2015 | Details |
| A21084 | 25544867 | Oxid Med Cell Longev | Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway. | 2014 | Details |
| A21103 | 25534988 | Biochem Pharmacol | The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet. | 2014 | Details |
| A21110 | 25533124 | Biochim Biophys Acta | Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα. | 2014 | Details |
| A21180 | 25496394 | BMC Gastroenterol | Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population. | 2014 | Details |
| A21216 | 25474087 | Int J Mol Sci | Altered fatty acid metabolism-related gene expression in liver from morbidly obese women with non-alcoholic fatty liver disease. | 2014 | Details |