Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A26189 | 20938992 | Mol Nutr Food Res | Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet. | 2010 | Details |
| A26194 | 20932147 | Expert Rev Gastroenterol Hepatol | Nonalcoholic steatohepatitis: risk factors and diagnosis. | 2010 | Details |
| A26205 | 20888662 | J Hepatol | Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. | 2010 | Details |
| A26297 | 20687985 | Acta Med Port | [Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk]. | 2010 | Details |
| A26336 | 20629985 | J Cell Mol Med | High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia. | 2010 | Details |
| A26382 | 20557969 | J Hepatol | Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. | 2010 | Details |
| A26391 | 20532833 | Obes Surg | A biomarker panel for non-alcoholic steatohepatitis (NASH) and NASH-related fibrosis. | 2011 | Details |
| A26407 | 20506389 | J Cell Biochem | ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and human nonalcoholic fatty livers. | 2010 | Details |
| A26411 | 20501438 | Am J Physiol Gastrointest Liver Physiol | Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. | 2009 | Details |
| A26419 | 20491641 | Curr Med Chem | Targeting mitochondria: a new promising approach for the treatment of liver diseases. | 2010 | Details |
| A26430 | 20471811 | Exp Toxicol Pathol | Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. | 2010 | Details |
| A26441 | 20460917 | Dig Dis | Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. | 2010 | Details |
| A26442 | 20460916 | Dig Dis | Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression. | 2010 | Details |
| A26449 | 20460909 | Dig Dis | Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases. | 2010 | Details |
| A26469 | 20432253 | Hepatology | Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats. | 2010 | Details |
| A26476 | 20416398 | Biochim Biophys Acta | Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. | 2010 | Details |
| A26486 | 20406065 | Biomark Med | Is alanine aminotransferase level a surrogate biomarker of hepatic apoptosis in nonalcoholic fatty liver disease? | 2010 | Details |
| A26496 | 20392873 | J Clin Endocrinol Metab | Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease. | 2010 | Details |
| A26517 | 20370677 | Curr Pharm Des | Insulin resistance in nonalcoholic fatty liver disease. | 2010 | Details |
| A26524 | 20368747 | Clin Lipidol | Mechanisms and clinical implications of hepatocyte lipoapoptosis. | 2010 | Details |
| A26559 | 20206399 | J Hepatol | Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. | 2010 | Details |
| A26566 | 20196952 | Zhonghua Gan Zang Bing Za Zhi | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. | 2010 | Details |
| A26574 | 20185414 | J Lipid Res | Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. | 2010 | Details |
| A26575 | 20182586 | Am J Transl Res | Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells. | 2010 | Details |
| A26608 | 20101463 | Dig Dis Sci | Nonalcoholic fatty liver disease: a review and update. | 2010 | Details |
| A26616 | 20087858 | Mol Nutr Food Res | Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. | 2010 | Details |
| A26636 | 20043871 | Biochem Biophys Res Commun | Tumor necrosis factor-alpha accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease. | 2009 | Details |
| A26648 | 21525755 | Dig Dis | Induction of cross-linking and silencing of Sp1 by transglutaminase during liver injury in ASH and NASH via different ER stress pathways. | 2011 | Details |
| A26656 | 20038265 | Immunopharmacol Immunotoxicol | Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. | 2010 | Details |
| A26699 | 19936233 | PLoS One | IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. | 2009 | Details |
| A26733 | 19881359 | J Clin Gastroenterol | Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease. | 2010 | Details |
| A26758 | 19821522 | Hepatology | Activation of the complement system in human nonalcoholic fatty liver disease. | 2009 | Details |
| A26766 | 19818306 | Clin Liver Dis | Endoplasmic reticulum stress and the unfolded protein response. | 2009 | Details |
| A26767 | 19818305 | Clin Liver Dis | Apoptosis and cytokines in non-alcoholic steatohepatitis. | 2009 | Details |
| A26768 | 19818304 | Clin Liver Dis | Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis. | 2009 | Details |
| A26793 | 19777393 | Curr Opin Investig Drugs | Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. | 2009 | Details |
| A26803 | 19752584 | Pharmacology | Prevention of free fatty acid-induced hepatic lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro. | 2009 | Details |
| A26824 | 19710104 | Innate Immun | Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis. | 2009 | Details |
| A26825 | 19702912 | J Gastroenterol Hepatol | Effect of dietary fat to produce non-alcoholic fatty liver in the rat. | 2009 | Details |
| A26839 | 19676126 | Hepatology | Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. | 2009 | Details |
| A26840 | 19673631 | Expert Rev Gastroenterol Hepatol | Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. | 2009 | Details |
| A26861 | 19629467 | Immunogenetics | sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. | 2009 | Details |
| A26885 | 19585618 | Hepatology | Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. | 2009 | Details |
| A26916 | 19381121 | Ann Hepatol | Noninvasive diagnosis of nonalcoholic fatty liver disease. | 2009 | Details |
| A26921 | 19546889 | Cell Res | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells. | 2009 | Details |
| A26946 | 19490416 | Liver Int | Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. | 2009 | Details |
| A26967 | 19446916 | J Hepatol | Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. | 2009 | Details |
| A27011 | 19359149 | Nutr Metab Cardiovasc Dis | Hepatic lipid metabolism and non-alcoholic fatty liver disease. | 2009 | Details |
| A27040 | 19290887 | FEBS J | Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase. | 2009 | Details |
| A27067 | 19226377 | J Gastroenterol Hepatol | Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. | 2008 | Details |
| A27072 | 19223251 | Dig Liver Dis | Non-alcoholic fatty liver disease pathogenesis: the present and the future. | 2009 | Details |
| A27117 | 19141695 | Am J Clin Nutr | Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. | 2009 | Details |
| A27126 | 19119140 | J Biol Chem | Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. | 2009 | Details |
| A27140 | 19105201 | Hepatology | Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. | 2009 | Details |
| A27173 | 19038040 | J Transl Med | Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign? | 2008 | Details |
| A27221 | 18956293 | Semin Liver Dis | Mechanisms of disease progression in nonalcoholic fatty liver disease. | 2008 | Details |
| A27222 | 18956292 | Semin Liver Dis | Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. | 2008 | Details |
| A27233 | 18939388 | Cleve Clin J Med | Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. | 2008 | Details |
| A27245 | 18852641 | J Pediatr Gastroenterol Nutr | Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. | 2008 | Details |
| A27267 | 18795706 | Hepatogastroenterology | Serum gamma-glutamyltranspeptidase distinguishes non-alcoholic fatty liver disease at high risk. | 2009 | Details |
| A27372 | 32038787 | Toxicol Res | Involvement of Endoplasmic Reticulum Stress in Palmitate-induced Apoptosis in HepG2 Cells. | 2008 | Details |
| A27386 | 18500507 | Obes Surg | A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). | 2008 | Details |
| A27391 | 18486983 | J Hepatol | Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. | 2008 | Details |
| A27408 | 18452708 | Biochem Biophys Res Commun | Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis. | 2008 | Details |
| A27409 | 18452148 | Hepatology | Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. | 2008 | Details |
| A27415 | 18430557 | J Nutr Biochem | The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. | 2008 | Details |
| A27428 | 18336657 | J Gastroenterol Hepatol | Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. | 2008 | Details |
| A27516 | 18218340 | Trends Mol Med | Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. | 2008 | Details |
| A27553 | 18081207 | Mol Nutr Food Res | Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms. | 2008 | Details |
| A27558 | 18073067 | Zhonghua Gan Zang Bing Za Zhi | [The relationship between the opening of mitochondrial permeability transition pores of cultured hepatocytes with their apoptoses in a non-alcoholic fatty liver disease model]. | 2007 | Details |
| A27618 | 24573937 | Front Med China | Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system. | 2007 | Details |
| A27660 | 17567476 | J Gastroenterol Hepatol | Role of adipocytokines in hepatic fibrogenesis. | 2007 | Details |
| A27668 | 17708600 | World J Gastroenterol | Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection. | 2007 | Details |
| A27670 | 17706260 | Toxicol Appl Pharmacol | Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. | 2007 | Details |
| A27681 | 17683488 | J Gastroenterol Hepatol | Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver disease. | 2007 | Details |
| A27683 | 17675901 | J Cardiometab Syndr | Nonalcoholic steatohepatitis and the cardiometabolic syndrome. | 2006 | Details |
| A27688 | 17661414 | Hepatology | Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. | 2007 | Details |
| A27857 | 17236122 | Z Gastroenterol | Cellular and cytokine-mediated mechanisms of inflammation and its modulation in immune-mediated liver injury. | 2007 | Details |
| A27871 | 17198477 | Rev Esp Enferm Dig | Non-alcoholic fatty liver disease. From insulin resistance to mitochondrial dysfunction. | 2006 | Details |
| A27872 | 17188672 | Chem Biol Interact | A human hepatocellular in vitro model to investigate steatosis. | 2006 | Details |
| A27874 | 17181567 | Eur J Clin Invest | Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis. | 2007 | Details |
| A27910 | 17036395 | World J Gastroenterol | Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease. | 2006 | Details |
| A27933 | 16958667 | J Gastroenterol Hepatol | Mitochondrial glutathione: hepatocellular survival-death switch. | 2006 | Details |
| A27937 | 16949573 | Exp Mol Pathol | Transcriptional networks in a rat model for nonalcoholic fatty liver disease: a microarray analysis. | 2006 | Details |
| A27982 | 16799979 | Hepatology | In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. | 2006 | Details |
| A28055 | 16557185 | Minerva Gastroenterol Dietol | Non-alcoholic fatty liver disease and hepatitis C infection. | 2006 | Details |
| A28075 | 16505490 | J Biol Chem | Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. | 2006 | Details |
| A28082 | 16496325 | Hepatology | Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression. | 2006 | Details |
| A28121 | 16374858 | Hepatology | JNK1 but not JNK2 promotes the development of steatohepatitis in mice. | 2006 | Details |
| A28155 | 16252180 | Turk J Gastroenterol | Apoptosis and fibrosis in non-alcoholic fatty liver disease. | 2005 | Details |
| A28190 | 16198624 | Hepatol Res | Lessons from animal models of NASH. | 2005 | Details |
| A28221 | 16092984 | Zhonghua Gan Zang Bing Za Zhi | [A study of the changes of hepatic gene expression in the process of nonalcoholic fatty liver disease development using U230A oligonucleotide microarray]. | 2005 | Details |
| A28236 | 15998427 | Liver Int | Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. | 2005 | Details |
| A28245 | 15970563 | Front Biosci | Apoptosis in alcoholic and nonalcoholic steatohepatitis. | 2005 | Details |
| A28247 | 15970480 | Front Biosci | Uncoupling protein-2 and non-alcoholic fatty liver disease. | 2005 | Details |
| A28318 | 15700216 | Z Gastroenterol | The relationship between apoptosis and non-alcoholic fatty liver disease: an evolutionary cornerstone turned pathogenic. | 2005 | Details |
| A28338 | 15603755 | Mutat Res | Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. | 2005 | Details |
| A28539 | 11838612 | Dig Liver Dis | Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in non-alcoholic steatohepatitis. | 2001 | Details |
| A28558 | 11431335 | Cancer Res | Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? | 2001 | Details |
| A28833 | 34924279 | Drug Resist Updat | Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma? | 2021 | Details |