Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A27774 | 17476695 | Hepatology | Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. | 2007 | Details |
| A27859 | 17230603 | World J Gastroenterol | Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats. | 2007 | Details |
| A27889 | 17105592 | Liver Int | Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease. | 2006 | Details |
| A27936 | 16950832 | Gut | The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis. | 2006 | Details |
| A27945 | 16935387 | J Hepatol | Hepatic gene expression profile associated with non-alcoholic steatohepatitis protection by S-nitroso-N-acetylcysteine in ob/ob mice. | 2006 | Details |
| A27960 | 16895997 | Proc Natl Acad Sci U S A | Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. | 2006 | Details |
| A27964 | 16865780 | World J Gastroenterol | Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. | 2006 | Details |
| A28045 | 16609997 | World J Gastroenterol | Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats. | 2006 | Details |
| A28068 | 16531961 | Ann Hepatol | Pentoxifylline does not prevent neither liver damage nor early profibrogenic events in a rat model of non-alcoholic steatohepatitis. | 2006 | Details |
| A28082 | 16496325 | Hepatology | Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression. | 2006 | Details |
| A28097 | 16436109 | Int J Exp Pathol | Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. | 2006 | Details |
| A28115 | 16385233 | Alcohol Clin Exp Res | Difference and similarity between non-alcoholic steatohepatitis and alcoholic liver disease. | 2005 | Details |
| A28121 | 16374858 | Hepatology | JNK1 but not JNK2 promotes the development of steatohepatitis in mice. | 2006 | Details |
| A28225 | 16051693 | FASEB J | Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). | 2005 | Details |
| A28348 | 15554233 | Drug Metab Rev | The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. | 2004 | Details |
| A28365 | 15464239 | J Hepatol | Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. | 2004 | Details |
| A28430 | 15013444 | Biochem Biophys Res Commun | Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. | 2004 | Details |
| A28448 | 14672613 | J Hepatol | The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. | 2004 | Details |
| A28453 | 14613504 | Nutr J | Vitamin C and vitamin E in prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in choline deficient diet fed rats. | 2003 | Details |
| A28465 | 14535984 | J Gastroenterol Hepatol | Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. | 2003 | Details |
| A28470 | 12971963 | J Hepatol | Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. | 2003 | Details |
| A28472 | 12908728 | Eur Rev Med Pharmacol Sci | Experimental observations and clinical implications of fasting and diet supplementation in fatty livers. | 2003 | Details |
| A28508 | 12406445 | Best Pract Res Clin Gastroenterol | Other disease associations with non-alcoholic fatty liver disease (NAFLD). | 2002 | Details |
| A28514 | 12406439 | Best Pract Res Clin Gastroenterol | Animal models of steatohepatitis. | 2002 | Details |
| A28574 | 10029293 | J Gastroenterol Hepatol | Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats. | 1999 | Details |
| A28578 | 9407327 | J Gastroenterol Hepatol | Abnormality in fatty acid composition of gastric mucosal phospholipids in patients with liver cirrhosis and its correction with a polyunsaturated fatty acid-enriched soft oil capsule. | 1997 | Details |
| A28626 | 35217199 | Biochim Biophys Acta Mol Cell Biol Lipids | Identification cholesterol metabolites altered before the onset of nonalcoholic steatohepatitis by targeted metabolomics. | 2022 | Details |
| A28638 | 35211093 | Front Endocrinol (Lausanne) | The Role of the Intestinal Microbiota in Nonalcoholic Steatohepatitis. | 2022 | Details |
| A28647 | 35189618 | Pharmacology | Docosahexaenoic Acid Attenuates the Progression of Nonalcoholic Steatohepatitis by Suppressing the Adipocyte Inflammation via the G Protein-Coupled Receptor 120/Free Fatty Acid Receptor 4 Pathway. | 2022 | Details |
| A28661 | 35171063 | Pharm Biol | Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. | 2022 | Details |
| A28665 | 35167910 | J Hepatol | Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis. | 2022 | Details |
| A28682 | 35137921 | Int J Mol Med | Resveratrol ameliorates nutritional steatohepatitis through the mmu‑miR‑599/PXR pathway. | 2022 | Details |
| A28690 | 35126150 | Front Pharmacol | Deciphering the Effective Constituents and Mechanisms of Portulaca oleracea L. for Treating NASH via Integrating Bioinformatics Analysis and Experimental Pharmacology. | 2022 | Details |
| A28725 | 35092323 | J Magn Reson Imaging | Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis. | 2022 | Details |
| A28759 | 35052810 | Biomedicines | Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis. | 2022 | Details |
| A28783 | 35006626 | Hepatology | Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase. | 2022 | Details |
| A28972 | 34760013 | Res Pharm Sci | Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis: role of SIRT1/Nrf2 pathway. | 2021 | Details |
| A29002 | 34716927 | Hepatology | Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies. | 2021 | Details |
| A29007 | 34712137 | Front Pharmacol | Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy. | 2021 | Details |
| A29027 | 34679736 | Antioxidants (Basel) | Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney. | 2021 | Details |
| A29029 | 34676758 | J Proteome Res | Nontargeted Serum Lipid Profiling of Nonalcoholic Steatohepatitis by Multisegment Injection-Nonaqueous Capillary Electrophoresis-Mass Spectrometry: A Multiplexed Separation Platform for Resolving Ionic Lipids. | 2021 | Details |
| A29069 | 34624527 | Cell Mol Gastroenterol Hepatol | Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. | 2021 | Details |
| A29148 | 34506952 | Cell Mol Gastroenterol Hepatol | Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway. | 2021 | Details |
| A29185 | 34439245 | Cancers (Basel) | Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC. | 2021 | Details |
| A29211 | 34411785 | Cell Mol Gastroenterol Hepatol | SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis. | 2021 | Details |
| A29226 | 34390210 | FEBS Open Bio | Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways. | 2021 | Details |
| A29264 | 34341511 | Acta Pharmacol Sin | Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis. | 2021 | Details |
| A29303 | 34278710 | Aging Cell | Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. | 2021 | Details |
| A29316 | 34262459 | Front Pharmacol | Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway. | 2021 | Details |
| A29423 | 34093242 | Front Physiol | Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization. | 2021 | Details |
| A29494 | 33987382 | Ann Transl Med | The effects of S-nitrosylation-induced PPARγ/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis. | 2021 | Details |
| A29623 | 33787460 | J Recept Signal Transduct Res | SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH). | 2021 | Details |
| A29742 | 33590776 | Gut Microbes | The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases. | 2022 | Details |
| A29750 | 33574830 | Front Genet | Downregulated microRNA-129-5p by Long Non-coding RNA NEAT1 Upregulates PEG3 Expression to Aggravate Non-alcoholic Steatohepatitis. | 2021 | Details |
| A29876 | 33354276 | Oxid Med Cell Longev | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | 2020 | Details |
| A29905 | 33293985 | Evid Based Complement Alternat Med | Effects of Qutan Huoxue Formula on the SOCS1/TLR4 Signaling Pathway in NASH Model Mice. | 2020 | Details |
| A29919 | 33277568 | Sci Rep | Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. | 2020 | Details |
| A29936 | 33247991 | Hepatol Res | Angiopoietin-like protein 4 deficiency augments liver fibrosis in liver diseases such as nonalcoholic steatohepatitis in mice through enhanced free cholesterol accumulation in hepatic stellate cells. | 2021 | Details |
| A30098 | 32990984 | J Bone Miner Res | A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. | 2020 | Details |
| A30146 | 32903542 | Front Cell Dev Biol | Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. | 2020 | Details |
| A30168 | 32875214 | ACS Omega | Epigallocatechin Gallate Protects Mice against Methionine-Choline-Deficient-Diet-Induced Nonalcoholic Steatohepatitis by Improving Gut Microbiota To Attenuate Hepatic Injury and Regulate Metabolism. | 2020 | Details |
| A30275 | 32713066 | J Food Biochem | β-Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline-deficient diet in mice. | 2020 | Details |
| A30360 | 32575352 | Microorganisms | Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30436 | 32448510 | Biochem Biophys Res Commun | Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. | 2020 | Details |
| A30453 | 32425782 | Front Pharmacol | Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats. | 2020 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A30570 | 32195263 | Front Med (Lausanne) | Myricetin Modulates Macrophage Polarization and Mitigates Liver Inflammation and Fibrosis in a Murine Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30666 | 32025163 | J Clin Exp Hepatol | Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort. | 2019 | Details |
| A31130 | 31193082 | Heliyon | Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism. | 2019 | Details |
| A31144 | 31177586 | Hepatol Res | Combined effect of a farnesoid X receptor agonist and dipeptidyl peptidase-4 inhibitor on hepatic fibrosis. | 2019 | Details |
| A31161 | 31120771 | FASEB J | Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine-choline-deficient rats. | 2019 | Details |
| A31179 | 31097447 | Biol Open | Dietary iron restriction leads to a reduction in hepatic fibrosis in a rat model of non-alcoholic steatohepatitis. | 2019 | Details |
| A31189 | 31068812 | Front Pharmacol | Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin. | 2019 | Details |
| A31337 | 30766962 | Hepatol Commun | An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A31375 | 30705600 | Diabetes Metab Syndr Obes | Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats. | 2019 | Details |
| A31417 | 30615497 | FASEB J | A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. | 2019 | Details |
| A31425 | 30595544 | Nucl Med Biol | Validation of hepatobiliary transport PET imaging in liver function assessment: Evaluation of 3β-[18F]FCA in mouse models of liver disease. | 2018 | Details |
| A31531 | 30367397 | J Gastrointest Surg | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. | 2018 | Details |
| A31619 | 30186272 | Front Microbiol | Butyrate Protects Mice Against Methionine-Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels. | 2018 | Details |
| A31682 | 30048033 | Hepatol Res | Homocysteine supplementation ameliorates steatohepatitis induced by a choline-deficient diet in mice. | 2018 | Details |
| A31722 | 29983886 | Oncotarget | Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model. | 2018 | Details |
| A31819 | 29761169 | Hepatol Commun | Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis. | 2018 | Details |
| A31978 | 29404501 | Hepatol Commun | Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis. | 2017 | Details |
| A31981 | 29404476 | Hepatol Commun | The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | 2017 | Details |
| A31996 | 29369831 | Curr Opin Lipidol | Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice. | 2018 | Details |
| A32019 | 30906835 | Genes Dis | Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood. | 2018 | Details |
| A32060 | 29278707 | Biochem Biophys Res Commun | Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition. | 2017 | Details |
| A32096 | 29197066 | Br J Pharmacol | Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. | 2018 | Details |
| A32130 | 29143759 | Antioxidants (Basel) | The Role of Food Antioxidants, Benefits of Functional Foods, and Influence of Feeding Habits on the Health of the Older Person: An Overview. | 2017 | Details |
| A32152 | 29097836 | J Toxicol Pathol | The effect of β-caryophyllene on nonalcoholic steatohepatitis. | 2017 | Details |
| A32226 | 28933629 | Autophagy | Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. | 2017 | Details |
| A32276 | 28808187 | J Biomed Res | G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A32305 | 31966664 | Int J Clin Exp Pathol | Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation. | 2017 | Details |
| A32319 | 28725667 | Data Brief | Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis. | 2017 | Details |
| A32418 | 28495138 | J Neuroimmunol | Effect of ethnic origin and gender on the clinical manifestations of myasthenia gravis among the Jewish population in Israel. | 2017 | Details |
| A32463 | 28385694 | Am J Physiol Gastrointest Liver Physiol | Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis. | 2017 | Details |
| A32468 | 28365916 | Dig Dis Sci | Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. | 2017 | Details |
| A32548 | 28133511 | Toxicol Res | Evaluating the Influence of Side Stream Cigarette Smoke at an Early Stage of Non-Alcoholic Steatohepatitis Progression in Mice. | 2017 | Details |
| A32582 | 28066964 | Hepatol Res | Mechanisms of the prevention and inhibition of the progression and development of non-alcoholic steatohepatitis by genetic and pharmacological decoy receptor 3 supplementation. | 2017 | Details |
| A32601 | 28029729 | Hepatol Res | Combined treatment with dipeptidyl peptidase-4 inhibitor (sitagliptin) and angiotensin-II type 1 receptor blocker (losartan) suppresses progression in a non-diabetic rat model of steatohepatitis. | 2017 | Details |