Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A09610 | 31676768 | Exp Mol Med | Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. | 2019 | Details |
| A09613 | 31674780 | J Agric Food Chem | γ-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells. | 2019 | Details |
| A09614 | 31673703 | Endocrinology | Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression. | 2020 | Details |
| A09619 | 31672578 | Life Sci | Amlexanox reversed non-alcoholic fatty liver disease through IKKε inhibition of hepatic stellate cell. | 2019 | Details |
| A09623 | 31671697 | Cells | Why Bile Acids Are So Important in Non-Alcoholic Fatty Liver Disease (NAFLD) Progression. | 2019 | Details |
| A09629 | 31668954 | Environ Pollut | Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. | 2019 | Details |
| A09632 | 31668396 | Mol Metab | PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease. | 2019 | Details |
| A09635 | 31668088 | Int J Environ Health Res | Evaluation of sucrose-enriched diet consumption in the development of risk factors associated to type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease in a murine model. | 2019 | Details |
| A09648 | 31659239 | Acta Pharmacol Sin | Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway. | 2019 | Details |
| A09666 | 31653116 | Int J Mol Sci | The Positive Effects of Grifola frondosa Heteropolysaccharide on NAFLD and Regulation of the Gut Microbiota. | 2019 | Details |
| A09681 | 31650383 | Mol Biol Rep | High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes. | 2019 | Details |
| A09683 | 31650134 | Food Funct | Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats. | 2019 | Details |
| A09701 | 31640183 | Nutrients | Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09702 | 31639005 | Lipids Health Dis | Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis. | 2019 | Details |
| A09703 | 31638854 | Am J Physiol Endocrinol Metab | Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis. | 2019 | Details |
| A09706 | 31638173 | Int J Mol Med | Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease. | 2019 | Details |
| A09712 | 31636851 | Toxicol Res | Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice. | 2019 | Details |
| A09732 | 31632452 | Nutr Metab (Lond) | Hepatic PKA inhibition accelerates the lipid accumulation in liver. | 2019 | Details |
| A09736 | 31631098 | Endocr J | Regulation of angiopoietin-like protein 8 expression under different nutritional and metabolic status. | 2019 | Details |
| A09739 | 31630534 | Am J Physiol Gastrointest Liver Physiol | Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer. | 2019 | Details |
| A09742 | 31629472 | Biochem Biophys Res Commun | MC4R deficiency in pigs results in hyperphagia and ultimately hepatic steatosis without high-fat diet. | 2019 | Details |
| A09766 | 31618976 | Int J Mol Sci | The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD. | 2019 | Details |
| A09775 | 31614673 | Cells | Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells. | 2019 | Details |
| A09776 | 31614650 | J Clin Med | Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. | 2019 | Details |
| A09778 | 31614590 | Int J Mol Sci | Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells. | 2019 | Details |
| A09805 | 31604029 | Am J Physiol Gastrointest Liver Physiol | Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A09814 | 31600750 | Digestion | Rodent Models of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09825 | 31597607 | Trends Endocrinol Metab | Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09842 | 31593687 | Eur J Pharmacol | Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy. | 2019 | Details |
| A09850 | 31592021 | Hepatol Commun | Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA. | 2019 | Details |
| A09855 | 31590127 | Biomed Pharmacother | Nr2e1 ablation impairs liver glucolipid metabolism and induces inflammation, high-fat diets amplify the damage. | 2019 | Details |
| A09859 | 31589122 | Curr Drug Targets | Natural Aldose Reductase Inhibitor: A Potential Therapeutic Agent for Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A09872 | 31581241 | PLoS Comput Biol | A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data. | 2019 | Details |
| A09873 | 31581129 | Endocr Connect | Hyperinsulinaemia: does it tip the balance toward intrahepatic fat accumulation? | 2019 | Details |
| A09875 | 31579588 | PeerJ | FoxO1 is a critical regulator of hepatocyte lipid deposition in chronic stress mice. | 2019 | Details |
| A09876 | 31578240 | Sci Transl Med | Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. | 2019 | Details |
| A09881 | 31576092 | World J Gastroenterol | Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. | 2019 | Details |
| A09891 | 31573042 | Int J Mol Med | Fatty liver and alteration of the gut microbiome induced by diallyl disulfide. | 2019 | Details |
| A09895 | 31570772 | Lab Invest | Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2. | 2019 | Details |
| A09923 | 31558861 | World J Gastroenterol | Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways. | 2019 | Details |
| A09924 | 31558860 | World J Gastroenterol | Regulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease. | 2019 | Details |
| A09925 | 31558417 | Ann Hepatol | Characteristics of intestinal bacteria with fatty liver diseases and cirrhosis. | 2019 | Details |
| A09933 | 31554932 | Nat Rev Endocrinol | The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state. | 2019 | Details |
| A09941 | 31551937 | Front Endocrinol (Lausanne) | Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats. | 2019 | Details |
| A09946 | 31548878 | Cell Biosci | BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling. | 2019 | Details |
| A09952 | 31545283 | Biomed Pharmacother | Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression. | 2019 | Details |
| A09968 | 31541078 | Exp Mol Med | Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis. | 2019 | Details |
| A09972 | 31539884 | J Physiol Pharmacol | Diverse inhibition of forkhead box O1 activity by linoleic acid isomers - potential role in lipid metabolism in HepG2 cells and livers of C57BL/6J mice. | 2019 | Details |
| A09986 | 31535735 | Nutr Clin Pract | Nonalcoholic Fatty Pancreas Disease. | 2019 | Details |
| A09989 | 31534518 | Theranostics | Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System. | 2019 | Details |
| A10002 | 31529722 | Hepatology | Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. | 2020 | Details |
| A10024 | 31520816 | J Nutr Biochem | Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy. | 2019 | Details |
| A10030 | 31519174 | BMC Complement Altern Med | Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells. | 2019 | Details |
| A10049 | 31514051 | Redox Biol | Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function. | 2019 | Details |
| A10050 | 31514003 | Chemosphere | Transcriptome analysis in normal human liver cells exposed to 2, 3, 3', 4, 4', 5 - Hexachlorobiphenyl (PCB 156). | 2019 | Details |
| A10063 | 31505325 | Redox Biol | Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling. | 2019 | Details |
| A10064 | 31505261 | Biochim Biophys Acta Mol Cell Biol Lipids | Lipid accumulation impairs lysosomal acid lipase activity in hepatocytes: Evidence in NAFLD patients and cell cultures. | 2019 | Details |
| A10068 | 31503515 | Am J Physiol Endocrinol Metab | HDL flux is higher in patients with nonalcoholic fatty liver disease. | 2019 | Details |
| A10085 | 31493478 | Life Sci | Strength training reduces lipid accumulation in liver of obese Wistar rats. | 2019 | Details |
| A10088 | 31492960 | Sci Rep | Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. | 2019 | Details |
| A10090 | 31491949 | Int J Mol Sci | Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis. | 2019 | Details |
| A10091 | 31491605 | Ecotoxicol Environ Saf | Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. | 2019 | Details |
| A10092 | 31491513 | Int J Biol Macromol | MDG-1, an Ophiopogon polysaccharide, restrains process of non-alcoholic fatty liver disease via modulating the gut-liver axis. | 2019 | Details |
| A10098 | 31485221 | Int J Endocrinol | Compound C Protects Mice from HFD-Induced Obesity and Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | 2019 | Details |
| A10102 | 31484042 | Life Sci | LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p/ROCK1 in nonalcoholic fatty liver disease. | 2019 | Details |
| A10122 | 31474685 | J Nutr Sci Vitaminol (Tokyo) | Age-Related Alterations of Nonalcoholic Steatohepatitis in Sprague-Dawley Rats Fed a High-Fat and High-Cholesterol Diet. | 2019 | Details |
| A10125 | 31474632 | Yakugaku Zasshi | [Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology]. | 2019 | Details |
| A10131 | 31473346 | Biochim Biophys Acta Mol Cell Biol Lipids | Exercise regulates lipid droplet dynamics in normal and fatty liver. | 2019 | Details |
| A10144 | 31470288 | Nutr Res | Gnotobiotic mice inoculated with Firmicutes, but not Bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism. | 2019 | Details |
| A10155 | 31465774 | Biochem Pharmacol | Functions of aryl hydrocarbon receptor (AHR) and CD38 in NAD metabolism and nonalcoholic steatohepatitis (NASH). | 2019 | Details |
| A10167 | 31460789 | Am J Physiol Gastrointest Liver Physiol | Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis. | 2019 | Details |
| A10174 | 31454158 | Mol Nutr Food Res | Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. | 2019 | Details |
| A10175 | 31452288 | Phytother Res | Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice. | 2019 | Details |
| A10185 | 31445019 | Biochem Pharmacol | M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway. | 2019 | Details |
| A10198 | 31437454 | Gastrointest Endosc | EUS-guided core liver biopsy sampling using a 22-gauge fork-tip needle: a prospective blinded trial for histologic and lipidomic evaluation in nonalcoholic fatty liver disease. | 2019 | Details |
| A10203 | 31435171 | World J Gastroenterol | Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease? | 2019 | Details |
| A10210 | 31430977 | Int J Mol Sci | Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders. | 2019 | Details |
| A10214 | 31430204 | Am J Physiol Endocrinol Metab | Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway. | 2019 | Details |
| A10218 | 31426291 | Int J Mol Sci | Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease. | 2019 | Details |
| A10223 | 31422074 | Arch Biochem Biophys | CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation. | 2019 | Details |
| A10232 | 31419516 | Pharmacol Ther | The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease. | 2019 | Details |
| A10235 | 31419414 | Clin Chim Acta | Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. | 2019 | Details |
| A10237 | 31418509 | Phytother Res | Fiber and phenolic compounds contribution to the hepatoprotective effects of mango diets in rats fed high cholesterol/sodium cholate. | 2019 | Details |
| A10239 | 31417486 | Front Neurol | Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. | 2019 | Details |
| A10247 | 31413241 | J Oleo Sci | Elaeagnus mollis Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolismrelated Genes. | 2019 | Details |
| A10254 | 31409773 | Cell Death Dis | mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma. | 2019 | Details |
| A10255 | 31409765 | Exp Mol Med | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption. | 2019 | Details |
| A10260 | 31408437 | J Clin Invest | Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis. | 2019 | Details |
| A10262 | 31408176 | J Clin Endocrinol Metab | Hepatic Fatty Acid Balance and Hepatic Fat Content in Humans With Severe Obesity. | 2019 | Details |
| A10270 | 31405127 | Nutrients | Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice. | 2019 | Details |
| A10275 | 31402618 | Ann Clin Transl Neurol | Abnormal fatty acid metabolism is a core component of spinal muscular atrophy. | 2019 | Details |
| A10279 | 31401392 | Biomed Pharmacother | Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. | 2019 | Details |
| A10280 | 31401389 | Cell Calcium | Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. | 2019 | Details |
| A10288 | 31398468 | Biochim Biophys Acta Mol Basis Dis | Vibrational spectroscopy-based quantification of liver steatosis. | 2019 | Details |
| A10304 | 31392349 | Cell Mol Life Sci | Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARγ pathways. | 2019 | Details |
| A10314 | 31389309 | Thyroid | Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists. | 2019 | Details |
| A10325 | 31387306 | Int J Mol Sci | High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD. | 2019 | Details |
| A10326 | 31387260 | Antioxidants (Basel) | Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis In Vitro. | 2019 | Details |