Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Tumor necrosis factor1477 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A47215 | 22538404 | Am J Physiol Gastrointest Liver Physiol | Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. | 2012 | Details |
| A47222 | 22413959 | Alcohol Clin Exp Res | Carvedilol attenuates the progression of alcohol fatty liver disease in rats. | 2012 | Details |
| A47230 | 22169690 | Zhonghua Yu Fang Yi Xue Za Zhi | [The effects of NF-E2-related factor-2 prompter polymorphism on alcoholic liver disease with Vibrio vulnificus sepsis]. | 2011 | Details |
| A47237 | 21826088 | Nat Rev Gastroenterol Hepatol | Alcoholic liver disease: pathogenesis and new targets for therapy. | 2011 | Details |
| A47242 | 21673994 | PLoS One | Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. | 2011 | Details |
| A47249 | 21423135 | Lab Invest | Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. | 2011 | Details |
| A47258 | 20955970 | Best Pract Res Clin Gastroenterol | Alcoholic steatohepatitis. | 2010 | Details |
| A47261 | 20399524 | J Hepatol | Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. | 2010 | Details |
| A47266 | 20041784 | J Med Food | Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. | 2009 | Details |
| A47275 | 19608736 | Am J Physiol Gastrointest Liver Physiol | Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver. | 2009 | Details |
| A47277 | 19588123 | Arch Toxicol | Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | 2009 | Details |
| A47278 | 19372631 | J Pharmacol Sci | Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c. | 2009 | Details |
| A47279 | 19371623 | Toxicol Appl Pharmacol | Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. | 2009 | Details |
| A47281 | 19239162 | Adv Exp Med Biol | Effect of taurine on alcoholic liver disease in rats. | 2009 | Details |
| A47290 | 19003881 | Hepatology | Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. | 2008 | Details |
| A47292 | 18722787 | Cytokine | Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. | 2008 | Details |
| A47294 | 18599584 | Am J Physiol Gastrointest Liver Physiol | Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. | 2008 | Details |
| A47297 | 18534708 | Diabetes Res Clin Pract | Fatty liver and chronic inflammation in Chinese adults. | 2008 | Details |
| A47298 | 18509591 | Amino Acids | Effect of taurine on alcoholic liver disease in rats. | 2008 | Details |
| A47301 | 18336673 | J Gastroenterol Hepatol | Cholesterol and sphingolipids in alcohol-induced liver injury. | 2008 | Details |
| A47302 | 18395093 | Gastroenterology | Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. | 2008 | Details |
| A47304 | 18341647 | Alcohol Clin Exp Res | A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. | 2008 | Details |
| A47305 | 18339590 | Dig Liver Dis | Inhibitory effect of osthole on alcohol-induced fatty liver in mice. | 2008 | Details |
| A47309 | 17850215 | Alcohol Clin Exp Res | Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. | 2007 | Details |
| A47312 | 17616758 | Am J Clin Nutr | Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. | 2007 | Details |
| A47316 | 17328242 | Arch Pharm Res | Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion. | 2007 | Details |
| A47319 | 17203086 | Nat Clin Pract Gastroenterol Hepatol | Management strategies in alcoholic liver disease. | 2007 | Details |
| A47323 | 17058832 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Relationship between alcoholic liver injury and endotoxin leakage from gut and intervention effect of jianpi liqi huoxue decoction]. | 2006 | Details |
| A47326 | 16958678 | J Gastroenterol Hepatol | Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. | 2006 | Details |
| A47327 | 16958658 | J Gastroenterol Hepatol | Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. | 2006 | Details |
| A47335 | 16227360 | Gut | Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. | 2005 | Details |
| A47336 | 16170395 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy. | 2005 | Details |
| A47345 | 15368449 | Hepatology | Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. | 2004 | Details |
| A47352 | 14647036 | J Lab Clin Med | Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. | 2003 | Details |
| A47362 | 12512042 | Gastroenterology | Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. | 2003 | Details |
| A47383 | 10235499 | Arch Pathol Lab Med | The antigenic heterogeneity of the bile duct epithelium in alcoholic liver disease. VA Cooperative Study Group 275. | 1999 | Details |
| A47388 | 9622456 | Alcohol Clin Exp Res | Altered T-lymphocyte responsiveness to polyclonal cell activators is responsible for liver cell necrosis in alcohol-fed rats. | 1998 | Details |
| A47397 | 9397995 | Hepatology | Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. | 1997 | Details |
| A47398 | 9309314 | Alcohol Clin Exp Res | Choline deficiency augments and antibody to tumor necrosis factor-alpha attenuates endotoxin-induced hepatic injury. | 1997 | Details |
| A47404 | 9195371 | J Gastroenterol Hepatol | Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. | 1997 | Details |
| A47407 | 8978360 | Gastroenterology | Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat. | 1997 | Details |
| A47421 | 8525652 | Z Gastroenterol | Tumor-necrosis-factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease. | 1995 | Details |
| A47777 | 32108953 | Hepatology | Decreased Hepatocyte Autophagy Leads to Synergistic IL-1β and TNF Mouse Liver Injury and Inflammation. | 2020 | Details |
| A47903 | 29619419 | Hepatol Commun | Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice. | 2018 | Details |
| A47923 | 29191940 | Am J Physiol Gastrointest Liver Physiol | Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation. | 2017 | Details |
| A47957 | 28236037 | Inflammopharmacology | PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. | 2017 | Details |
| A47974 | 27659424 | Am J Physiol Gastrointest Liver Physiol | Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity. | 2016 | Details |
| A47980 | 27443844 | Mol Cell Biochem | A20 reduces lipid storage and inflammation in hypertrophic adipocytes via p38 and Akt signaling. | 2016 | Details |
| A47999 | 26872435 | J Microbiol Immunol Infect | Serum pentraxin-3 and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) predict severity of infections in acute decompensated cirrhotic patients. | 2016 | Details |
| A48009 | 26686910 | Reprod Toxicol | Anti-inflammatory potential of β-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells. | 2015 | Details |
| A48010 | 26634212 | Biomed Res Int | The Influence of α-Lipoic Acid and Garlic Administration on Biomarkers of Oxidative Stress and Inflammation in Rabbits Exposed to Oxidized Nutrition Oils. | 2015 | Details |
| A48079 | 24726754 | Gastroenterology | Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis. | 2014 | Details |
| A48109 | 23226929 | Mediators Inflamm | Simulating sleep apnea by exposure to intermittent hypoxia induces inflammation in the lung and liver. | 2012 | Details |
| A48136 | 21941003 | J Biol Chem | Death receptor 5 signaling promotes hepatocyte lipoapoptosis. | 2011 | Details |
| A48161 | 20953409 | Vet Med Int | Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. | 2010 | Details |
| A48267 | 18032466 | Am J Physiol Regul Integr Comp Physiol | Attenuation of acute and chronic liver injury in rats by iron-deficient diet. | 2007 | Details |
| A48272 | 17916356 | Gastroenterology | Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. | 2007 | Details |
| A48302 | 17023554 | Am J Physiol Gastrointest Liver Physiol | Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. | 2006 | Details |
| A48326 | 16494792 | Zhonghua Gan Zang Bing Za Zhi | [Role of peroxisome proliferator activated receptor alpha in the pathogenesis of nonalcoholic steatohepatitis]. | 2006 | Details |
| A48331 | 16344599 | Alcohol Clin Exp Res | Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. | 2005 | Details |
| A48357 | 15368448 | Hepatology | Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. | 2004 | Details |
| A48359 | 15329221 | Zhonghua Gan Zang Bing Za Zhi | [Expression of CD35 on erythrocyte and the changes of serum inflammatory cytokines in patients with nonalcoholic steatohepatitis and its immune regulation]. | 2004 | Details |
| A48383 | 12866461 | Nihon Naika Gakkai Zasshi | [Recent topics on nonalcoholic steatohepatitis]. | 2003 | Details |
| A48420 | 11804839 | Am J Physiol Gastrointest Liver Physiol | Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis. | 2002 | Details |
| A48527 | 34727968 | BMC Res Notes | Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial-mesenchymal transition in ARPE-19 cells. | 2021 | Details |
| A48632 | 32649971 | J Hepatol | Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis. | 2020 | Details |
| A48798 | 28392436 | J Immunol Methods | An oral administration of a recombinant anti-TNF fusion protein is biologically active in the gut promoting regulatory T cells: Results of a phase I clinical trial using a novel oral anti-TNF alpha-based therapy. | 2017 | Details |
| A48824 | 27498701 | Sci Rep | Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. | 2016 | Details |
| A48847 | 26738395 | Br J Biomed Sci | Pentraxin-3 and nitric oxide as indicators of disease severity in alcoholic cirrhosis. | 2015 | Details |
| A48857 | 26448681 | Mediators Inflamm | C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. | 2015 | Details |
| A48898 | 25251280 | Hepatology | Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. | 2015 | Details |
| A48908 | 24814604 | Am J Pathol | Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. | 2014 | Details |
| A48911 | 24796378 | Hepatol Res | Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice. | 2014 | Details |
| A48916 | 24592262 | Front Immunol | TWEAK and LTβ Signaling during Chronic Liver Disease. | 2014 | Details |
| A48921 | 24400890 | J Cell Mol Med | The functional role of microRNAs in alcoholic liver injury. | 2014 | Details |
| A48951 | 23388073 | Lipids Health Dis | Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. | 2013 | Details |
| A48963 | 23057725 | Hepatol Res | Fatty liver Shionogi-ob/ob mouse: A new candidate for a non-alcoholic steatohepatitis model. | 2012 | Details |
| A48964 | 23027617 | Carcinogenesis | Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | 2012 | Details |
| A48974 | 22637703 | Gut | Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. | 2012 | Details |
| A48999 | 21951423 | Hepatol Res | Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice. | 2011 | Details |
| A49009 | 21466434 | Curr Pharm Biotechnol | Silymarin in the prevention and treatment of liver diseases and primary liver cancer. | 2012 | Details |
| A49027 | 20969493 | Scand J Gastroenterol | Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. | 2010 | Details |
| A49083 | 18537187 | Hepatology | Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial. | 2008 | Details |
| A49091 | 18336675 | J Gastroenterol Hepatol | Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. | 2008 | Details |
| A49106 | 17435339 | Nihon Yakurigaku Zasshi | [Candidate drugs for non-alcoholic steatohepatitis (NASH)]. | 2007 | Details |
| A49141 | 16448457 | Liver Int | The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases. | 2006 | Details |
| A49143 | 16340448 | Alcohol Clin Exp Res | -238 G>A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men. | 2005 | Details |
| A49154 | 16137475 | Gastroenterol Hepatol | [Etiopathogenesis of non-alcoholic steatohepatitis]. | 2005 | Details |
| A49174 | 15504303 | Zhonghua Gan Zang Bing Za Zhi | [The role of enterogenous endotoxemia in the pathogenesis of non-alcoholic steatohepatitis]. | 2004 | Details |
| A49176 | 15475485 | Am J Physiol Gastrointest Liver Physiol | Leptin deficiency enhances sensitivity of rats to alcoholic steatohepatitis through suppression of metallothionein. | 2004 | Details |
| A49233 | 35814507 | J Clin Exp Hepatol | Demonstration of Gut-Barrier Dysfunction in Early Stages of Non-alcoholic Fatty Liver Disease: A Proof-Of-Concept Study. | 2022 | Details |
| A49234 | 35813333 | Ann Transl Med | Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice. | 2022 | Details |
| A49245 | 35811658 | Dis Markers | Pharmacological Mechanism of Ganlu Powder in the Treatment of NASH Based on Network Pharmacology and Molecular Docking. | 2022 | Details |
| A49309 | 35792732 | Biomarkers | Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage. | 2022 | Details |
| A49352 | 35780841 | Life Sci | Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q/tumor necrosis factor-related protein-3 and ATP citrate lyase. | 2022 | Details |
| A49396 | 35765026 | J Transl Med | Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. | 2022 | Details |
| A49443 | 35748073 | Yonsei Med J | Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy. | 2022 | Details |
| A49481 | 35740285 | Biomedicines | Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation. | 2022 | Details |
| A49524 | 35726797 | Food Funct | Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. | 2022 | Details |
| A49534 | 35723052 | Food Funct | Coffee peel extracts ameliorate non-alcoholic fatty liver disease via a fibroblast growth factor 21-adiponectin signaling pathway. | 2022 | Details |