Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A04516 | 33590934 | Liver Int | Prevalence of NAFLD, MAFLD and associated advanced fibrosis in the contemporary United States population. | 2021 | Details |
| A04517 | 33590598 | Liver Int | Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: A cost-of-illness analysis. | 2021 | Details |
| A04521 | 33588102 | Mol Metab | Stress kinases in the development of liver steatosis and hepatocellular carcinoma. | 2021 | Details |
| A04528 | 33586354 | ESC Heart Fail | Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT. | 2021 | Details |
| A04530 | 33586120 | Diabetes Ther | Empagliflozin Improves Liver Steatosis and Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. | 2021 | Details |
| A04531 | 33586025 | J Endocrinol Invest | Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model. | 2021 | Details |
| A04538 | 33584545 | Front Endocrinol (Lausanne) | TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism. | 2021 | Details |
| A04539 | 33584535 | Front Endocrinol (Lausanne) | Correlations Between MRI Biomarkers PDFF and cT1 With Histopathological Features of Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A04541 | 33584141 | J Med Biochem | Clinical relevance of lipid panel and aminotransferases in the context of hepatic steatosis and fibrosis as measured by transient elastography (FibroScan®). | 2021 | Details |
| A04543 | 33584072 | World J Gastroenterol | Histopathology and the predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy. | 2021 | Details |
| A04546 | 33583577 | Clin Ther | Therapy for Nonalcoholic Fatty Liver Disease: Current Options and Future Directions. | 2021 | Details |
| A04559 | 33580453 | Hepatol Int | The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040. | 2021 | Details |
| A04562 | 33579423 | Adv Cancer Res | NAFLD-related HCC. | 2021 | Details |
| A04564 | 33578800 | Cancers (Basel) | Inflammatory Mechanisms Underlying Nonalcoholic Steatohepatitis and the Transition to Hepatocellular Carcinoma. | 2021 | Details |
| A04569 | 33577920 | J Hepatol | Diagnosis and management of secondary causes of steatohepatitis. | 2021 | Details |
| A04570 | 33577616 | PLoS One | Hepatorenal index for grading liver steatosis with concomitant fibrosis. | 2021 | Details |
| A04573 | 33576035 | Hepatology | Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway. | 2021 | Details |
| A04577 | 33574818 | Front Immunol | Predicting Non-Alcoholic Fatty Liver Disease Progression and Immune Deregulations by Specific Gene Expression Patterns. | 2021 | Details |
| A04580 | 33573891 | J Diabetes Complications | Importance of non-invasive liver fibrosis scores for mortality and complications development in individuals with type 2 diabetes. | 2021 | Details |
| A04584 | 33572810 | Nutrients | Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity. | 2021 | Details |
| A04585 | 33572797 | Cancers (Basel) | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma. | 2021 | Details |
| A04590 | 33571553 | J Hepatol | Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. | 2021 | Details |
| A04593 | 33570776 | Hepatology | A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH. | 2021 | Details |
| A04595 | 33569851 | J Gastroenterol Hepatol | Simple non-invasive scoring systems and histological scores in predicting mortality in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis. | 2021 | Details |
| A04596 | 33569476 | Ann Transl Med | A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases. | 2021 | Details |
| A04597 | 33568925 | Diabetes Metab Syndr Obes | The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity. | 2021 | Details |
| A04598 | 33568794 | Nat Rev Gastroenterol Hepatol | Therapeutic pipeline in nonalcoholic steatohepatitis. | 2021 | Details |
| A04616 | 33561928 | Ultrasonography | Liver stiffness quantification in biopsy-proven nonalcoholic fatty liver disease patients using shear wave elastography in comparison with transient elastography. | 2020 | Details |
| A04625 | 33559024 | Biol Trace Elem Res | Nonalcoholic Steatohepatitis Modifies Serum Iron-Related Variables in Patients with Morbid Obesity. | 2021 | Details |
| A04631 | 33557304 | Antioxidants (Basel) | Oxidized High-Density Lipoprotein Shows a Stepwise Increase as Fibrosis Progresses in Patients with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04635 | 33556256 | Scand J Gastroenterol | Serum levels of endotrophin are associated with nonalcoholic steatohepatitis. | 2021 | Details |
| A04641 | 33554097 | JHEP Rep | Non-alcoholic fatty liver disease does not increase dementia risk although histology data might improve risk prediction. | 2020 | Details |
| A04644 | 33553966 | Hepatol Commun | Nonalcoholic Fatty Liver Disease Screening in Type 2 Diabetes Mellitus Patients in the Primary Care Setting. | 2020 | Details |
| A04650 | 33551355 | Dig Liver Dis | Liver fibrosis in patients with metabolic associated fatty liver disease is a risk factor for adverse outcomes in COVID-19. | 2021 | Details |
| A04651 | 33551215 | Clin Nutr | Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A04653 | 33550587 | Hepatology | Heterogeneity of HSCs in a Mouse Model of NASH. | 2021 | Details |
| A04657 | 33549735 | Ann Hepatol | Hepatic steatosis and respiratory diseases: a new panorama. | 2021 | Details |
| A04661 | 33548472 | J Nutr Biochem | Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets. | 2021 | Details |
| A04673 | 33545430 | Cell Mol Gastroenterol Hepatol | Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH. | 2021 | Details |
| A04674 | 33545428 | Cell Mol Gastroenterol Hepatol | SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04675 | 33545391 | Mol Metab | Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH. | 2021 | Details |
| A04679 | 33544802 | Rom J Morphol Embryol | The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients. | 2021 | Details |
| A04683 | 33544129 | Clin Infect Dis | Change in Fibrosis 4 Index as Predictor of High Risk of Incident Hepatocellular Carcinoma After Eradication of Hepatitis C Virus. | 2021 | Details |
| A04686 | 33542909 | Can J Gastroenterol Hepatol | Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis. | 2021 | Details |
| A04688 | 33541866 | Gut | Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach? | 2021 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A04696 | 33536590 | Sci Rep | The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs. | 2021 | Details |
| A04697 | 33536476 | Sci Rep | Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. | 2021 | Details |
| A04698 | 33536442 | Sci Rep | Clinical implications of renin-angiotensin system inhibitors for development and progression of non-alcoholic fatty liver disease. | 2021 | Details |
| A04703 | 33535211 | Dig Dis | NASH/Liver Fibrosis Prevalence and Incidence of Nonliver Comorbidities among People with NAFLD and Incidence of NAFLD by Metabolic Comorbidities: Lessons from South Korea. | 2021 | Details |
| A04706 | 33534958 | ESC Heart Fail | Non-alcoholic fatty liver disease and heart failure with preserved ejection fraction: from pathophysiology to practical issues. | 2021 | Details |
| A04720 | 33529485 | HIV Med | Diagnostic value of serological biomarkers for detection of non-alcoholic fatty liver disease (NAFLD) and/or advanced liver fibrosis in people living with HIV. | 2021 | Details |
| A04723 | 33528280 | Scand J Clin Lab Invest | Chronic inflammation involves CCL11 and IL-13 to facilitate the development of liver cirrhosis and fibrosis in chronic hepatitis B virus infection. | 2021 | Details |
| A04724 | 33527637 | Liver Int | National digestive disease specialists survey on cardiovascular risk management in non-alcoholic fatty liver disease in spanish hospitals. | 2021 | Details |
| A04725 | 33526807 | Lab Invest | NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water. | 2021 | Details |
| A04729 | 33525493 | Cells | Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations. | 2021 | Details |
| A04730 | 33525359 | Int J Mol Sci | Fatty Acids and a High-Fat Diet Induce Epithelial-Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells. | 2021 | Details |
| A04735 | 33520810 | J Diabetes Metab Disord | Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease. | 2020 | Details |
| A04736 | 33520569 | Biosci Microbiota Food Health | Correlation of gut Firmicutes/Bacteroidetes ratio with fibrosis and steatosis stratified by body mass index in patients with non-alcoholic fatty liver disease. | 2020 | Details |
| A04737 | 33520498 | Cureus | Severity of Non-B and Non-C Hepatitis Versus Hepatitis B and C Associated Chronic Liver Disease: A Retrospective, Observational, Comparative Study. | 2020 | Details |
| A04747 | 33515803 | Ann Hepatol | Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis. | 2021 | Details |
| A04749 | 33515800 | Ann Hepatol | Horizon scanning of therapeutic modalities for nonalcoholic steatohepatitis. | 2021 | Details |
| A04752 | 33515562 | Life Sci | miR-125b promotes the NF-κB-mediated inflammatory response in NAFLD via directly targeting TNFAIP3. | 2021 | Details |
| A04754 | 33515016 | Am J Clin Nutr | Food insecurity is associated with magnetic resonance-determined nonalcoholic fatty liver and liver fibrosis in low-income, middle-aged adults with and without HIV. | 2021 | Details |
| A04758 | 33513761 | Metabolites | Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: An Updated Meta-Analysis of Randomized Controlled Trials. | 2021 | Details |
| A04769 | 33511282 | Clin Exp Hepatol | SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review. | 2020 | Details |
| A04772 | 33511140 | Front Med (Lausanne) | Distinct Cause of Death Profiles of Hospitalized Non-alcoholic Fatty Liver Disease: A 10 Years' Cross-Sectional Multicenter Study in China. | 2021 | Details |
| A04779 | 33509116 | BMC Gastroenterol | Obesity interacts with hyperuricemia on the severity of non-alcoholic fatty liver disease. | 2021 | Details |
| A04781 | 33506689 | J Am Heart Assoc | Liver Fibrosis Scoring Systems as Novel Tools for Predicting Cardiovascular Outcomes in Patients Following Elective Percutaneous Coronary Intervention. | 2021 | Details |
| A04782 | 33506599 | Cancer Sci | NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice. | 2021 | Details |
| A04793 | 33505139 | World J Gastroenterol | Gut microbiota mediated molecular events and therapy in liver diseases. | 2020 | Details |
| A04796 | 33504297 | Curr Pharm Des | NAFLD: Diagnostic Algorithms for Regulating Patient Fluxes. | 2021 | Details |
| A04799 | 33501889 | Am J Physiol Gastrointest Liver Physiol | A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice. | 2021 | Details |
| A04800 | 33501884 | Am J Physiol Gastrointest Liver Physiol | Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization. | 2021 | Details |
| A04803 | 33500717 | Theranostics | Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis. | 2021 | Details |
| A04812 | 33497819 | Biochim Biophys Acta Mol Basis Dis | Non-coding RNA crosstalk with nuclear receptors in liver disease. | 2021 | Details |
| A04814 | 33497019 | Liver Int | Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real-world data analysis. | 2021 | Details |
| A04816 | 33496855 | Acta Diabetol | Lack of awareness of liver organ damage in patients with type 2 diabetes. | 2021 | Details |
| A04817 | 33495844 | Mol Med Rep | Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model. | 2021 | Details |
| A04818 | 33494735 | BMC Complement Med Ther | Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis. | 2021 | Details |
| A04819 | 33494361 | J Clin Med | Referral Patterns for Patients with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04820 | 33494295 | Cells | Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways. | 2021 | Details |
| A04822 | 33493657 | Pharmacol Res | Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. | 2021 | Details |
| A04828 | 33491665 | JCI Insight | Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. | 2021 | Details |
| A04831 | 33490936 | JHEP Rep | Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. | 2020 | Details |
| A04844 | 33486695 | Arch Pharm Res | Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. | 2021 | Details |
| A04846 | 33486083 | Clin Gastroenterol Hepatol | Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort. | 2021 | Details |
| A04849 | 33485064 | Biomed Pharmacother | Crosstalk between PPARs and gut microbiota in NAFLD. | 2021 | Details |
| A04854 | 33482026 | Aliment Pharmacol Ther | Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of gut microbiota in adult non-alcoholic fatty liver disease. | 2021 | Details |
| A04862 | 33477873 | Biomedicines | Extracellular Vesicles as Drivers of Non-Alcoholic Fatty Liver Disease: Small Particles with Big Impact. | 2021 | Details |
| A04868 | 33475559 | J Pak Med Assoc | Non-alcoholic fatty liver disease: A real threat in Pakistan. | 2020 | Details |
| A04869 | 33474981 | AJR Am J Roentgenol | Utility of Multiparametric CT for Identification of High-Risk NAFLD. | 2021 | Details |
| A04873 | 33472102 | Acta Biomater | How histopathologic changes in pediatric nonalcoholic fatty liver disease influence in vivo liver stiffness. | 2021 | Details |
| A04874 | 33471632 | Am J Physiol Gastrointest Liver Physiol | Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis? | 2021 | Details |
| A04879 | 33470379 | Arq Bras Cir Dig | BYPASS VS. SLEEVE AND ITS EFFECTS IN NON-ALCOHOLIC FATTY LIVER DISEASE: WHAT IS THE BEST TECHNIQUE? | 2021 | Details |
| A04881 | 33468357 | Ultrasound Med Biol | Non-invasive Assessment of Liver Fat in ob/ob Mice Using Ultrasound-Induced Thermal Strain Imaging and Its Correlation with Hepatic Triglyceride Content. | 2021 | Details |
| A04883 | 33467660 | Int J Mol Sci | Common Transcriptional Program of Liver Fibrosis in Mouse Genetic Models and Humans. | 2021 | Details |
| A04885 | 33467114 | Diagnostics (Basel) | Prediction of Nonalcoholic Fatty Liver Disease Using Noninvasive and Non-Imaging Procedures in Japanese Health Checkup Examinees. | 2021 | Details |
| A04886 | 33466889 | Metabolites | Two Metabolomics Phenotypes of Human Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease According to Fibrosis Severity. | 2021 | Details |
| A04887 | 33465844 | Clin Mol Hepatol | Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis. | 2021 | Details |