Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A23542 | 23696823 | PLoS One | Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis. | 2013 | Details |
| A23568 | 23666886 | Obesity (Silver Spring) | Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease. | 2013 | Details |
| A23583 | 23657151 | Curr Opin Clin Nutr Metab Care | Carbohydrate intake and nonalcoholic fatty liver disease. | 2013 | Details |
| A23584 | 23656726 | Br J Nutr | Effects of long-term administration of saturated and n-3 fatty acid-rich diets on lipid utilisation and oxidative stress in rat liver and muscle tissues. | 2013 | Details |
| A23595 | 23651738 | Toxicol Appl Pharmacol | Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. | 2013 | Details |
| A23612 | 27904876 | Postdoc J | The Mediation of Hepatic Lipogenesis Through Estrogens. | 2013 | Details |
| A23627 | 23618531 | J Nutr Biochem | Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. | 2013 | Details |
| A23639 | 23605066 | Pflugers Arch | Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation. | 2013 | Details |
| A23665 | 23585904 | PLoS One | Fructus Xanthii attenuates hepatic steatosis in rats fed on high-fat diet. | 2013 | Details |
| A23775 | 23492103 | Gut | Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. | 2013 | Details |
| A23786 | 23482247 | World J Gastroenterol | Fructose as a key player in the development of fatty liver disease. | 2013 | Details |
| A23802 | 23465592 | J Nutr Biochem | S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. | 2013 | Details |
| A23825 | 26064833 | J Lifestyle Med | Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs. | 2013 | Details |
| A23838 | 23435355 | Biochem Pharmacol | Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. | 2013 | Details |
| A23842 | 23432843 | Liver Int | GLP-1 analogue prevents NAFLD in ApoE KO mice with diet and Acrp30 knockdown by inhibiting c-JNK. | 2013 | Details |
| A23888 | 23401753 | J Obes | Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice. | 2013 | Details |
| A23898 | 23397118 | J Gastroenterol | Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. | 2013 | Details |
| A23918 | 23390127 | Hepatology | Dietary fructose in nonalcoholic fatty liver disease. | 2013 | Details |
| A23923 | 23387211 | Sichuan Da Xue Xue Bao Yi Xue Ban | [Impact of electro-acupuncture on lipid metalolism in rats with non-alcoholic fatty liver disease]. | 2012 | Details |
| A23924 | 23385644 | J Mol Med (Berl) | Lack of kinin B₁ receptor potentiates leptin action in the liver. | 2013 | Details |
| A23961 | 23348573 | Hepatology | Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor α through a sterol regulatory element-binding protein 1c-dependent mechanism in mice. | 2013 | Details |
| A23974 | 23333450 | J Hepatol | Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor. | 2013 | Details |
| A23982 | 23329013 | Dig Dis Sci | Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. | 2013 | Details |
| A24001 | 23313470 | Prostaglandins Leukot Essent Fatty Acids | Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids. | 2013 | Details |
| A24017 | 23299992 | Hepatology | Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. | 2013 | Details |
| A24036 | 23293202 | Ann Hepatol | Therapeutic effects of granulocyte-colony stimulating factor on non-alcoholic hepatic steatosis in the rat. | 2013 | Details |
| A24066 | 24648896 | Biomed Rep | Quercetin improves insulin resistance and hepatic lipid accumulation in vitro in a NAFLD cell model. | 2012 | Details |
| A24078 | 23258548 | Mol Pharmacol | 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. | 2012 | Details |
| A24088 | 23237488 | ACS Chem Biol | A liver-selective LXR inverse agonist that suppresses hepatic steatosis. | 2012 | Details |
| A24132 | 23197411 | Gut | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. | 2012 | Details |
| A24152 | 23175777 | J Lipid Res | Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat. | 2012 | Details |
| A24162 | 23165534 | Nutr Hosp | Possible molecular mechanisms soy-mediated in preventing and treating nonalcoholic fatty liver disease. | 2013 | Details |
| A24171 | 23155331 | World J Gastroenterol | PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease. | 2012 | Details |
| A24180 | 23142626 | Gastroenterology | Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. | 2012 | Details |
| A24218 | 23110104 | PLoS One | E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia. | 2012 | Details |
| A24264 | 23066040 | Cancer Res | Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. | 2012 | Details |
| A24267 | 23063693 | Biochimie | A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα. | 2012 | Details |
| A24306 | 23022226 | Biochem Pharmacol | High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload. | 2012 | Details |
| A24317 | 23002334 | World J Gastroenterol | Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis. | 2012 | Details |
| A24365 | 22964849 | Lab Invest | Stimulation of fat accumulation in hepatocytes by PGE₂-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. | 2012 | Details |
| A24382 | 22952180 | Am J Clin Nutr | Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. | 2012 | Details |
| A24386 | 22950055 | Diabetes Metab J | GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease. | 2012 | Details |
| A24419 | 22918684 | Dig Dis Sci | Dipeptidyl peptidase 4-deficient rats have improved bile secretory function in high fat diet-induced steatosis. | 2012 | Details |
| A24458 | 22876038 | World J Gastroenterol | Moro orange juice prevents fatty liver in mice. | 2012 | Details |
| A24473 | 22858825 | Mol Med Rep | Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. | 2012 | Details |
| A24501 | 22829450 | Diabetes | Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. | 2012 | Details |
| A24520 | 22819708 | Eur J Pharmacol | Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. | 2012 | Details |
| A24528 | 22806626 | Hepatology | Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. | 2012 | Details |
| A24534 | 22796155 | J Hepatol | Phenotyping the effect of diet on non-alcoholic fatty liver disease. | 2012 | Details |
| A24535 | 22795319 | Clin Res Hepatol Gastroenterol | Does fructose consumption contribute to non-alcoholic fatty liver disease? | 2012 | Details |
| A24562 | 22749135 | J Nutr Biochem | The role of dietary fatty acids in the pathology of metabolic syndrome. | 2012 | Details |
| A24567 | 22742899 | Eur J Pharmacol | Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. | 2012 | Details |
| A24595 | 22713601 | Lipids Health Dis | Fructose-rich diet leads to reduced aerobic capacity and to liver injury in rats. | 2012 | Details |
| A24669 | 22628617 | J Lipid Res | Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. | 2012 | Details |
| A24674 | 22617751 | Curr Opin Lipidol | Nonalcoholic fatty liver disease and lipids. | 2012 | Details |
| A24702 | 22583519 | Liver Int | The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver disease. | 2012 | Details |
| A24708 | 22576368 | Mol Med | Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice. | 2012 | Details |
| A24715 | 22569330 | Lipids Health Dis | Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. | 2012 | Details |
| A24722 | 22561686 | Nat Med | Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. | 2012 | Details |
| A24736 | 22546860 | J Clin Invest | The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. | 2012 | Details |
| A24785 | 22498245 | Best Pract Res Clin Endocrinol Metab | Metabolic insights from extreme human insulin resistance phenotypes. | 2012 | Details |
| A24816 | 22467759 | Exp Physiol | Food restriction and refeeding induces changes in lipid pathways and fat deposition in the adipose and hepatic tissues in rats with diet-induced obesity. | 2012 | Details |
| A24829 | 22457136 | Chin J Integr Med | Ping-tang Recipe () improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats. | 2012 | Details |
| A24831 | 22451385 | Biosci Biotechnol Biochem | Effects of lotus root (the edible rhizome of Nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice. | 2012 | Details |
| A24833 | 22449814 | Curr Opin Lipidol | Connecting mTORC1 signaling to SREBP-1 activation. | 2012 | Details |
| A24861 | 22425624 | J Hepatol | Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. | 2012 | Details |
| A24868 | 22418889 | Semin Liver Dis | Exercise and the liver: implications for therapy in fatty liver disorders. | 2012 | Details |
| A24876 | 22414386 | Toxicol Lett | Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. | 2012 | Details |
| A24894 | 22385956 | Cell | Mechanisms for insulin resistance: common threads and missing links. | 2012 | Details |
| A24986 | 22278044 | Eur J Nutr | Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model. | 2012 | Details |
| A24992 | 22271167 | Hepatology | Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. | 2012 | Details |
| A25001 | 22257474 | J Dig Dis | Liver X receptors bridge hepatic lipid metabolism and inflammation. | 2012 | Details |
| A25083 | 22183915 | Hepatology | Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver disease. | 2012 | Details |
| A25098 | 22173168 | J Hepatol | The interaction of hepatic lipid and glucose metabolism in liver diseases. | 2011 | Details |
| A25100 | 22173165 | J Hepatol | Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. | 2011 | Details |
| A25155 | 22129639 | J Nutr Biochem | The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease. | 2011 | Details |
| A25161 | 22122481 | Curr Pharm Biotechnol | Non-alcoholic steatohepatitis: new insights from OMICS studies. | 2012 | Details |
| A25220 | 22083307 | Mol Cells | Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. | 2011 | Details |
| A25236 | 22064361 | Free Radic Biol Med | Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. | 2011 | Details |
| A25283 | 22008843 | Food Funct | The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity. | 2011 | Details |
| A25338 | 21948338 | Dig Dis Sci | Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease. | 2011 | Details |
| A25351 | 21936721 | Scand J Gastroenterol | Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice. | 2011 | Details |
| A25355 | 21932408 | Hepatology | Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. | 2011 | Details |
| A25365 | 21905818 | Int J Pediatr Obes | Fatty liver disease in obese children--relation to other metabolic risk factors. | 2011 | Details |
| A25379 | 21907177 | Am J Pathol | Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. | 2011 | Details |
| A25418 | 21876629 | World J Gastroenterol | Nutritional recommendations for patients with non-alcoholic fatty liver diseases. | 2011 | Details |
| A25420 | 21875310 | Crit Rev Clin Lab Sci | Non-alcoholic fatty liver disease. | 2011 | Details |
| A25432 | 21853118 | PLoS One | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | Details |
| A25444 | 21835806 | J Gerontol A Biol Sci Med Sci | Aging is associated with a shift of fatty metabolism toward lipogenesis. | 2011 | Details |
| A25450 | 21818154 | Obesity (Silver Spring) | Perinephric and epididymal fat affect hepatic metabolism in rats. | 2011 | Details |
| A25453 | 21817060 | Am J Physiol Gastrointest Liver Physiol | Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis. | 2011 | Details |
| A25456 | 21813474 | Gut | Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. | 2011 | Details |
| A25460 | 21808028 | Proc Natl Acad Sci U S A | Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. | 2011 | Details |
| A25482 | 21781943 | J Hepatol | High fructose feeding induces copper deficiency in Sprague-Dawley rats: a novel mechanism for obesity related fatty liver. | 2011 | Details |
| A25533 | 21740407 | Br J Pharmacol | Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis. | 2012 | Details |
| A25543 | 21733326 | Br J Nutr | Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. | 2011 | Details |
| A25572 | 21703185 | J Hepatol | Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. | 2011 | Details |
| A25651 | 21593806 | Obesity (Silver Spring) | Downregulation of hepatic glucose-6-phosphatase-α in patients with hepatic steatosis. | 2011 | Details |
| A25657 | 21570964 | Exp Mol Pathol | A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. | 2011 | Details |
| A25721 | 21507897 | FASEB J | Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. | 2011 | Details |