Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A36654 | 17518368 | Hepatology | Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. | 2007 | Details |
| A36686 | 17464987 | Hepatology | CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. | 2007 | Details |
| A36688 | 17459514 | J Hepatol | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. | 2007 | Details |
| A36699 | 17436085 | Dig Dis Sci | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36704 | 17420940 | Dig Dis Sci | Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model. | 2007 | Details |
| A36717 | 17394061 | Dig Dis Sci | Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP). | 2007 | Details |
| A36720 | 17391797 | J Hepatol | The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population. | 2007 | Details |
| A36745 | 17351431 | Invest Radiol | Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging. | 2007 | Details |
| A36763 | 17313679 | Nutr Metab (Lond) | Long term highly saturated fat diet does not induce NASH in Wistar rats. | 2007 | Details |
| A36765 | 17311618 | Liver Int | Yo jyo hen shi ko, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet. | 2007 | Details |
| A36799 | 17244458 | Zhonghua Gan Zang Bing Za Zhi | [The role of apoptosis and the related genes in non-alcoholic steatohepatitis]. | 2007 | Details |
| A36801 | 17241878 | Gastroenterology | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. | 2006 | Details |
| A36886 | 17006938 | Hepatology | Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. | 2006 | Details |
| A36912 | 16953841 | Liver Int | Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis. | 2006 | Details |
| A37019 | 16706830 | J Gastroenterol Hepatol | Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency. | 2006 | Details |
| A37053 | 16574099 | Eur J Pharmacol | Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2006 | Details |
| A37091 | 16498637 | J Biochem Mol Toxicol | Glutathione-enhancing agents protect against steatohepatitis in a dietary model. | 2006 | Details |
| A37118 | 16439472 | Am J Physiol Gastrointest Liver Physiol | Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium. | 2006 | Details |
| A37157 | 16376450 | J Hepatol | Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. | 2005 | Details |
| A37182 | 19079906 | Nutr Res Rev | Therapeutic potential of curcumin in non-alcoholic steatohepatitis. | 2005 | Details |
| A37227 | 16216545 | Hepatol Res | Diagnosis of NASH using delayed parenchymal imaging of contrast ultrasound. | 2005 | Details |
| A37231 | 16214393 | Hepatol Res | The role of oxidative stress in NASH and fatty liver model. | 2005 | Details |
| A37248 | 16174657 | Gut | Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. | 2005 | Details |
| A37276 | 16085455 | Hepatol Res | The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, l-amino acid-defined diet. | 2005 | Details |
| A37540 | 15460086 | Postgrad Med | Cardiovascular risk beyond LDL-C levels. Other lipids are performers in cholesterol story. | 2004 | Details |
| A37620 | 15256362 | Am J Physiol Gastrointest Liver Physiol | Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. | 2004 | Details |
| A37721 | 15044174 | Am J Physiol Gastrointest Liver Physiol | Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. | 2004 | Details |
| A37757 | 14734794 | Exp Biol Med (Maywood) | Sex differences in choline-deficient diet-induced steatohepatitis in mice. | 2004 | Details |
| A37954 | 12687723 | Nihon Arukoru Yakubutsu Igakkai Zasshi | Clinical and pathological differences between alcoholic hepatitis and non-alcoholic steatohepatitis. | 2003 | Details |
| A38276 | 11713934 | Dig Dis Sci | Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. | 2001 | Details |
| A38320 | 11569700 | Am J Gastroenterol | Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. | 2001 | Details |
| A38621 | 10772651 | J Clin Invest | CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. | 2000 | Details |
| A42249 | 35101891 | J Immunol | Methionine- and Choline-Deficient Diet Identifies an Essential Role for DNA Methylation in Plasmacytoid Dendritic Cell Biology. | 2022 | Details |
| A42251 | 35093588 | Cell Mol Gastroenterol Hepatol | Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver. | 2022 | Details |
| A42320 | 34876963 | Oxid Med Cell Longev | Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer. | 2021 | Details |
| A42399 | 34666202 | J Proteomics | Two untargeted metabolomics reveals yogurt-associated metabolic alterations in women with multiple metabolic disorders from a randomized controlled study. | 2021 | Details |
| A42742 | 33596631 | J Biol Regul Homeost Agents | Vitamin D3 supplementation in controlling metabolic changes associated with non-alcoholic steatohepatitis. | 2021 | Details |
| A42978 | 32899741 | Life (Basel) | Fatty Liver, and Not Visceral Fat, Is More Associated with Liver Fibrosis and Diabetes in Non-Obese Japanese Individuals: A Cross-Sectional Study. | 2020 | Details |
| A43059 | 32680469 | BMC Gastroenterol | Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis. | 2020 | Details |
| A43094 | 32586106 | Antioxid Redox Signal | Phospholipase D as a Potential Modulator of Metabolic Syndrome: Impact of Functional Foods. | 2020 | Details |
| A43128 | 32490323 | Hepatol Commun | Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity. | 2020 | Details |
| A43131 | 32482717 | J Lipid Res | Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings. | 2020 | Details |
| A43135 | 32471727 | J Hepatol | MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. | 2020 | Details |
| A43389 | 31851339 | J Nutr | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. | 2020 | Details |
| A43429 | 31737665 | Biomed Res Int | Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. | 2019 | Details |
| A43551 | 31434800 | JCI Insight | Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. | 2019 | Details |
| A43698 | 31084205 | Ann Clin Biochem | The association between lecithin-cholesterol acyltransferase activity and fatty liver index. | 2019 | Details |
| A43945 | 30379616 | Annu Rev Physiol | Phospholipid Remodeling in Physiology and Disease. | 2018 | Details |
| A44235 | 31032137 | J Drug Alcohol Res | Alcohol-Induced Hepatic Steatosis: A Comparative Study to Identify Possible Indicator(s) of Alcoholic Fatty Liver Disease. | 2018 | Details |
| A44482 | 28489415 | Am J Respir Cell Mol Biol | Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis. | 2017 | Details |
| A44666 | 27639263 | Hepatology | Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile? | 2016 | Details |
| A44726 | 27534992 | J Lipid Res | Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. | 2016 | Details |
| A44779 | 27334756 | Mol Cell Biochem | Annexin A6 protein is downregulated in human hepatocellular carcinoma. | 2016 | Details |
| A44897 | 26924096 | Gastroenterology | Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis. | 2016 | Details |
| A44936 | 26699087 | Hepatology | Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. | 2016 | Details |
| A44943 | 26655287 | Curr Opin Lipidol | Choline metabolites: gene by diet interactions. | 2016 | Details |
| A45086 | 26121577 | PLoS One | Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. | 2015 | Details |
| A45297 | 25308174 | J Hepatol | Deficiency of periostin protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis. | 2014 | Details |
| A45302 | 25286440 | Gastroenterology | Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. | 2014 | Details |
| A45448 | 24511104 | J Lipid Res | PNPLA3 mediates hepatocyte triacylglycerol remodeling. | 2014 | Details |
| A45464 | 24429813 | Cell Physiol Biochem | Betaine transport in kidney and liver: use of betaine in liver injury. | 2013 | Details |
| A45550 | 23970447 | Hum Exp Toxicol | Chunggan extract (CGX), methionine-and choline-deficient (MCD) diet-induced hepatosteatosis and oxidative stress in C57BL/6 mice. | 2013 | Details |
| A45597 | 23720735 | J Biol Chem | C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. | 2013 | Details |
| A45606 | 23703836 | Hepatology | Finding the balance: the role of S-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease. | 2013 | Details |
| A45615 | 23640498 | Arterioscler Thromb Vasc Biol | Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression. | 2013 | Details |
| A45686 | 23292069 | FASEB J | Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. | 2013 | Details |
| A45763 | 22877991 | Biochim Biophys Acta | Physiological roles of phosphatidylethanolamine N-methyltransferase. | 2012 | Details |
| A45863 | 22330258 | Toxicology | Susceptibility to gold nanoparticle-induced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis. | 2012 | Details |
| A45905 | 22152250 | Zhonghua Gan Zang Bing Za Zhi | [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for the patients with nonalcoholic fatty liver disease]. | 2011 | Details |
| A45977 | 21760736 | Diabetes Metab Syndr Obes | Diet-induced metabolic hamster model of nonalcoholic fatty liver disease. | 2011 | Details |
| A46015 | 21538633 | NMR Biomed | Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study. | 2011 | Details |
| A46016 | 21538430 | Hepatology | Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. | 2011 | Details |
| A46121 | 20943461 | Hepatobiliary Pancreat Dis Int | Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice. | 2010 | Details |
| A46130 | 20860563 | Liver Int | Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis. | 2010 | Details |
| A46167 | 20633523 | J Acupunct Meridian Stud | Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis. | 2010 | Details |
| A46181 | 20520981 | Arq Gastroenterol | The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis. | 2010 | Details |
| A46189 | 20458758 | World J Gastroenterol | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease. | 2010 | Details |
| A46231 | 20156580 | Int J Biochem Cell Biol | Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. | 2010 | Details |
| A46249 | 20034047 | Hepatology | Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. | 2010 | Details |
| A46250 | 20034038 | Hepatology | Supporting evidence for natural killer T cell accumulation in progressive nonalcoholic fatty liver disease? | 2010 | Details |
| A46252 | 20008062 | J Pharmacol Exp Ther | A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. | 2009 | Details |
| A46259 | 19949375 | Lab Invest | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. | 2009 | Details |
| A46267 | 19918973 | Hepatology | Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice. | 2010 | Details |
| A46309 | 19602140 | Liver Int | Teucrium polium in prevention of steatohepatitis in rats. | 2009 | Details |
| A46313 | 19572984 | Alcohol Clin Exp Res | MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. | 2009 | Details |
| A46323 | 19549522 | Gastroenterology | c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. | 2009 | Details |
| A46326 | 19540737 | Pathophysiology | Serum cholinesterase activity in the diagnosis of nonalcoholic fatty liver disease in type 2 diabetic patients. | 2009 | Details |
| A46335 | 19466313 | Arq Gastroenterol | [Model of experimental nonalcoholic steatohepatitis from use of methionine and choline deficient diet]. | 2009 | Details |
| A46430 | 18710424 | Liver Int | Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. | 2008 | Details |
| A46454 | 18523032 | J Endocrinol | Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice. | 2008 | Details |
| A46465 | 18434432 | FASEB J | Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. | 2008 | Details |
| A46520 | 18046722 | Hepatology | Effects of rosiglitazone on methionine-choline deficient diet-induced nonalcoholic steatohepatitis. | 2007 | Details |
| A46521 | 18008034 | J Gastroenterol | The impact of visceral fat in nonalcoholic fatty liver disease: cross-sectional and longitudinal studies. | 2007 | Details |
| A46675 | 16679290 | Cell Metab | The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. | 2006 | Details |
| A46682 | 16557554 | Hepatology | COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. | 2006 | Details |
| A46695 | 16470305 | Braz J Med Biol Res | Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease. | 2006 | Details |
| A46776 | 15670659 | Alcohol | Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. | 2004 | Details |
| A46778 | 15650132 | Am J Physiol Gastrointest Liver Physiol | Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet. | 2005 | Details |
| A46779 | 15632182 | J Biol Chem | Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. | 2005 | Details |
| A46790 | 15519275 | Hepatol Res | Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitis. | 2004 | Details |