Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A24563 | 22748277 | Atherosclerosis | Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians. | 2012 | Details |
| A24566 | 22742931 | J Gastroenterol Hepatol | Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma. | 2012 | Details |
| A24628 | 22674675 | Phytother Res | Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. | 2012 | Details |
| A24708 | 22576368 | Mol Med | Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice. | 2012 | Details |
| A24732 | 22551412 | J Med Food | Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. | 2012 | Details |
| A24776 | 22509083 | World J Gastroenterol | Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome. | 2012 | Details |
| A24806 | 22469867 | Int J Mol Med | Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice. | 2012 | Details |
| A24824 | 22464551 | Nutrition | Non-alcoholic fatty liver disease in children now: lifestyle changes and pharmacologic treatments. | 2012 | Details |
| A24825 | 22462240 | J Tradit Chin Med | Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity. | 2011 | Details |
| A24827 | 22458550 | Nutr Metab (Lond) | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. | 2012 | Details |
| A24832 | 22450341 | Hormones (Athens) | Adiponectin: regulation of its production and its role in human diseases. | 2012 | Details |
| A24861 | 22425624 | J Hepatol | Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. | 2012 | Details |
| A24875 | 22414768 | J Hepatol | Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. | 2012 | Details |
| A24915 | 22364184 | J Agric Food Chem | Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways. | 2012 | Details |
| A24950 | 22326465 | J Hepatol | Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. | 2012 | Details |
| A24979 | 22285877 | Magn Reson Imaging | Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging. | 2012 | Details |
| A25035 | 22227283 | Prev Med | Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling. | 2011 | Details |
| A25045 | 22219597 | World J Gastroenterol | Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease. | 2011 | Details |
| A25049 | 22215515 | Toxicol Pathol | Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer. | 2012 | Details |
| A25113 | 22160635 | Dig Dis Sci | Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD. | 2011 | Details |
| A25133 | 22152320 | Zhonghua Gan Zang Bing Za Zhi | [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. | 2011 | Details |
| A25177 | 22110479 | Exp Diabetes Res | Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice. | 2011 | Details |
| A25199 | 22098164 | J Gastroenterol Hepatol | Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export. | 2012 | Details |
| A25206 | 22094893 | Curr Top Microbiol Immunol | Contribution of the intestinal microbiota to human health: from birth to 100 years of age. | 2013 | Details |
| A25209 | 22093454 | Liver Int | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. | 2011 | Details |
| A25222 | 22082335 | Chem Res Toxicol | Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. | 2011 | Details |
| A25241 | 22056763 | Biochim Biophys Acta | Roles of PPARs in NAFLD: potential therapeutic targets. | 2011 | Details |
| A25283 | 22008843 | Food Funct | The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity. | 2011 | Details |
| A25287 | 21994008 | Hepatology | Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. | 2012 | Details |
| A25342 | 21946918 | Mol Med Rep | Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. | 2011 | Details |
| A25343 | 21946149 | Exp Mol Pathol | Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis. | 2011 | Details |
| A25349 | 21939732 | Mol Cell Endocrinol | PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population. | 2011 | Details |
| A25351 | 21936721 | Scand J Gastroenterol | Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice. | 2011 | Details |
| A25360 | 21929649 | J Gastroenterol Hepatol | Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis. | 2012 | Details |
| A25373 | 21911890 | Ann Hepatol | Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet. | 2011 | Details |
| A25508 | 21742296 | Clin Res Hepatol Gastroenterol | Liver fibrogenesis and metabolic factors. | 2011 | Details |
| A25528 | 21745271 | Liver Int | Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. | 2011 | Details |
| A25542 | 21733354 | Chang Gung Med J | Disrupted hepatic adiponectin signaling impairs liver regeneration of steatotic rats. | 2011 | Details |
| A25572 | 21703185 | J Hepatol | Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. | 2011 | Details |
| A25629 | 21626400 | J Physiol Biochem | Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes. | 2011 | Details |
| A25630 | 21624329 | Zhonghua Yu Fang Yi Xue Za Zhi | [Effects of soybean isoflavone on liver lipid metabolism in nonalcoholic fatty liver rats]. | 2011 | Details |
| A25639 | 21616061 | Biochem Biophys Res Commun | Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease. | 2011 | Details |
| A25696 | 21530275 | Bioorg Med Chem | Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. | 2011 | Details |
| A25697 | 21529810 | Atherosclerosis | PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH. | 2011 | Details |
| A25721 | 21507897 | FASEB J | Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. | 2011 | Details |
| A25774 | 21474829 | Arterioscler Thromb Vasc Biol | Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. | 2011 | Details |
| A25777 | 21470125 | Curr Pharm Biotechnol | Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). | 2012 | Details |
| A25779 | 21464822 | Lab Invest | Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice. | 2011 | Details |
| A25780 | 21463618 | Eur J Pharmacol | A novel agonist of PPAR-γ based on barbituric acid alleviates the development of non-alcoholic fatty liver disease by regulating adipocytokine expression and preventing insulin resistance. | 2011 | Details |
| A25797 | 22813407 | Diabetes Metab Syndr | Association of nonalcoholic fatty liver disease with metabolic syndrome in Indian population. | 2012 | Details |
| A25799 | 21448953 | J Magn Reson Imaging | Effect of disease progression on liver apparent diffusion coefficient values in a murine model of NASH at 11.7 Tesla MRI. | 2011 | Details |
| A25845 | 21401612 | J Pharm Pharmacol | Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis. | 2011 | Details |
| A25859 | 21382273 | J Biol Regul Homeost Agents | Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease. | 2011 | Details |
| A25860 | 21382219 | Br J Nutr | Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A25861 | 21382165 | Liver Int | A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet. | 2011 | Details |
| A25875 | 21364286 | J Clin Invest | Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. | 2011 | Details |
| A25897 | 21346097 | J Nutr | PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. | 2011 | Details |
| A25905 | 21339203 | Gut | The role of apolipoprotein A5 in non-alcoholic fatty liver disease. | 2011 | Details |
| A25920 | 21327395 | Cell Tissue Res | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. | 2011 | Details |
| A25921 | 21325464 | J Clin Endocrinol Metab | Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction. | 2011 | Details |
| A25955 | 21269482 | Lipids Health Dis | Comparison of dietary control and atorvastatin on high fat diet induced hepatic steatosis and hyperlipidemia in rats. | 2011 | Details |
| A25976 | 21246004 | World J Gastroenterol | Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. | 2011 | Details |
| A25977 | 21245286 | Drug Metab Dispos | Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis. | 2011 | Details |
| A26005 | 21216282 | Biochim Biophys Acta | Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. | 2011 | Details |
| A26032 | 21184786 | J Hepatol | Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. | 2010 | Details |
| A26058 | 21155004 | World J Gastroenterol | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases. | 2010 | Details |
| A26070 | 21145833 | J Hepatol | Direct effects of iodothyronines on excess fat storage in rat hepatocytes. | 2010 | Details |
| A26086 | 21128245 | Int J Cancer | Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis. | 2011 | Details |
| A26089 | 21126079 | J Agric Food Chem | Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. | 2010 | Details |
| A26120 | 21068129 | Gut | Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. | 2010 | Details |
| A26121 | 21067942 | Trends Endocrinol Metab | Fructose induced lipogenesis: from sugar to fat to insulin resistance. | 2010 | Details |
| A26157 | 20981217 | Gut Liver | Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study. | 2010 | Details |
| A26169 | 20965162 | Eur J Pharmacol | The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats. | 2010 | Details |
| A26183 | 20943079 | Zhonghua Gan Zang Bing Za Zhi | [Effect of body weight mass and its change on the incidence of nonalcoholic fatty liver disease]. | 2010 | Details |
| A26190 | 20938947 | Hepatology | Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. | 2010 | Details |
| A26196 | 20929443 | Clin Sci (Lond) | Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. | 2011 | Details |
| A26202 | 20890895 | Hepatology | Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter. | 2010 | Details |
| A26226 | 20868235 | Biol Chem | Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice. | 2010 | Details |
| A26245 | 20842602 | Swiss Med Wkly | Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. | 2010 | Details |
| A26252 | 20836990 | Biochem Biophys Res Commun | Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice. | 2010 | Details |
| A26257 | 20825652 | BMC Gastroenterol | Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. | 2010 | Details |
| A26259 | 20818807 | World J Gastroenterol | Obstructive sleep apnea syndrome and fatty liver: association or causal link? | 2010 | Details |
| A26273 | 20803499 | Hepatology | A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. | 2010 | Details |
| A26275 | 20801631 | J Nutr Biochem | An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. | 2010 | Details |
| A26298 | 20687969 | Br J Nutr | The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. | 2010 | Details |
| A26301 | 20683463 | Eur J Clin Nutr | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Details |
| A26304 | 20675007 | J Hepatol | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. | 2010 | Details |
| A26305 | 20673376 | Br J Nutr | A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat-high-sucrose diet-fed rats: possible implication of the sirtuin pathway. | 2010 | Details |
| A26369 | 20579864 | J Nutr Biochem | Serum adipocyte-specific fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects. | 2010 | Details |
| A26386 | 20553760 | Prog Lipid Res | Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease. | 2010 | Details |
| A26403 | 20509914 | BMC Gastroenterol | Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | 2010 | Details |
| A26417 | 20492333 | J Gastroenterol Hepatol | Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. | 2010 | Details |
| A26476 | 20416398 | Biochim Biophys Acta | Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. | 2010 | Details |
| A26496 | 20392873 | J Clin Endocrinol Metab | Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease. | 2010 | Details |
| A26515 | 20370732 | J Gastroenterol Hepatol | Electron microscopic findings in non-alcoholic fatty liver disease: is there a difference between hepatosteatosis and steatohepatitis? | 2010 | Details |
| A26526 | 20037278 | Korean J Hepatol | Current status of liver disease in Korea: nonalcoholic fatty liver disease. | 2009 | Details |
| A26528 | 20357081 | J Nutr | Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. | 2010 | Details |
| A26543 | 20236931 | J Biol Chem | Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. | 2010 | Details |
| A26558 | 20206411 | Gastroenterol Hepatol | [Obesity and liver disease]. | 2010 | Details |
| A26559 | 20206399 | J Hepatol | Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. | 2010 | Details |