Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A44710 | 27635189 | Oxid Med Cell Longev | Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice. | 2016 | Details |
| A44726 | 27534992 | J Lipid Res | Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. | 2016 | Details |
| A44730 | 27511913 | Toxicol Appl Pharmacol | Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β. | 2016 | Details |
| A44873 | 27013235 | Genes Dev | The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. | 2016 | Details |
| A44941 | 26664429 | J Res Med Sci | Resveratrol and liver: A systematic review. | 2015 | Details |
| A45016 | 26435214 | Toxicol Appl Pharmacol | Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. | 2015 | Details |
| A45086 | 26121577 | PLoS One | Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. | 2015 | Details |
| A45262 | 25483735 | J Surg Res | BH3-only proteins contribute to steatotic liver ischemia-reperfusion injury. | 2014 | Details |
| A45312 | 25230688 | Mol Med Rep | Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy. | 2014 | Details |
| A45354 | 25065906 | Hepatology | Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease. | 2014 | Details |
| A45385 | 24879802 | J Lipid Res | Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation. | 2014 | Details |
| A45388 | 24859739 | J Lipid Res | Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. | 2014 | Details |
| A45396 | 24822223 | Biomed Res Int | Melatonin in the regulation of liver steatosis following prenatal glucocorticoid exposure. | 2014 | Details |
| A45428 | 24678423 | Int J Hepatol | Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver. | 2014 | Details |
| A45501 | 24280056 | Endocrinology | Testosterone replacement ameliorates nonalcoholic fatty liver disease in castrated male rats. | 2013 | Details |
| A45528 | 24129500 | Eur J Nutr | Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway. | 2013 | Details |
| A45537 | 24065684 | Genet Mol Res | Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population. | 2013 | Details |
| A45565 | 23861552 | J Lipid Res | Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36. | 2013 | Details |
| A45572 | 23837135 | Clin Mol Hepatol | Noninvasive markers: a double-edged sword that stratifies nonalcoholic steatohepatitis. | 2013 | Details |
| A45597 | 23720735 | J Biol Chem | C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. | 2013 | Details |
| A45645 | 23482364 | Georgian Med News | [Role of proapoptotic p-53 factor in pathogenesis of nonalcoholic hepatosteatosis]. | 2013 | Details |
| A45677 | 23316217 | PPAR Res | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. | 2012 | Details |
| A45694 | 23252777 | Aliment Pharmacol Ther | Commentary: assessment of non-alcoholic fatty liver disease using serum total cell death and apoptosis markers--authors' reply. | 2013 | Details |
| A45695 | 23252776 | Aliment Pharmacol Ther | Commentary: assessment of non-alcoholic fatty liver disease using serum total cell death and apoptosis markers. | 2013 | Details |
| A45706 | 23175343 | Postepy Hig Med Dosw (Online) | [Role of sphingolipids in digestive system]. | 2012 | Details |
| A45722 | 23093702 | Endocrinology | Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. | 2012 | Details |
| A45742 | 22992889 | Endocrine | Ghrelin: a new treatment for non-alcoholic fatty liver disease? | 2012 | Details |
| A45743 | 22991197 | Hepatology | Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. | 2013 | Details |
| A45751 | 22960075 | Am J Pathol | The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis. | 2012 | Details |
| A45805 | 22648736 | J Cachexia Sarcopenia Muscle | Consilience in sarcopenia of cirrhosis. | 2012 | Details |
| A45821 | 22531045 | Drug Metab Dispos | In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties. | 2012 | Details |
| A45863 | 22330258 | Toxicology | Susceptibility to gold nanoparticle-induced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis. | 2012 | Details |
| A45913 | 22103615 | Biomark Med | Reliability of caspase activity as a biomarker of hepatic apoptosis in nonalcoholic fatty liver disease. | 2011 | Details |
| A45959 | 21856859 | J Pharmacol Exp Ther | Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. | 2011 | Details |
| A45971 | 21772667 | Mediators Inflamm | Foxp3 expression in liver correlates with the degree but not the cause of inflammation. | 2011 | Details |
| A45982 | 21745285 | Liver Int | Dual role of survivin in non-alcoholic fatty liver disease. | 2011 | Details |
| A46001 | 21654881 | Am J Transl Res | Lipotoxicity in HepG2 cells triggered by free fatty acids. | 2011 | Details |
| A46089 | 21160986 | World J Hepatol | Liver function tests: Association with cardiovascular outcomes. | 2010 | Details |
| A46117 | 20967760 | Hepatology | Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. | 2010 | Details |
| A46186 | 20470896 | Biochim Biophys Acta | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. | 2010 | Details |
| A46231 | 20156580 | Int J Biochem Cell Biol | Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. | 2010 | Details |
| A46259 | 19949375 | Lab Invest | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. | 2009 | Details |
| A46287 | 19769633 | Aliment Pharmacol Ther | Systematic review: caspase-cleaved fragments of cytokeratin 18 - the promises and challenges of a biomarker for chronic liver disease. | 2009 | Details |
| A46292 | 19739236 | Hepatology | Chronically inflamed livers up-regulate expression of inhibitory B7 family members. | 2009 | Details |
| A46376 | 19207680 | J Gastroenterol Hepatol | Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. | 2009 | Details |
| A46430 | 18710424 | Liver Int | Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. | 2008 | Details |
| A46447 | 18566043 | Drug Metab Dispos | The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. | 2008 | Details |
| A46522 | 17979073 | Semin Liver Dis | Endoplasmic reticulum stress and liver injury. | 2007 | Details |
| A46525 | 17963745 | Exp Mol Pathol | M-30 and 4HNE are sequestered in different aggresomes in the same hepatocytes. | 2007 | Details |
| A46551 | 17668872 | Hepatology | Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. | 2007 | Details |
| A46555 | 17661402 | Hepatology | A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury. | 2007 | Details |
| A46586 | 17431009 | Endocrinology | Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. | 2007 | Details |
| A46602 | 17355088 | Semin Diagn Pathol | Alcoholic liver disease. | 2007 | Details |
| A46641 | 16952562 | Gastroenterology | Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. | 2006 | Details |
| A46694 | 16471264 | J Soc Biol | [Experimental modulation of apoptosis: physiopathological and therapeutic targets]. | 2005 | Details |
| A46714 | 16269465 | Endocrinology | Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. | 2005 | Details |
| A46725 | 16175608 | Hepatology | Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. | 2005 | Details |
| A46773 | 15703606 | Curr Opin Gastroenterol | Innate immunity in the liver. | 2003 | Details |
| A46801 | 15331066 | Clin Liver Dis | Mitochondria in nonalcoholic fatty liver disease. | 2004 | Details |
| A46884 | 11447019 | Am J Physiol Gastrointest Liver Physiol | Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. | 2001 | Details |
| A46885 | 11391044 | Alcohol Clin Exp Res | Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. | 2001 | Details |
| A46899 | 10811531 | Cell Biol Toxicol | Hepatotoxicity due to mitochondrial dysfunction. | 1999 | Details |
| A46957 | 32544093 | JCI Insight | Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms. | 2020 | Details |
| A46985 | 31265202 | IUBMB Life | Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling. | 2019 | Details |
| A47009 | 30179264 | Hepatology | Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. | 2019 | Details |
| A47013 | 30071471 | Redox Biol | Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. | 2018 | Details |
| A47022 | 29352167 | Sci Rep | SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice. | 2018 | Details |
| A47035 | 28689299 | J Mol Med (Berl) | 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. | 2017 | Details |
| A47038 | 28500689 | IUBMB Life | Blockade of hedgehog pathway is required for the protective effects of magnesium isoglycyrrhizinate against ethanol-induced hepatocyte steatosis and apoptosis. | 2017 | Details |
| A47046 | 28112200 | Sci Rep | Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease. | 2017 | Details |
| A47053 | 27821289 | J Nutr Biochem | Evaluating the effects of refined carbohydrate and fat diets with acute ethanol consumption using a mouse model of alcoholic liver injury. | 2016 | Details |
| A47055 | 27746183 | Am J Pathol | Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury. | 2016 | Details |
| A47067 | 27044810 | Biomed Pharmacother | Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. | 2016 | Details |
| A47088 | 26459052 | Int Immunopharmacol | Ligustrazine prevents alcohol-induced liver injury by attenuating hepatic steatosis and oxidative stress. | 2015 | Details |
| A47093 | 26099526 | Gastroenterology | Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. | 2015 | Details |
| A47106 | 25892964 | Int J Biol Sci | The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. | 2015 | Details |
| A47118 | 25622859 | J Nutr Biochem | Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. | 2014 | Details |
| A47121 | 25582105 | J Hepatol | Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. | 2015 | Details |
| A47125 | 25543082 | J Hepatol | Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. | 2014 | Details |
| A47129 | 25455889 | Food Chem Toxicol | Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | 2014 | Details |
| A47133 | 25399514 | J Thromb Haemost | Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells. | 2014 | Details |
| A47138 | 25278688 | World J Gastroenterol | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. | 2014 | Details |
| A47157 | 24740309 | PLoS One | Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. | 2014 | Details |
| A47160 | 24713392 | Am J Pathol | M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease. | 2014 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A47191 | 23682678 | Liver Int | Circulating MicroRNAs as potential biomarkers for alcoholic steatohepatitis. | 2013 | Details |
| A47196 | 23337955 | Int J Mol Med | Analysis of differentially expressed genes and microRNAs in alcoholic liver disease. | 2013 | Details |
| A47210 | 22841474 | Am J Pathol | Epigenetic regulation of miR-34a expression in alcoholic liver injury. | 2012 | Details |
| A47226 | 22273278 | Alcohol Clin Exp Res | Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation. | 2012 | Details |
| A47247 | 21519326 | Lab Invest | The nuclear receptor CAR modulates alcohol-induced liver injury. | 2011 | Details |
| A47252 | 21386907 | PLoS One | Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. | 2011 | Details |
| A47260 | 20659474 | Gastroenterology | Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. | 2010 | Details |
| A47276 | 19606259 | J Biomed Biotechnol | Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. | 2009 | Details |
| A47283 | 19208340 | Gastroenterology | Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. | 2009 | Details |
| A47290 | 19003881 | Hepatology | Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. | 2008 | Details |
| A47309 | 17850215 | Alcohol Clin Exp Res | Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. | 2007 | Details |
| A47312 | 17616758 | Am J Clin Nutr | Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. | 2007 | Details |
| A47313 | 17544978 | Clin Liver Dis | Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. | 2007 | Details |
| A47326 | 16958678 | J Gastroenterol Hepatol | Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. | 2006 | Details |
| A47335 | 16227360 | Gut | Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. | 2005 | Details |