Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A25723 | 21504366 | Antioxid Redox Signal | Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. | 2011 | Details |
| A25753 | 21479224 | PLoS One | Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation. | 2011 | Details |
| A25835 | 21412813 | Hepatology | Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway. | 2011 | Details |
| A25873 | 21367948 | Am J Clin Nutr | Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. | 2011 | Details |
| A25876 | 21364120 | Am J Physiol Endocrinol Metab | Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice. | 2011 | Details |
| A25890 | 21350190 | Am J Physiol Gastrointest Liver Physiol | Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model. | 2011 | Details |
| A25899 | 21343633 | J Lipid Res | Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. | 2011 | Details |
| A25961 | 21261727 | J Gastroenterol Hepatol | Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model. | 2011 | Details |
| A25973 | 21250982 | Eur J Clin Invest | Altered distribution of caveolin-1 in early liver steatosis. | 2011 | Details |
| A26005 | 21216282 | Biochim Biophys Acta | Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. | 2011 | Details |
| A26056 | 21157426 | Int J Obes (Lond) | Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism. | 2010 | Details |
| A26071 | 21145829 | J Hepatol | Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice. | 2010 | Details |
| A26093 | 21115542 | Gut | Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. | 2010 | Details |
| A26108 | 21084751 | J Clin Invest | Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. | 2010 | Details |
| A26109 | 21079772 | PLoS One | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | Details |
| A26118 | 21071306 | Orv Hetil | [Fatty liver and global cardiometabolic risk]. | 2010 | Details |
| A26121 | 21067942 | Trends Endocrinol Metab | Fructose induced lipogenesis: from sugar to fat to insulin resistance. | 2010 | Details |
| A26196 | 20929443 | Clin Sci (Lond) | Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. | 2011 | Details |
| A26240 | 20847296 | J Lipid Res | Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice. | 2010 | Details |
| A26243 | 20845385 | Biotechnol J | Hepatoprotective effect of oleuropein in mice: mechanisms uncovered by gene expression profiling. | 2010 | Details |
| A26249 | 20842026 | Curr Opin Clin Nutr Metab Care | Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data. | 2010 | Details |
| A26273 | 20803499 | Hepatology | A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. | 2010 | Details |
| A26298 | 20687969 | Br J Nutr | The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. | 2010 | Details |
| A26318 | 20655714 | J Nutr Biochem | Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. | 2010 | Details |
| A26329 | 20645852 | Annu Rev Nutr | The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. | 2010 | Details |
| A26352 | 20606731 | Int J Clin Exp Pathol | Expression of fatty acid synthase in nonalcoholic fatty liver disease. | 2010 | Details |
| A26358 | 20600015 | Gastroenterology | Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. | 2010 | Details |
| A26400 | 20518077 | World J Gastroenterol | Soft drinks consumption and nonalcoholic fatty liver disease. | 2010 | Details |
| A26437 | 20460921 | Dig Dis | Endocannabinoids and their role in fatty liver disease. | 2010 | Details |
| A26443 | 20460915 | Dig Dis | Bile acids as regulators of hepatic lipid and glucose metabolism. | 2010 | Details |
| A26451 | 20460907 | Dig Dis | Environmental and genetic determinants of fatty liver in humans. | 2010 | Details |
| A26517 | 20370677 | Curr Pharm Des | Insulin resistance in nonalcoholic fatty liver disease. | 2010 | Details |
| A26525 | 20368739 | Nat Rev Gastroenterol Hepatol | The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. | 2010 | Details |
| A26528 | 20357081 | J Nutr | Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. | 2010 | Details |
| A26537 | 20303728 | J Nutr Biochem | Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. | 2010 | Details |
| A26557 | 20207596 | Dig Liver Dis | From the metabolic syndrome to NAFLD or vice versa? | 2010 | Details |
| A26601 | 20112035 | Amino Acids | Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar. | 2010 | Details |
| A26670 | 20015565 | J Hepatol | The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status. | 2009 | Details |
| A26693 | 19945407 | Cell Metab | Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. | 2009 | Details |
| A26698 | 19937697 | Hepatology | The plasma lipidomic signature of nonalcoholic steatohepatitis. | 2009 | Details |
| A26703 | 19929925 | J Gastroenterol Hepatol | Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis. | 2009 | Details |
| A26714 | 19913842 | Metabolism | Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. | 2009 | Details |
| A26720 | 19900166 | Clin Sci (Lond) | Hypoxia and non-alcoholic fatty liver disease. | 2009 | Details |
| A26753 | 19832698 | Clin Sci (Lond) | Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. | 2009 | Details |
| A26773 | 19816994 | Hepatology | Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. | 2009 | Details |
| A26785 | 19788606 | J Gastroenterol Hepatol | Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice. | 2009 | Details |
| A26804 | 19751410 | Ann N Y Acad Sci | From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis. | 2009 | Details |
| A26820 | 19724016 | Am J Physiol Endocrinol Metab | Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. | 2009 | Details |
| A26909 | 19556020 | J Hepatol | Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. | 2009 | Details |
| A26977 | 19423319 | J Nutr Biochem | Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db/db mice. | 2009 | Details |
| A26989 | 19396962 | Curr Opin Gastroenterol | Recent advances in nonalcoholic fatty liver disease. | 2009 | Details |
| A27011 | 19359149 | Nutr Metab Cardiovasc Dis | Hepatic lipid metabolism and non-alcoholic fatty liver disease. | 2009 | Details |
| A27044 | 19282820 | Obesity (Silver Spring) | Diabetes of the liver: the link between nonalcoholic fatty liver disease and HFCS-55. | 2009 | Details |
| A27054 | 19254570 | Cell Metab | The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. | 2009 | Details |
| A27060 | 19243311 | Clin Sci (Lond) | Metabolic disturbances in non-alcoholic fatty liver disease. | 2009 | Details |
| A27088 | 19195631 | Diabetes Metab | The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. | 2008 | Details |
| A27093 | 19195625 | Diabetes Metab | The role of the lipogenic pathway in the development of hepatic steatosis. | 2008 | Details |
| A27100 | 19177596 | Hepatology | Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. | 2009 | Details |
| A27155 | 19072834 | Hepatology | Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. | 2009 | Details |
| A27199 | 19001666 | J Lipid Res | Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. | 2008 | Details |
| A27203 | 18990087 | Biochem J | Viral hepatitis and fatty liver disease: how an unwelcome guest makes pâté of the host. | 2008 | Details |
| A27223 | 18956291 | Semin Liver Dis | Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. | 2008 | Details |
| A27226 | 18950580 | Med Sci (Paris) | [Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP]. | 2008 | Details |
| A27255 | 18824034 | Prog Lipid Res | Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). | 2008 | Details |
| A27338 | 18617560 | J Physiol | Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | 2008 | Details |
| A27385 | 18501116 | Acta Pharmacol Sin | Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. | 2008 | Details |
| A27421 | 18417155 | Life Sci | The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. | 2008 | Details |
| A27433 | 18395289 | J Hepatol | Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. | 2008 | Details |
| A27434 | 18395287 | J Hepatol | Fructose consumption as a risk factor for non-alcoholic fatty liver disease. | 2008 | Details |
| A27457 | 18349115 | Am J Physiol Endocrinol Metab | A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels. | 2008 | Details |
| A27459 | 18346305 | Br J Nutr | Dietary single cell protein reduces fatty liver in obese Zucker rats. | 2008 | Details |
| A27505 | 18242210 | Gastroenterology | Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. | 2007 | Details |
| A27516 | 18218340 | Trends Mol Med | Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. | 2008 | Details |
| A27635 | 17868330 | J Gastroenterol Hepatol | Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. | 2007 | Details |
| A27657 | 17716660 | FEBS Lett | Role of ChREBP in hepatic steatosis and insulin resistance. | 2007 | Details |
| A27662 | 17567459 | J Gastroenterol Hepatol | Role of mitochondria in non-alcoholic fatty liver disease. | 2007 | Details |
| A27749 | 17526931 | J Biol Chem | Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. | 2007 | Details |
| A27931 | 16968800 | J Clin Endocrinol Metab | Review: The role of insulin resistance in nonalcoholic fatty liver disease. | 2006 | Details |
| A28049 | 16595594 | J Clin Endocrinol Metab | Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study. | 2006 | Details |
| A28072 | 16516152 | Biochem Biophys Res Commun | Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. | 2006 | Details |
| A28086 | 16485039 | J Clin Invest | Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. | 2006 | Details |
| A28219 | 16095853 | J Ethnopharmacol | Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. | 2005 | Details |
| A28270 | 15864352 | J Clin Invest | Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. | 2005 | Details |
| A28271 | 15864343 | J Clin Invest | Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. | 2005 | Details |
| A28362 | 15489564 | Eur J Gastroenterol Hepatol | Non-alcoholic steatohepatitis. | 2004 | Details |
| A28451 | 14631324 | Diabetes Metab | Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. | 2003 | Details |
| A28672 | 35162986 | Int J Mol Sci | Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease. | 2022 | Details |
| A28715 | 35102596 | Hepatology | Discovery of a INSIG binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting SREBP-mediated lipogenesis. | 2022 | Details |
| A28755 | 35058729 | J Ginseng Res | Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis. | 2021 | Details |
| A28852 | 34910547 | Sci Transl Med | β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. | 2021 | Details |
| A28895 | 34855620 | J Clin Invest | Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. | 2022 | Details |
| A28983 | 34741448 | Hepatol Commun | Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. | 2021 | Details |
| A29063 | 34638751 | Int J Mol Sci | Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes. | 2021 | Details |
| A29086 | 34603061 | Front Pharmacol | Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. | 2021 | Details |
| A29664 | 33718362 | Front Cell Dev Biol | The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes. | 2021 | Details |
| A29736 | 33604255 | J Clin Transl Hepatol | New Drugs on the Block-Emerging Treatments for Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30277 | 32712104 | Gastroenterology | FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs. | 2020 | Details |
| A30344 | 32612285 | Lab Invest | Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice. | 2020 | Details |
| A30722 | 31909359 | Hepatol Commun | Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model. | 2019 | Details |
| A31229 | 31001415 | F1000Res | Recent advances in managing/understanding the metabolic syndrome. | 2019 | Details |