Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46818 | 14720455 | Curr Gastroenterol Rep | New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. | 2004 | Details |
| A46822 | 14653214 | Rinsho Byori | [Laboratory data for assessment of nutrition in liver disease--with special reference to alcoholic hepatitis and nonalcoholic steatohepatitis (NASH)]. | 2003 | Details |
| A46859 | 12417056 | J Cell Mol Med | Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet. | 2003 | Details |
| A46889 | 11296700 | Semin Liver Dis | Animal models of steatosis. | 2001 | Details |
| A47036 | 28667706 | Pathol Int | An autopsy case of non-traumatic fat embolism syndrome. | 2017 | Details |
| A47189 | 23707365 | J Hepatol | ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. | 2013 | Details |
| A47216 | 22532405 | Mol Biosyst | Metabolic profiling of an alcoholic fatty liver in zebrafish (Danio rerio). | 2012 | Details |
| A47240 | 21763219 | J Chromatogr B Analyt Technol Biomed Life Sci | Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. | 2011 | Details |
| A47241 | 21708146 | Exp Mol Pathol | Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1 month using the rat intragastric tube feeding model. | 2011 | Details |
| A47284 | 19170661 | Alcohol Clin Exp Res | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Details |
| A47299 | 18498552 | Alcohol Clin Exp Res | Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. | 2008 | Details |
| A47312 | 17616758 | Am J Clin Nutr | Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. | 2007 | Details |
| A47340 | 15826726 | J Hepatol | Hepatic phospholipids in alcoholic liver disease assessed by proton-decoupled 31P magnetic resonance spectroscopy. | 2005 | Details |
| A47355 | 12940921 | Aliment Pharmacol Ther | Review article: Nutritional therapy in alcoholic liver disease. | 2003 | Details |
| A47358 | 12711653 | Alcohol Alcohol | Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine. | 2003 | Details |
| A47368 | 11762137 | Pathol Biol (Paris) | Alcoholic liver injury: pathogenesis and therapy in 2001. | 2001 | Details |
| A47371 | 11320206 | Proc Natl Acad Sci U S A | Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. | 2001 | Details |
| A47373 | 11268819 | Am J Addict | Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. | 2001 | Details |
| A47380 | 10397283 | Alcohol Clin Exp Res | Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. | 1999 | Details |
| A47398 | 9309314 | Alcohol Clin Exp Res | Choline deficiency augments and antibody to tumor necrosis factor-alpha attenuates endotoxin-induced hepatic injury. | 1997 | Details |
| A47400 | 9278563 | J Nutr | Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. | 1997 | Details |
| A47405 | 9113278 | Alcohol Clin Exp Res | Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. | 1997 | Details |
| A47406 | 9364195 | Life Sci | Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol. | 1997 | Details |
| A47419 | 8583149 | J Hepatol | Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. | 1995 | Details |
| A47447 | 8403799 | Clin Sci (Lond) | Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis. | 1993 | Details |
| A47467 | 1770192 | J Am Coll Nutr | Alcohol, liver, and nutrition. | 1991 | Details |
| A47475 | 2258155 | Hepatology | Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. | 1990 | Details |
| A47487 | 2480864 | Clin Ter | [Alcoholic liver diseases and their treatment]. | 1989 | Details |
| A47558 | 6492454 | Nihon Shokakibyo Gakkai Zasshi | [Serum cholinesterase activity in non-alcoholic fatty liver. Effect of obesity on the activity and role of its measurement in the differential diagnosis in chronic hepatitis]. | 1984 | Details |
| A47575 | 6884708 | Gastroenterology | In vivo evaluation of lipoprotein cholesterol ester metabolism in patients with liver disease. | 1983 | Details |
| A47587 | 6840680 | Hepatology | Plasma lipid and lipoprotein response to fat feeding in alcoholic liver disease. | 1983 | Details |
| A47605 | 35202510 | Hepatol Commun | Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models. | 2022 | Details |
| A47656 | 34147666 | Prostaglandins Other Lipid Mediat | Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36. | 2021 | Details |
| A47706 | 33293768 | J Clin Biochem Nutr | Trans-portal hepatic infusion of cultured bone marrow-derived mesenchymal stem cells in a steatohepatitis murine model. | 2020 | Details |
| A47784 | 31974614 | Mol Med Rep | Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells. | 2019 | Details |
| A47827 | 31281379 | Stem Cells Int | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis. | 2019 | Details |
| A47887 | 30019784 | Clin Exp Pharmacol Physiol | "Extracellular matrix remodelling in the liver of rats subjected to dietary choline deprivation and/or thioacetamide administration". | 2018 | Details |
| A47982 | 27425465 | J Steroid Biochem Mol Biol | Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension. | 2016 | Details |
| A48006 | 26781175 | Mol Med Rep | TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice. | 2016 | Details |
| A48048 | 25715168 | J Interferon Cytokine Res | Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model. | 2015 | Details |
| A48084 | 24595862 | Eur J Prev Cardiol | Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris. | 2014 | Details |
| A48088 | 24445078 | J Nutr Biochem | Sesame oil attenuates nutritional fibrosing steatohepatitis by modulating matrix metalloproteinases-2, 9 and PPAR-γ. | 2013 | Details |
| A48092 | 24204981 | PLoS One | Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. | 2013 | Details |
| A48120 | 22556147 | Am J Physiol Gastrointest Liver Physiol | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2012 | Details |
| A48149 | 21292266 | Atherosclerosis | Electronegative low-density lipoprotein: origin and impact on health and disease. | 2011 | Details |
| A48159 | 21068006 | J Lipid Res | Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo. | 2010 | Details |
| A48172 | 20697377 | Lab Invest | Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. | 2010 | Details |
| A48182 | 20529882 | J Lipid Res | Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver. | 2010 | Details |
| A48188 | 20223120 | Zhonghua Yi Xue Za Zhi | [Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet]. | 2009 | Details |
| A48197 | 20008134 | Am J Pathol | Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice. | 2009 | Details |
| A48200 | 19947262 | Zhongguo Zhen Jiu | [Observation on therapeutic effect of acupuncture for treatment of patients with nonalcoholic steatohepatitis]. | 2009 | Details |
| A48203 | 19901911 | Lab Invest | Curcumin limits the fibrogenic evolution of experimental steatohepatitis. | 2009 | Details |
| A48211 | 19587308 | Radiology | Early detection of steatohepatitis in fatty rat liver by using MR elastography. | 2009 | Details |
| A48275 | 17682318 | J Med | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis. | 2003 | Details |
| A48331 | 16344599 | Alcohol Clin Exp Res | Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. | 2005 | Details |
| A48353 | 15588779 | Hepatol Res | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis. | 2004 | Details |
| A48401 | 12452368 | Dig Dis Sci | Effect of ursodeoxycholic acid on hepatic steatosis in rats. | 2002 | Details |
| A48412 | 12073774 | In Vivo | Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats. | 2003 | Details |
| A48468 | 8942745 | Gastroenterology | Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. | 1996 | Details |
| A48483 | 2625817 | Nihon Hinyokika Gakkai Zasshi | [Liver disorder owing to estrogen therapy in prostatic cancer, examined histopathologically in six autopsy cases]. | 1989 | Details |
| A48486 | 3605026 | Am J Gastroenterol | Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis. | 1987 | Details |
| A48536 | 34516526 | Medicine (Baltimore) | The association between sarcopenia and endotoxin in patients with alcoholic cirrhosis. | 2021 | Details |
| A48550 | 34243946 | Life Sci | Retraction notice to "Role of hepatic neuropeptide Y-Y1 receptors in a methionine- cholinedeficient model of non-alcoholic steatohepatitis" [Life Sci. 245 (2020) 117356]. | 2021 | Details |
| A48572 | 33819305 | PLoS One | Correction: The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A48580 | 33679410 | Front Pharmacol | Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis. | 2021 | Details |
| A48591 | 33477615 | Antioxidants (Basel) | The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial. | 2021 | Details |
| A48594 | 33426525 | Brain Commun | Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation. | 2020 | Details |
| A48645 | 32492766 | Clin Mol Hepatol | Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis. | 2020 | Details |
| A48652 | 32329946 | Liver Int | A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. | 2020 | Details |
| A48658 | 32123215 | Sci Rep | Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis. | 2020 | Details |
| A48692 | 31401465 | Eur J Med Chem | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. | 2019 | Details |
| A48695 | 31376210 | FEBS Open Bio | A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity. | 2019 | Details |
| A48759 | 29518452 | J Hepatol | Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma. | 2018 | Details |
| A48772 | 29246445 | Biochim Biophys Acta Mol Basis Dis | Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. | 2017 | Details |
| A48828 | 27439970 | Clin Sci (Lond) | NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling. | 2016 | Details |
| A48830 | 27339464 | Mol Imaging Biol | Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. | 2017 | Details |
| A48870 | 26019805 | Iran J Basic Med Sci | Modulation of IKKβ/NF-κB and TGF-β1/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice. | 2015 | Details |
| A48902 | 25086218 | Biochim Biophys Acta | Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. | 2014 | Details |
| A48954 | 23301878 | Hepatol Res | Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet. | 2013 | Details |
| A48989 | 22237790 | Minerva Anestesiol | Prolonged neuromuscular block associated to non-alcoholic steatohepatitis in morbidly obese patient: neostigmine versus sugammadex. | 2012 | Details |
| A49025 | 20979658 | Lipids Health Dis | Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. | 2010 | Details |
| A49027 | 20969493 | Scand J Gastroenterol | Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. | 2010 | Details |
| A49055 | 19840249 | Liver Int | Non-alcoholic steatohepatitis induces non-fibrosis-related portal hypertension associated with splanchnic vasodilation and signs of a hyperdynamic circulation in vitro and in vivo in a rat model. | 2009 | Details |
| A49064 | 19594730 | Basic Clin Pharmacol Toxicol | Progression of lipid peroxidation measured as thiobarbituric acid reactive substances, damage to DNA and histopathological changes in the liver of rats subjected to a methionine-choline-deficient diet. | 2009 | Details |
| A49101 | 17644211 | J Hepatol | Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A49144 | 16296871 | Drugs | Pathophysiological basis for antioxidant therapy in chronic liver disease. | 2005 | Details |
| A49171 | 15582125 | J Hepatol | Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. | 2004 | Details |
| A49179 | 15368443 | Hepatology | Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. | 2004 | Details |
| A49276 | 35804007 | Sci Rep | IκBζ regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice. | 2022 | Details |
| A49284 | 35800450 | Front Pharmacol | Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation. | 2022 | Details |
| A49294 | 35796622 | Hepatology | RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling. | 2022 | Details |
| A49326 | 35787975 | Cell Mol Gastroenterol Hepatol | Cell-specific deletion of NLRP3 inflammasome identifies myeloid cells as key drivers of liver inflammation and fibrosis in murine steatohepatitis. | 2022 | Details |
| A49331 | 35786482 | Sheng Wu Gong Cheng Xue Bao | [Lipid characteristics of fatty liver induced by high expression of Golgi protein 73]. | 2022 | Details |
| A49377 | 35769208 | Mediators Inflamm | MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice. | 2022 | Details |
| A49396 | 35765026 | J Transl Med | Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. | 2022 | Details |
| A49434 | 35749236 | J Nat Prod | Xyloketal B Reverses Nutritional Hepatic Steatosis, Steatohepatitis, and Liver Fibrosis through Activation of the PPARα/PGC1α Signaling Pathway. | 2022 | Details |
| A49455 | 35745142 | Nutrients | Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice. | 2022 | Details |
| A49463 | 35744053 | Medicina (Kaunas) | Deuterium-Reinforced Polyunsaturated Fatty Acids Prevent Diet-Induced Nonalcoholic Steatohepatitis by Reducing Oxidative Stress. | 2022 | Details |
| A49470 | 35743260 | Int J Mol Sci | MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis. | 2022 | Details |
| A49473 | 35743140 | Int J Mol Sci | Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis. | 2022 | Details |