Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A05245 | 33326461 | PLoS One | The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model. | 2020 | Details |
| A05249 | 33324348 | Front Endocrinol (Lausanne) | Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides. | 2020 | Details |
| A05254 | 33321470 | Nucl Med Biol | Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1. | 2020 | Details |
| A05262 | 33320268 | J Infect Dis | Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls. | 2021 | Details |
| A05263 | 33320193 | Endocrinology | The Importance of Keeping Time in the Liver. | 2021 | Details |
| A05266 | 33319459 | Liver Int | Metabolic-associated fatty liver disease (MAFLD) in coeliac disease. | 2020 | Details |
| A05267 | 33319051 | JGH Open | Use of simple scoring systems for a public health approach in the management of non-alcoholic fatty liver disease patients. | 2020 | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | 2020 | Details |
| A05270 | 33318479 | Cell Death Dis | Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner. | 2020 | Details |
| A05272 | 33317575 | Lipids Health Dis | A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. | 2020 | Details |
| A05278 | 33315911 | PLoS One | The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension. | 2020 | Details |
| A05287 | 33312420 | World J Hepatol | Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo. | 2020 | Details |
| A05288 | 33311949 | World J Gastroenterol | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome. | 2020 | Details |
| A05292 | 33310266 | Diabetes Metab Syndr | Performance of serum CD163 as a marker of fibrosis in patients with NAFLD. | 2020 | Details |
| A05299 | 33309037 | Am J Surg | The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests. | 2020 | Details |
| A05305 | 33307138 | J Hepatol | Refining the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease. | 2020 | Details |
| A05306 | 33307033 | Gastroenterology | The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis. | 2020 | Details |
| A05307 | 33307021 | Gastroenterology | AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review. | 2020 | Details |
| A05310 | 33306598 | J Chin Med Assoc | Interleukin-2 receptor alpha as a biomarker for nonalcoholic fatty liver disease diagnosis. | 2021 | Details |
| A05311 | 33306506 | Am J Gastroenterol | Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD. | 2021 | Details |
| A05312 | 33305889 | Pediatr Obes | The relationship between excessive dietary fructose consumption and paediatric fatty liver disease. | 2020 | Details |
| A05313 | 33305150 | Hepatol Commun | Elevated Glycated Hemoglobin Is Associated With Liver Fibrosis, as Assessed by Elastography, in a Population-Based Study of Mexican Americans. | 2020 | Details |
| A05315 | 33304627 | Curr Health Sci J | The Role of Elastography in Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05319 | 33303715 | Ann Lab Med | Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases. | 2021 | Details |
| A05320 | 33303638 | Diabetes Care | High Prevalence of Advanced Liver Fibrosis Assessed by Transient Elastography Among U.S. Adults With Type 2 Diabetes. | 2020 | Details |
| A05334 | 33299110 | Mod Pathol | A large-scale internal validation study of unsupervised virtual trichrome staining technologies on nonalcoholic steatohepatitis liver biopsies. | 2020 | Details |
| A05340 | 33296704 | Diabetes Metab | NAFLD, and cardiovascular and cardiac diseases: Factors influencing risk, prediction and treatment. | 2020 | Details |
| A05341 | 33296678 | Cell Metab | Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05342 | 33294831 | JHEP Rep | Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease. | 2020 | Details |
| A05343 | 33294458 | Biomed Res Int | APOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic Inflammation in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05349 | 33291177 | Z Gastroenterol | [Liver-specific diagnostic for non-alcoholic fatty liver disease (NAFLD) - time to replace liver biopsy?] | 2020 | Details |
| A05355 | 33284502 | Hepatology | Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. | 2021 | Details |
| A05356 | 33284184 | Am J Gastroenterol | Role of Noninvasive Tests in Clinical Gastroenterology Practices to Identify Patients With Nonalcoholic Steatohepatitis at High Risk of Adverse Outcomes: Expert Panel Recommendations. | 2021 | Details |
| A05358 | 33283415 | Liver Int | Fibrosis progression rate in a systematic review of placebo-treated nonalcoholic steatohepatitis. | 2020 | Details |
| A05364 | 33281770 | Front Microbiol | Novel Odoribacter splanchnicus Strain and Its Outer Membrane Vesicles Exert Immunoregulatory Effects in vitro. | 2020 | Details |
| A05367 | 33281161 | Intern Med | Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Cirrhosis Confirmed by Liver Histology after 14 Years. | 2020 | Details |
| A05376 | 33278029 | Pharmacotherapy | Emerging therapies for the treatment of nonalcoholic steatohepatitis: A systematic review. | 2021 | Details |
| A05381 | 33275980 | Metabolism | Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression. | 2020 | Details |
| A05383 | 33275637 | PLoS One | The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A05384 | 33275326 | Diabetes Obes Metab | Extended-release naltrexone/bupropion and liver health: Pooled, post hoc analysis from four randomized controlled trials. | 2021 | Details |
| A05392 | 33272889 | Clin Res Hepatol Gastroenterol | Vitamin E in paediatric non-alcoholic fatty liver disease: a meta-analysis. | 2020 | Details |
| A05399 | 33270924 | J Bone Miner Res | Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models. | 2020 | Details |
| A05403 | 33269420 | Hepatol Int | Association of arterial stiffness with the histological severity of nonalcoholic fatty liver disease. | 2020 | Details |
| A05405 | 33269229 | Quant Imaging Med Surg | Collagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model. | 2020 | Details |
| A05406 | 33269025 | J Med Biochem | Is endocan a novel potential biomarker of liver steatosis and fibrosis? | 2020 | Details |
| A05408 | 33268953 | World J Gastroenterol | Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease. | 2020 | Details |
| A05411 | 33268842 | Lab Invest | Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin. | 2020 | Details |
| A05413 | 33268509 | Sci Transl Med | Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. | 2020 | Details |
| A05414 | 33268508 | Sci Transl Med | Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. | 2020 | Details |
| A05415 | 33268450 | BMJ Open Diabetes Res Care | SGLT2 inhibitors in patients with type 2 diabetes with non-alcoholic fatty liver diseases: an umbrella review of systematic reviews. | 2020 | Details |
| A05417 | 33268036 | Clin Res Hepatol Gastroenterol | Modified AST to platelet ratio index improves APRI and better predicts advanced fibrosis and liver cirrhosis in patients with non-alcoholic fatty liver disease. | 2020 | Details |
| A05419 | 33266488 | Int J Mol Sci | Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P. | 2020 | Details |
| A05424 | 33261113 | Biomedicines | Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis. | 2020 | Details |
| A05425 | 33261044 | Int J Mol Sci | Soluble Endoglin as a Potential Biomarker of Nonalcoholic Steatohepatitis (NASH) Development, Participating in Aggravation of NASH-Related Changes in Mouse Liver. | 2020 | Details |
| A05431 | 33259835 | Metabolism | The effect of the magnitude of weight loss on non-alcoholic fatty liver disease: A systematic review and meta-analysis. | 2020 | Details |
| A05432 | 33259744 | Metab Syndr Relat Disord | Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity. | 2020 | Details |
| A05435 | 33257853 | Nat Biomed Eng | A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. | 2020 | Details |
| A05442 | 33255560 | Diagnostics (Basel) | Periostin Circulating Levels and Genetic Variants in Patients with Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05449 | 33253343 | Yonago Acta Med | Erratum for Ikeda et al., "Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease". | 2020 | Details |
| A05451 | 33252454 | Am J Gastroenterol | A Sequential Algorithm Combining ADAPT and Liver Stiffness Can Stage Metabolic-Associated Fatty Liver Disease in Hospital-Based and Primary Care Patients. | 2021 | Details |
| A05455 | 33250371 | Nutr Metab Cardiovasc Dis | Association between positivity of serum autoantibodies and liver disease severity in patients with biopsy-proven NAFLD. | 2020 | Details |
| A05456 | 33250172 | J Pediatr | The Prevalence of Nonalcoholic Fatty Liver Disease and Its Risk Factors in Children and Young Adults with Type 1 Diabetes Mellitus. | 2020 | Details |
| A05462 | 33248947 | Arch Biochem Biophys | The pivotal role of heme Oxygenase-1 in reversing the pathophysiology and systemic complications of NAFLD. | 2020 | Details |
| A05463 | 33248441 | J Clin Endocrinol Metab | Insulin Resistance Is Central to Long-Term Reversal of Histologic Nonalcoholic Steatohepatitis After Metabolic Surgery. | 2021 | Details |
| A05464 | 33248170 | J Hepatol | Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores. | 2020 | Details |
| A05474 | 33246008 | Metabolism | Moderate alcohol consumption is associated with advanced fibrosis in non-alcoholic fatty liver disease and shows a synergistic effect with type 2 diabetes mellitus. | 2020 | Details |
| A05479 | 33242590 | Biochim Biophys Acta Mol Basis Dis | Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy. | 2020 | Details |
| A05480 | 33241206 | JHEP Rep | Organoids to model liver disease. | 2020 | Details |
| A05486 | 33236445 | Hepatology | Myeloid-Cell-Specific IL-6 Signaling Promotes MicroRNA-223-Enriched Exosome Production to Attenuate NAFLD-Associated Fibrosis. | 2021 | Details |
| A05487 | 33236409 | Hepatology | Transient Versus Two-Dimensional Shear-Wave Elastography in a Multistep Strategy to Detect Advanced Fibrosis in NAFLD. | 2021 | Details |
| A05490 | 33235107 | Medicine (Baltimore) | Usefulness of controlled attenuation parameter and liver stiffness measurement for detecting increased arterial stiffness in asymptomatic populations in China. | 2020 | Details |
| A05493 | 33234364 | Phytomedicine | Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1. | 2020 | Details |
| A05494 | 33234342 | Clin Nutr | Mediterranean diet is inversely associated with steatosis and fibrosis and decreases ten-year diabetes and cardiovascular risk in NAFLD subjects: Results from the ATTICA prospective cohort study. | 2020 | Details |
| A05497 | 33232525 | J Gastroenterol Hepatol | FibroScan-aspartate aminotransferase score in an Asian cohort of non-alcoholic fatty liver disease and its utility in predicting histological resolution with bariatric surgery. | 2020 | Details |
| A05498 | 33230078 | J Pediatr Gastroenterol Nutr | Performance Characteristics, Intra- and Inter-operator Agreement of Transient Elastography in Pediatric Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A05499 | 33229553 | Proc Natl Acad Sci U S A | Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A05500 | 33228663 | J Transl Med | LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis. | 2020 | Details |
| A05502 | 33228201 | Diagnostics (Basel) | Chemerin Is a Valuable Biomarker in Patients with HCV Infection and Correlates with Liver Injury. | 2020 | Details |
| A05511 | 33222473 | Rev Esp Enferm Dig | Overall clinical and economic impact of non-alcoholic fatty liver disease. | 2021 | Details |
| A05514 | 33220492 | Mol Metab | Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans. | 2020 | Details |
| A05515 | 33220489 | Mol Metab | Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease. | 2020 | Details |
| A05521 | 33220028 | Med Ultrason | Ultrasound-Guided Attenuation Parameter (UGAP) for the quantification of liver steatosis using the Controlled Attenuation Parameter (CAP) as the reference method. | 2020 | Details |
| A05522 | 33219985 | Indian J Gastroenterol | Association between anti-acid therapies and advanced fibrosis in type 2 diabetics with biopsy-proven non-alcoholic fatty liver disease. | 2020 | Details |
| A05528 | 33218077 | Int J Mol Sci | PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. | 2020 | Details |
| A05529 | 33217835 | Medicine (Baltimore) | Effects of acupuncture for nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis. | 2020 | Details |
| A05533 | 33216772 | PLoS One | Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. | 2020 | Details |
| A05534 | 33216477 | Eur J Gastroenterol Hepatol | High rates of ineligibility for participation in trials of new therapies in non-alcoholic steatohepatitis: a systematic review. | 2020 | Details |
| A05541 | 33214165 | Gut | MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis. | 2020 | Details |
| A05547 | 33212187 | Biochim Biophys Acta Mol Basis Dis | Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis. | 2020 | Details |
| A05548 | 33212070 | Metabolism | MAFLD and risk of CKD. | 2020 | Details |
| A05551 | 33208891 | Cell Death Differ | RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. | 2020 | Details |
| A05553 | 33208241 | Med Hypotheses | Treatment of nonalcoholic fatty liver disease with an anti-osteoporotic medication: A hypothesis on drug repurposing. | 2020 | Details |
| A05556 | 33207561 | Int J Mol Sci | EZH2 as a Potential Target for NAFLD Therapy. | 2020 | Details |
| A05557 | 33207115 | Clin Mol Hepatol | Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective. | 2020 | Details |
| A05569 | 33203939 | Cell Mol Immunol | Immunopathobiology and therapeutic targets related to cytokines in liver diseases. | 2020 | Details |
| A05570 | 33203828 | Med Sci Monit | Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout. | 2020 | Details |
| A05575 | 33202851 | Antioxidants (Basel) | Antioxidant Lifestyle, Co-Morbidities and Quality of Life Empowerment Concerning Liver Fibrosis. | 2020 | Details |
| A05582 | 33200017 | World J Hepatol | PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease. | 2020 | Details |
| A05584 | 33199780 | Nat Commun | AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis. | 2020 | Details |
| A05586 | 33198849 | Br J Nutr | FNDC5 polymorphism influences the association between sarcopenia and liver fibrosis in adults with biopsy-proven non-alcoholic fatty liver disease. | 2020 | Details |